MDFI_HUMAN
ID MDFI_HUMAN Reviewed; 246 AA.
AC Q99750;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=MyoD family inhibitor;
DE AltName: Full=Myogenic repressor I-mf;
GN Name=MDFI;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetal brain;
RX PubMed=9250874; DOI=10.1007/s003359900517;
RA Kraut N.;
RT "The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and mouse
RT chromosome 17.";
RL Mamm. Genome 8:618-619(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH CCNT2.
RX PubMed=17289077; DOI=10.1016/j.jmb.2007.01.020;
RA Wang Q., Young T.M., Mathews M.B., Pe'ery T.;
RT "Developmental regulators containing the I-mfa domain interact with T
RT cyclins and Tat and modulate transcription.";
RL J. Mol. Biol. 367:630-646(2007).
CC -!- FUNCTION: Inhibits the transactivation activity of the Myod family of
CC myogenic factors and represses myogenesis. Acts by associating with
CC Myod family members and retaining them in the cytoplasm by masking
CC their nuclear localization signals. Can also interfere with the DNA-
CC binding activity of Myod family members. Plays an important role in
CC trophoblast and chondrogenic differentiation. Regulates the
CC transcriptional activity of TCF7L1/TCF3 by interacting directly with
CC TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin
CC complex, resulting in an increase in the level of free beta-catenin.
CC Affects axin regulation of the WNT and JNK signaling pathways (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: The C-terminus interacts with AXIN1 and LEF1 (By similarity).
CC Interacts with CCNT2 (PubMed:17289077). {ECO:0000250|UniProtKB:P70331,
CC ECO:0000269|PubMed:17289077}.
CC -!- INTERACTION:
CC Q99750; Q16613: AANAT; NbExp=6; IntAct=EBI-724076, EBI-7451846;
CC Q99750; A0A0S2Z645: ABCF3; NbExp=3; IntAct=EBI-724076, EBI-16432404;
CC Q99750; Q8NFV4-4: ABHD11; NbExp=3; IntAct=EBI-724076, EBI-12318443;
CC Q99750; P82987: ADAMTSL3; NbExp=6; IntAct=EBI-724076, EBI-10221726;
CC Q99750; P18825: ADRA2C; NbExp=3; IntAct=EBI-724076, EBI-12015266;
CC Q99750; Q6ZN18-2: AEBP2; NbExp=3; IntAct=EBI-724076, EBI-10255023;
CC Q99750; P21549: AGXT; NbExp=5; IntAct=EBI-724076, EBI-727098;
CC Q99750; Q02040-3: AKAP17A; NbExp=3; IntAct=EBI-724076, EBI-10222656;
CC Q99750; P29972: AQP1; NbExp=7; IntAct=EBI-724076, EBI-745213;
CC Q99750; P55064: AQP5; NbExp=3; IntAct=EBI-724076, EBI-746103;
CC Q99750; A7KAX9: ARHGAP32; NbExp=3; IntAct=EBI-724076, EBI-308663;
CC Q99750; Q03989: ARID5A; NbExp=5; IntAct=EBI-724076, EBI-948603;
