ID   MDEP_STAAE              Reviewed;         157 AA.
AC   A6QJ09;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Multidrug resistance efflux pump SepA;
DE   AltName: Full=Antiseptic resistance protein SepA;
DE   AltName: Full=Staphylococcal efflux pump A;
GN   Name=sepA; OrderedLocusNames=NWMN_2069;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
CC   -!- FUNCTION: Involved in multidrug efflux. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the multidrug resistance efflux pump SepA
CC       family. {ECO:0000305}.
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DR   EMBL; AP009351; BAF68341.1; -; Genomic_DNA.
DR   RefSeq; WP_000636857.1; NZ_CP023390.1.
DR   AlphaFoldDB; A6QJ09; -.
DR   EnsemblBacteria; BAF68341; BAF68341; NWMN_2069.
DR   KEGG; sae:NWMN_2069; -.
DR   HOGENOM; CLU_151983_0_0_9; -.
DR   OMA; ISYMVAT; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031396; SepA.
DR   Pfam; PF17080; SepA; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..157
FT                   /note="Multidrug resistance efflux pump SepA"
FT                   /id="PRO_0000351492"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   157 AA;  18899 MW;  385E73CE8F18B019 CRC64;
     MIVNYLKHKF YNLLTTMIVL FIFVLSGAIF LTFLGFGLYG LSRILIYFRL GDFTYNRSMY
     DNLLYYGSYI IFGYFIIFAV EHLMDYFRKM LPENAYFRGA TFHLISYTVA TTLFYFIIHL
     NYVYINIDFW VIMVIIGFLY VCKLQFYPES KNLNNRK