ID   MDEP_STAAM              Reviewed;         157 AA.
AC   Q7A2M6;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Multidrug resistance efflux pump SepA;
DE   AltName: Full=Antiseptic resistance protein SepA;
DE   AltName: Full=Staphylococcal efflux pump A;
GN   Name=sepA; OrderedLocusNames=SAV2167;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Involved in multidrug efflux. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the multidrug resistance efflux pump SepA
CC       family. {ECO:0000305}.
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DR   EMBL; BA000017; BAB58329.1; -; Genomic_DNA.
DR   RefSeq; WP_000636857.1; NC_002758.2.
DR   AlphaFoldDB; Q7A2M6; -.
DR   PaxDb; Q7A2M6; -.
DR   EnsemblBacteria; BAB58329; BAB58329; SAV2167.
DR   KEGG; sav:SAV2167; -.
DR   HOGENOM; CLU_151983_0_0_9; -.
DR   OMA; ISYMVAT; -.
DR   BioCyc; SAUR158878:SAV_RS11865-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031396; SepA.
DR   Pfam; PF17080; SepA; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..157
FT                   /note="Multidrug resistance efflux pump SepA"
FT                   /id="PRO_0000351488"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   157 AA;  18899 MW;  385E73CE8F18B019 CRC64;
     MIVNYLKHKF YNLLTTMIVL FIFVLSGAIF LTFLGFGLYG LSRILIYFRL GDFTYNRSMY
     DNLLYYGSYI IFGYFIIFAV EHLMDYFRKM LPENAYFRGA TFHLISYTVA TTLFYFIIHL
     NYVYINIDFW VIMVIIGFLY VCKLQFYPES KNLNNRK