CC Q99750; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-724076, EBI-742909;
CC Q99750; P30049: ATP5F1D; NbExp=3; IntAct=EBI-724076, EBI-1049505;
CC Q99750; Q5T686: AVPI1; NbExp=7; IntAct=EBI-724076, EBI-8640233;
CC Q99750; A0A0S2Z4M1: AXIN1; NbExp=3; IntAct=EBI-724076, EBI-16429430;
CC Q99750; O15169: AXIN1; NbExp=3; IntAct=EBI-724076, EBI-710484;
CC Q99750; O95817: BAG3; NbExp=3; IntAct=EBI-724076, EBI-747185;
CC Q99750; Q8TBE0: BAHD1; NbExp=7; IntAct=EBI-724076, EBI-742750;
CC Q99750; A0A0S2Z5G4: BANP; NbExp=3; IntAct=EBI-724076, EBI-16429704;
CC Q99750; B4DE54: BANP; NbExp=3; IntAct=EBI-724076, EBI-16429313;
CC Q99750; Q8N9N5-2: BANP; NbExp=6; IntAct=EBI-724076, EBI-11524452;
CC Q99750; Q8N9N5-7: BANP; NbExp=3; IntAct=EBI-724076, EBI-16429296;
CC Q99750; Q9BXC9: BBS2; NbExp=7; IntAct=EBI-724076, EBI-748297;
CC Q99750; P50895: BCAM; NbExp=3; IntAct=EBI-724076, EBI-10212133;
CC Q99750; A8KA13: BCL6B; NbExp=3; IntAct=EBI-724076, EBI-10174813;
CC Q99750; Q9HBH7: BEX1; NbExp=6; IntAct=EBI-724076, EBI-7162175;
CC Q99750; Q9BXY8: BEX2; NbExp=4; IntAct=EBI-724076, EBI-745073;
CC Q99750; Q00994: BEX3; NbExp=3; IntAct=EBI-724076, EBI-741753;
CC Q99750; Q5T681: C10orf62; NbExp=7; IntAct=EBI-724076, EBI-744052;
CC Q99750; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-724076, EBI-747505;
CC Q99750; Q6P5X5: C22orf39; NbExp=3; IntAct=EBI-724076, EBI-7317823;
CC Q99750; Q96LM5: C4orf45; NbExp=3; IntAct=EBI-724076, EBI-12020542;
CC Q99750; Q9H7E9: C8orf33; NbExp=5; IntAct=EBI-724076, EBI-715389;
CC Q99750; Q96LL4: C8orf48; NbExp=6; IntAct=EBI-724076, EBI-751596;
CC Q99750; Q8NEC5: CATSPER1; NbExp=4; IntAct=EBI-724076, EBI-744545;
CC Q99750; O43439: CBFA2T2; NbExp=4; IntAct=EBI-724076, EBI-748628;
CC Q99750; Q8N7E2: CBLL2; NbExp=3; IntAct=EBI-724076, EBI-12196065;
CC Q99750; Q14781: CBX2; NbExp=3; IntAct=EBI-724076, EBI-745934;
CC Q99750; Q14781-2: CBX2; NbExp=3; IntAct=EBI-724076, EBI-11974585;
CC Q99750; Q9HC52: CBX8; NbExp=3; IntAct=EBI-724076, EBI-712912;
CC Q99750; Q5T0F9: CC2D1B; NbExp=3; IntAct=EBI-724076, EBI-10245204;
CC Q99750; Q5T0F9-3: CC2D1B; NbExp=3; IntAct=EBI-724076, EBI-13176876;
CC Q99750; Q8IYX3: CCDC116; NbExp=7; IntAct=EBI-724076, EBI-744311;
CC Q99750; Q8N715: CCDC185; NbExp=4; IntAct=EBI-724076, EBI-740814;
CC Q99750; Q9NVL8: CCDC198; NbExp=3; IntAct=EBI-724076, EBI-10238351;
CC Q99750; Q96S94-5: CCNL2; NbExp=3; IntAct=EBI-724076, EBI-12024864;
CC Q99750; Q86Y33-5: CDC20B; NbExp=3; IntAct=EBI-724076, EBI-11983537;
