ID   MDEP_STAHJ              Reviewed;         155 AA.
AC   Q4L843;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Multidrug resistance efflux pump SepA;
DE   AltName: Full=Antiseptic resistance protein SepA;
DE   AltName: Full=Staphylococcal efflux pump A;
GN   Name=sepA; OrderedLocusNames=SH0873;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Involved in multidrug efflux. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the multidrug resistance efflux pump SepA
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP006716; BAE04182.1; -; Genomic_DNA.
DR   RefSeq; WP_011275185.1; NC_007168.1.
DR   AlphaFoldDB; Q4L843; -.
DR   STRING; 279808.SH0873; -.
DR   EnsemblBacteria; BAE04182; BAE04182; SH0873.
DR   GeneID; 58062950; -.
DR   KEGG; sha:SH0873; -.
DR   eggNOG; ENOG5033YVE; Bacteria.
DR   HOGENOM; CLU_151983_0_0_9; -.
DR   OMA; ISYMVAT; -.
DR   OrthoDB; 1698573at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031396; SepA.
DR   Pfam; PF17080; SepA; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..155
FT                   /note="Multidrug resistance efflux pump SepA"
FT                   /id="PRO_0000351497"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   155 AA;  18523 MW;  BF8095452B53964D CRC64;
     MKFFKNNYKN ILSTLLVLTI FIISGAIFLM FLGFGLFGLS RILIFFKLGY FTYNKNLVDN
     LVYYGSYIVF GYFILFAIEH LMDYFRKQLP NNPYFNGSLY QLISYVVTTI LFYFIIHIHY
     VYIEIDFWVI SVIIGLLYIF KIIFYPDSEN LNNKK