MDEP_STAA8
ID MDEP_STAA8 Reviewed; 157 AA.
AC Q2FW84;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Multidrug resistance efflux pump SepA;
DE AltName: Full=Antiseptic resistance protein SepA;
DE AltName: Full=Staphylococcal efflux pump A;
GN Name=sepA; OrderedLocusNames=SAOUHSC_02419;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- FUNCTION: Involved in multidrug efflux. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the multidrug resistance efflux pump SepA
CC family. {ECO:0000305}.
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DR EMBL; CP000253; ABD31444.1; -; Genomic_DNA.
DR RefSeq; WP_000636857.1; NZ_LS483365.1.
DR RefSeq; YP_500891.1; NC_007795.1.
DR AlphaFoldDB; Q2FW84; -.
DR STRING; 1280.SAXN108_2415; -.
DR EnsemblBacteria; ABD31444; ABD31444; SAOUHSC_02419.
DR GeneID; 3919630; -.
DR KEGG; sao:SAOUHSC_02419; -.
DR PATRIC; fig|93061.5.peg.2184; -.
DR eggNOG; ENOG5033YVE; Bacteria.
DR HOGENOM; CLU_151983_0_0_9; -.
DR OMA; ISYMVAT; -.
DR PRO; PR:Q2FW84; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR031396; SepA.
DR Pfam; PF17080; SepA; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..157
FT /note="Multidrug resistance efflux pump SepA"
FT /id="PRO_0000351491"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 157 AA; 18899 MW; 385E73CE8F18B019 CRC64;
MIVNYLKHKF YNLLTTMIVL FIFVLSGAIF LTFLGFGLYG LSRILIYFRL GDFTYNRSMY
DNLLYYGSYI IFGYFIIFAV EHLMDYFRKM LPENAYFRGA TFHLISYTVA TTLFYFIIHL
NYVYINIDFW VIMVIIGFLY VCKLQFYPES KNLNNRK