CC Q99750; Q16543: CDC37; NbExp=3; IntAct=EBI-724076, EBI-295634;
CC Q99750; Q96GN5: CDCA7L; NbExp=6; IntAct=EBI-724076, EBI-5278764;
CC Q99750; Q8IVW4: CDKL3; NbExp=3; IntAct=EBI-724076, EBI-3919850;
CC Q99750; Q8IYX8: CEP57L1; NbExp=6; IntAct=EBI-724076, EBI-1104570;
CC Q99750; O43745: CHP2; NbExp=3; IntAct=EBI-724076, EBI-8525536;
CC Q99750; P07510-2: CHRNG; NbExp=6; IntAct=EBI-724076, EBI-11979451;
CC Q99750; Q8NE01: CNNM3; NbExp=6; IntAct=EBI-724076, EBI-741032;
CC Q99750; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-724076, EBI-739773;
CC Q99750; Q02930-3: CREB5; NbExp=8; IntAct=EBI-724076, EBI-10192698;
CC Q99750; P06850: CRH; NbExp=3; IntAct=EBI-724076, EBI-3870390;
CC Q99750; Q9Y6M4-3: CSNK1G3; NbExp=3; IntAct=EBI-724076, EBI-11045281;
CC Q99750; Q99895: CTRC; NbExp=3; IntAct=EBI-724076, EBI-10295404;
CC Q99750; Q6DCB0: DAAM2; NbExp=3; IntAct=EBI-724076, EBI-10249414;
CC Q99750; Q8NFT6-2: DBF4B; NbExp=3; IntAct=EBI-724076, EBI-12205861;
CC Q99750; Q58WW2: DCAF6; NbExp=3; IntAct=EBI-724076, EBI-2559044;
CC Q99750; Q5TAQ9: DCAF8; NbExp=6; IntAct=EBI-724076, EBI-740686;
CC Q99750; Q8TF63: DCANP1; NbExp=7; IntAct=EBI-724076, EBI-10275670;
CC Q99750; Q96LJ7: DHRS1; NbExp=4; IntAct=EBI-724076, EBI-746300;
CC Q99750; O94907: DKK1; NbExp=4; IntAct=EBI-724076, EBI-742864;
CC Q99750; Q9NQL9: DMRT3; NbExp=6; IntAct=EBI-724076, EBI-9679045;
CC Q99750; P59910: DNAJB13; NbExp=3; IntAct=EBI-724076, EBI-11514233;
CC Q99750; Q9Y6K1: DNMT3A; NbExp=3; IntAct=EBI-724076, EBI-923653;
CC Q99750; Q92608: DOCK2; NbExp=8; IntAct=EBI-724076, EBI-448771;
CC Q99750; Q7L591-3: DOK3; NbExp=3; IntAct=EBI-724076, EBI-10694655;
CC Q99750; Q5JR98: DYNLT4; NbExp=3; IntAct=EBI-724076, EBI-4311709;
CC Q99750; O95967: EFEMP2; NbExp=3; IntAct=EBI-724076, EBI-743414;
CC Q99750; Q14240-2: EIF4A2; NbExp=3; IntAct=EBI-724076, EBI-10232522;
CC Q99750; Q14241: ELOA; NbExp=6; IntAct=EBI-724076, EBI-742350;
CC Q99750; Q9H0I2: ENKD1; NbExp=8; IntAct=EBI-724076, EBI-744099;
CC Q99750; Q92731-3: ESR2; NbExp=3; IntAct=EBI-724076, EBI-12259414;
CC Q99750; Q0VG06-3: FAAP100; NbExp=3; IntAct=EBI-724076, EBI-10226932;
CC Q99750; Q8N9I5: FADS6; NbExp=3; IntAct=EBI-724076, EBI-3943864;
CC Q99750; Q5T036: FAM120AOS; NbExp=3; IntAct=EBI-724076, EBI-12420808;
CC Q99750; Q9H5Z6: FAM124B; NbExp=4; IntAct=EBI-724076, EBI-741626;
CC Q99750; Q3B820: FAM161A; NbExp=6; IntAct=EBI-724076, EBI-719941;
CC Q99750; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-724076, EBI-7225287;
CC Q99750; Q7L5A3: FAM214B; NbExp=4; IntAct=EBI-724076, EBI-745689;
