ID   MDEP_STAES              Reviewed;         155 AA.
AC   Q8CRK7;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 2.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Multidrug resistance efflux pump SepA;
DE   AltName: Full=Antiseptic resistance protein SepA;
DE   AltName: Full=Staphylococcal efflux pump A;
GN   Name=sepA; OrderedLocusNames=SE_1758;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Involved in multidrug efflux. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the multidrug resistance efflux pump SepA
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO05399.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE015929; AAO05399.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_765313.1; NC_004461.1.
DR   RefSeq; WP_001829729.1; NC_004461.1.
DR   AlphaFoldDB; Q8CRK7; -.
DR   STRING; 176280.SE_1758; -.
DR   EnsemblBacteria; AAO05399; AAO05399; SE_1758.
DR   GeneID; 50018137; -.
DR   KEGG; sep:SE_1758; -.
DR   PATRIC; fig|176280.10.peg.1716; -.
DR   eggNOG; ENOG5033YVE; Bacteria.
DR   HOGENOM; CLU_151983_0_0_9; -.
DR   OMA; ISYMVAT; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031396; SepA.
DR   Pfam; PF17080; SepA; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..155
FT                   /note="Multidrug resistance efflux pump SepA"
FT                   /id="PRO_0000351495"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   155 AA;  18447 MW;  9C87245FC3FCDBB3 CRC64;
     MKFLKNKSYH LLVTLIVLTI FVISGAIFLT FLGFGLYGLS RILIYLHLGD FSYNKGFYDN
     LIYYGSYIVL GYFTLFSIEH LMDYFKKNLP KNPYFQGINF HLISYIVTTI MFYFIVHIHY
     VHVNIHFWVI MIIIGFLFVC KEVFYPESKN LNNKK