ID   MDEP_STAAU              Reviewed;         157 AA.
AC   Q99S98;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Multidrug resistance efflux pump SepA;
DE   AltName: Full=Antiseptic resistance protein SepA;
DE   AltName: Full=Staphylococcal efflux pump A;
GN   Name=sepA;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION IN DRUG EFFLUX.
RC   STRAIN=RN2677;
RX   PubMed=12499635; DOI=10.1248/bpb.25.1533;
RA   Narui K., Noguchi N., Wakasugi K., Sasatsu M.;
RT   "Cloning and characterization of a novel chromosomal drug efflux gene in
RT   Staphylococcus aureus.";
RL   Biol. Pharm. Bull. 25:1533-1536(2002).
CC   -!- FUNCTION: Involved in multidrug efflux. Confers low level resistance to
CC       drugs such as acriflavine, benzalkonium chloride, chlorhexidine
CC       gluconate and ethidium bromide. {ECO:0000269|PubMed:12499635}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the multidrug resistance efflux pump SepA
CC       family. {ECO:0000305}.
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DR   EMBL; AB078343; BAB83937.1; -; Genomic_DNA.
DR   RefSeq; WP_000636857.1; NZ_WYDB01000011.1.
DR   AlphaFoldDB; Q99S98; -.
DR   OMA; ISYMVAT; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031396; SepA.
DR   Pfam; PF17080; SepA; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..157
FT                   /note="Multidrug resistance efflux pump SepA"
FT                   /id="PRO_0000351482"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   157 AA;  18899 MW;  385E73CE8F18B019 CRC64;
     MIVNYLKHKF YNLLTTMIVL FIFVLSGAIF LTFLGFGLYG LSRILIYFRL GDFTYNRSMY
     DNLLYYGSYI IFGYFIIFAV EHLMDYFRKM LPENAYFRGA TFHLISYTVA TTLFYFIIHL
     NYVYINIDFW VIMVIIGFLY VCKLQFYPES KNLNNRK