CC Q99750; Q08E93: FAM27E3; NbExp=3; IntAct=EBI-724076, EBI-2602739;
CC Q99750; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-724076, EBI-6658203;
CC Q99750; O95363: FARS2; NbExp=3; IntAct=EBI-724076, EBI-2513774;
CC Q99750; Q96D16: FBXL18; NbExp=5; IntAct=EBI-724076, EBI-744419;
CC Q99750; Q9NWN3: FBXO34; NbExp=3; IntAct=EBI-724076, EBI-719816;
CC Q99750; A0PJY2: FEZF1; NbExp=3; IntAct=EBI-724076, EBI-11988727;
CC Q99750; Q9BVV2: FNDC11; NbExp=3; IntAct=EBI-724076, EBI-744935;
CC Q99750; Q12950: FOXD4; NbExp=3; IntAct=EBI-724076, EBI-11317801;
CC Q99750; Q9NU39: FOXD4L1; NbExp=3; IntAct=EBI-724076, EBI-11320806;
CC Q99750; Q6VB84: FOXD4L3; NbExp=3; IntAct=EBI-724076, EBI-11961494;
CC Q99750; Q3SYB3: FOXD4L6; NbExp=6; IntAct=EBI-724076, EBI-6425864;
CC Q99750; O14764: GABRD; NbExp=3; IntAct=EBI-724076, EBI-744352;
CC Q99750; P15976-2: GATA1; NbExp=5; IntAct=EBI-724076, EBI-9090198;
CC Q99750; P23769: GATA2; NbExp=4; IntAct=EBI-724076, EBI-2806671;
CC Q99750; Q99988: GDF15; NbExp=5; IntAct=EBI-724076, EBI-2116863;
CC Q99750; P04899: GNAI2; NbExp=5; IntAct=EBI-724076, EBI-353997;
CC Q99750; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-724076, EBI-11975289;
CC Q99750; P63218: GNG5; NbExp=3; IntAct=EBI-724076, EBI-10220734;
CC Q99750; O95872: GPANK1; NbExp=3; IntAct=EBI-724076, EBI-751540;
CC Q99750; Q9NWQ4: GPATCH2L; NbExp=3; IntAct=EBI-724076, EBI-5666657;
CC Q99750; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-724076, EBI-11959863;
CC Q99750; O60565: GREM1; NbExp=3; IntAct=EBI-724076, EBI-944395;
CC Q99750; Q9Y5Q8: GTF3C5; NbExp=3; IntAct=EBI-724076, EBI-1045409;
CC Q99750; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-724076, EBI-11956675;
CC Q99750; Q8TF76: HASPIN; NbExp=3; IntAct=EBI-724076, EBI-1237328;
CC Q99750; A0A024R5S0: hCG_2003792; NbExp=3; IntAct=EBI-724076, EBI-10188461;
CC Q99750; B4DNA4: hCG_20425; NbExp=3; IntAct=EBI-724076, EBI-7399002;
CC Q99750; Q9NQ87: HEYL; NbExp=7; IntAct=EBI-724076, EBI-751092;
CC Q99750; Q03014: HHEX; NbExp=3; IntAct=EBI-724076, EBI-747421;
CC Q99750; Q9XRX5-2: HHLA3; NbExp=3; IntAct=EBI-724076, EBI-12051311;
CC Q99750; Q8WVV9: HNRNPLL; NbExp=4; IntAct=EBI-724076, EBI-535849;
CC Q99750; P49639: HOXA1; NbExp=7; IntAct=EBI-724076, EBI-740785;
CC Q99750; P17482: HOXB9; NbExp=6; IntAct=EBI-724076, EBI-745290;
CC Q99750; P37235: HPCAL1; NbExp=3; IntAct=EBI-724076, EBI-749311;
CC Q99750; P28222: HTR1B; NbExp=7; IntAct=EBI-724076, EBI-1056863;
CC Q99750; Q12894-2: IFRD2; NbExp=3; IntAct=EBI-724076, EBI-14102882;
CC Q99750; Q8NA54: IQUB; NbExp=3; IntAct=EBI-724076, EBI-10220600;
CC Q99750; P16144-2: ITGB4; NbExp=3; IntAct=EBI-724076, EBI-11051601;
CC Q99750; Q15040: JOSD1; NbExp=3; IntAct=EBI-724076, EBI-2510602;
CC Q99750; Q92993: KAT5; NbExp=3; IntAct=EBI-724076, EBI-399080;
CC Q99750; Q96MP8-2: KCTD7; NbExp=3; IntAct=EBI-724076, EBI-11954971;
CC Q99750; A0A384DVV8: KIAA0040; NbExp=6; IntAct=EBI-724076, EBI-20764875;
CC Q99750; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-724076, EBI-6426443;
CC Q99750; P52292: KPNA2; NbExp=3; IntAct=EBI-724076, EBI-349938;
CC Q99750; Q7Z794: KRT77; NbExp=3; IntAct=EBI-724076, EBI-3045529;
CC Q99750; A0A0S2Z3Z3: LAMB3; NbExp=3; IntAct=EBI-724076, EBI-16435132;
CC Q99750; Q14847: LASP1; NbExp=3; IntAct=EBI-724076, EBI-742828;
CC Q99750; Q14847-2: LASP1; NbExp=3; IntAct=EBI-724076, EBI-9088686;
CC Q99750; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-724076, EBI-11962058;
CC Q99750; Q5T7P3: LCE1B; NbExp=4; IntAct=EBI-724076, EBI-10245913;
CC Q99750; Q5T752: LCE1D; NbExp=3; IntAct=EBI-724076, EBI-11741311;
CC Q99750; Q5T754: LCE1F; NbExp=3; IntAct=EBI-724076, EBI-11958008;
CC Q99750; O14633: LCE2B; NbExp=3; IntAct=EBI-724076, EBI-11478468;
CC Q99750; Q5TA76: LCE3A; NbExp=5; IntAct=EBI-724076, EBI-9394625;
CC Q99750; Q5T5A8: LCE3C; NbExp=5; IntAct=EBI-724076, EBI-10245291;
CC Q99750; Q9BYE3: LCE3D; NbExp=4; IntAct=EBI-724076, EBI-6658837;
CC Q99750; Q5T5B0: LCE3E; NbExp=8; IntAct=EBI-724076, EBI-10245456;
CC Q99750; Q5TA78: LCE4A; NbExp=6; IntAct=EBI-724076, EBI-10246358;
CC Q99750; Q7Z4I7-5: LIMS2; NbExp=3; IntAct=EBI-724076, EBI-10257651;
CC Q99750; O14910: LIN7A; NbExp=3; IntAct=EBI-724076, EBI-2513988;
CC Q99750; O75427: LRCH4; NbExp=3; IntAct=EBI-724076, EBI-718707;
CC Q99750; Q8TD91-2: MAGEC3; NbExp=3; IntAct=EBI-724076, EBI-10694180;
CC Q99750; Q9Y5V3: MAGED1; NbExp=6; IntAct=EBI-724076, EBI-716006;
CC Q99750; Q9HAY2: MAGEF1; NbExp=4; IntAct=EBI-724076, EBI-5525855;
CC Q99750; P28482: MAPK1; NbExp=3; IntAct=EBI-724076, EBI-959949;
CC Q99750; O60336: MAPKBP1; NbExp=6; IntAct=EBI-724076, EBI-947402;
CC Q99750; Q8NHZ7: MBD3L2; NbExp=3; IntAct=EBI-724076, EBI-11989378;
CC Q99750; Q99750: MDFI; NbExp=4; IntAct=EBI-724076, EBI-724076;
CC Q99750; Q9H7H0: METTL17; NbExp=5; IntAct=EBI-724076, EBI-749353;
CC Q99750; Q9H7H0-2: METTL17; NbExp=6; IntAct=EBI-724076, EBI-11098807;
CC Q99750; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-724076, EBI-14086479;
CC Q99750; P50539-3: MXI1; NbExp=3; IntAct=EBI-724076, EBI-10211940;
CC Q99750; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-724076, EBI-2858213;
CC Q99750; Q92692: NECTIN2; NbExp=4; IntAct=EBI-724076, EBI-718419;
CC Q99750; Q92692-2: NECTIN2; NbExp=3; IntAct=EBI-724076, EBI-6979889;
CC Q99750; Q8WWR8: NEU4; NbExp=4; IntAct=EBI-724076, EBI-746964;
CC Q99750; Q86XR2: NIBAN3; NbExp=3; IntAct=EBI-724076, EBI-2796690;
CC Q99750; Q969G9: NKD1; NbExp=3; IntAct=EBI-724076, EBI-1538217;
CC Q99750; Q9NQX5: NPDC1; NbExp=8; IntAct=EBI-724076, EBI-748927;
CC Q99750; Q8NDH3-5: NPEPL1; NbExp=3; IntAct=EBI-724076, EBI-12329915;
CC Q99750; F1D8P7: NR1H2; NbExp=6; IntAct=EBI-724076, EBI-10177172;
CC Q99750; P55055: NR1H2; NbExp=3; IntAct=EBI-724076, EBI-745354;
CC Q99750; Q13133: NR1H3; NbExp=3; IntAct=EBI-724076, EBI-781356;
CC Q99750; Q13133-2: NR1H3; NbExp=3; IntAct=EBI-724076, EBI-12699353;
CC Q99750; Q13133-3: NR1H3; NbExp=3; IntAct=EBI-724076, EBI-11952806;
CC Q99750; Q96L73-2: NSD1; NbExp=3; IntAct=EBI-724076, EBI-11110981;
CC Q99750; Q9Y5Y2: NUBP2; NbExp=3; IntAct=EBI-724076, EBI-1048886;
CC Q99750; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-724076, EBI-1210753;
CC Q99750; Q17RF5: ODAPH; NbExp=6; IntAct=EBI-724076, EBI-10239029;
CC Q99750; Q14990: ODF1; NbExp=3; IntAct=EBI-724076, EBI-10234557;
CC Q99750; A8MYP8: ODF3B; NbExp=3; IntAct=EBI-724076, EBI-12010090;
CC Q99750; Q7RTU3: OLIG3; NbExp=6; IntAct=EBI-724076, EBI-10225049;
CC Q99750; P32242: OTX1; NbExp=9; IntAct=EBI-724076, EBI-740446;
CC Q99750; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-724076, EBI-11022007;
CC Q99750; Q96AQ6: PBXIP1; NbExp=4; IntAct=EBI-724076, EBI-740845;
CC Q99750; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-724076, EBI-11956269;
CC Q99750; P04085-2: PDGFA; NbExp=3; IntAct=EBI-724076, EBI-11995148;
CC Q99750; Q14554: PDIA5; NbExp=3; IntAct=EBI-724076, EBI-953879;
CC Q99750; Q29RF7-3: PDS5A; NbExp=3; IntAct=EBI-724076, EBI-12067280;
CC Q99750; Q9HAT8: PELI2; NbExp=3; IntAct=EBI-724076, EBI-448407;
CC Q99750; O43189: PHF1; NbExp=3; IntAct=EBI-724076, EBI-530034;
CC Q99750; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-724076, EBI-14084211;
CC Q99750; Q8WV24: PHLDA1; NbExp=3; IntAct=EBI-724076, EBI-738731;
CC Q99750; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-724076, EBI-14066006;
CC Q99750; Q7Z2X4: PID1; NbExp=3; IntAct=EBI-724076, EBI-10256685;
CC Q99750; Q9HB75: PIDD1; NbExp=3; IntAct=EBI-724076, EBI-520427;
CC Q99750; Q8WWB5: PIH1D2; NbExp=6; IntAct=EBI-724076, EBI-10232538;
CC Q99750; Q13526: PIN1; NbExp=7; IntAct=EBI-724076, EBI-714158;
CC Q99750; P78337: PITX1; NbExp=3; IntAct=EBI-724076, EBI-748265;
CC Q99750; Q13563: PKD2; NbExp=3; IntAct=EBI-724076, EBI-7813714;
CC Q99750; Q58EX7: PLEKHG4; NbExp=3; IntAct=EBI-724076, EBI-949255;
CC Q99750; Q9UGP5-2: POLL; NbExp=3; IntAct=EBI-724076, EBI-10320765;
CC Q99750; O43741: PRKAB2; NbExp=12; IntAct=EBI-724076, EBI-1053424;
CC Q99750; Q99633: PRPF18; NbExp=3; IntAct=EBI-724076, EBI-2798416;
CC Q99750; Q8WWY3: PRPF31; NbExp=5; IntAct=EBI-724076, EBI-1567797;
CC Q99750; Q9NV39: PRR34; NbExp=3; IntAct=EBI-724076, EBI-11959565;
CC Q99750; Q13308: PTK7; NbExp=3; IntAct=EBI-724076, EBI-2803245;
CC Q99750; Q8WUK0: PTPMT1; NbExp=7; IntAct=EBI-724076, EBI-7199479;
CC Q99750; Q3YEC7: RABL6; NbExp=2; IntAct=EBI-724076, EBI-742029;
CC Q99750; P63000: RAC1; NbExp=3; IntAct=EBI-724076, EBI-413628;
CC Q99750; Q9Y272: RASD1; NbExp=5; IntAct=EBI-724076, EBI-740818;
CC Q99750; Q06141: REG3A; NbExp=3; IntAct=EBI-724076, EBI-10223932;
CC Q99750; Q96EN9: REX1BD; NbExp=6; IntAct=EBI-724076, EBI-745810;
CC Q99750; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-724076, EBI-372094;
CC Q99750; Q13671: RIN1; NbExp=3; IntAct=EBI-724076, EBI-366017;
CC Q99750; Q0D2K3: RIPPLY1; NbExp=6; IntAct=EBI-724076, EBI-10226430;
CC Q99750; A0A0S2Z4G9: RNF6; NbExp=3; IntAct=EBI-724076, EBI-16428950;
CC Q99750; Q14D33: RTP5; NbExp=6; IntAct=EBI-724076, EBI-10217913;
CC Q99750; Q86UD0: SAPCD2; NbExp=3; IntAct=EBI-724076, EBI-2561646;
CC Q99750; Q969E2: SCAMP4; NbExp=3; IntAct=EBI-724076, EBI-4403649;
CC Q99750; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-724076, EBI-748391;
CC Q99750; Q8WWX9: SELENOM; NbExp=3; IntAct=EBI-724076, EBI-10277687;
CC Q99750; Q13214-2: SEMA3B; NbExp=3; IntAct=EBI-724076, EBI-11017428;
CC Q99750; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-724076, EBI-10313866;
CC Q99750; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-724076, EBI-11955083;
CC Q99750; P34896: SHMT1; NbExp=3; IntAct=EBI-724076, EBI-715117;
CC Q99750; Q15475: SIX1; NbExp=2; IntAct=EBI-724076, EBI-743675;
CC Q99750; Q86YT5: SLC13A5; NbExp=3; IntAct=EBI-724076, EBI-12002412;
CC Q99750; Q8IY34: SLC15A3; NbExp=3; IntAct=EBI-724076, EBI-12179023;
CC Q99750; Q9UBX3: SLC25A10; NbExp=7; IntAct=EBI-724076, EBI-750394;
CC Q99750; Q9UBX3-2: SLC25A10; NbExp=3; IntAct=EBI-724076, EBI-12056597;
CC Q99750; Q8NB12: SMYD1; NbExp=3; IntAct=EBI-724076, EBI-8463848;
CC Q99750; Q96RF0: SNX18; NbExp=3; IntAct=EBI-724076, EBI-298169;
CC Q99750; O14512: SOCS7; NbExp=3; IntAct=EBI-724076, EBI-1539606;
CC Q99750; Q86W54-2: SPATA24; NbExp=3; IntAct=EBI-724076, EBI-12041693;
CC Q99750; Q6RVD6: SPATA8; NbExp=6; IntAct=EBI-724076, EBI-8635958;
CC Q99750; Q9UQ90: SPG7; NbExp=7; IntAct=EBI-724076, EBI-717201;
CC Q99750; Q9HCB6: SPON1; NbExp=3; IntAct=EBI-724076, EBI-2431846;
CC Q99750; Q7Z698: SPRED2; NbExp=3; IntAct=EBI-724076, EBI-7082156;
CC Q99750; O43609: SPRY1; NbExp=7; IntAct=EBI-724076, EBI-3866665;
CC Q99750; O43597: SPRY2; NbExp=3; IntAct=EBI-724076, EBI-742487;
CC Q99750; P51687: SUOX; NbExp=3; IntAct=EBI-724076, EBI-3921347;
CC Q99750; Q9BSH4: TACO1; NbExp=3; IntAct=EBI-724076, EBI-747797;
CC Q99750; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-724076, EBI-745958;
CC Q99750; Q6DHY5: TBC1D3G; NbExp=3; IntAct=EBI-724076, EBI-13092532;
CC Q99750; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-724076, EBI-11955057;
CC Q99750; A0A0S2Z4E5: TEAD4; NbExp=3; IntAct=EBI-724076, EBI-16432288;
CC Q99750; A0A0S2Z4F2: TEAD4; NbExp=3; IntAct=EBI-724076, EBI-16429215;
CC Q99750; Q7L2K0: TEDC2; NbExp=3; IntAct=EBI-724076, EBI-8465456;
CC Q99750; Q15583: TGIF1; NbExp=4; IntAct=EBI-724076, EBI-714215;
CC Q99750; P07101-3: TH; NbExp=3; IntAct=EBI-724076, EBI-12001016;
CC Q99750; Q9P2T0: THEG; NbExp=3; IntAct=EBI-724076, EBI-751020;
CC Q99750; Q08117-2: TLE5; NbExp=3; IntAct=EBI-724076, EBI-11741437;
CC Q99750; P19237: TNNI1; NbExp=3; IntAct=EBI-724076, EBI-746692;
CC Q99750; Q05952: TNP2; NbExp=4; IntAct=EBI-724076, EBI-12039775;
CC Q99750; Q4VB56: TNP2; NbExp=3; IntAct=EBI-724076, EBI-10241829;
CC Q99750; O14656: TOR1A; NbExp=3; IntAct=EBI-724076, EBI-524257;
CC Q99750; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-724076, EBI-492476;
CC Q99750; Q9Y260: TRPV6; NbExp=4; IntAct=EBI-724076, EBI-750052;
CC Q99750; P43897: TSFM; NbExp=3; IntAct=EBI-724076, EBI-1049298;
CC Q99750; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-724076, EBI-10241197;
CC Q99750; O14817: TSPAN4; NbExp=3; IntAct=EBI-724076, EBI-8652667;
CC Q99750; Q6FI91: TSPYL; NbExp=3; IntAct=EBI-724076, EBI-723389;
CC Q99750; Q8N831: TSPYL6; NbExp=3; IntAct=EBI-724076, EBI-12023322;
CC Q99750; Q5W5X9: TTC23; NbExp=3; IntAct=EBI-724076, EBI-6447954;
CC Q99750; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-724076, EBI-9090990;
CC Q99750; Q6ZVT0: TTLL10; NbExp=3; IntAct=EBI-724076, EBI-7844656;
CC Q99750; Q6ZVT0-3: TTLL10; NbExp=3; IntAct=EBI-724076, EBI-11979997;
CC Q99750; O75896: TUSC2; NbExp=7; IntAct=EBI-724076, EBI-1052725;
CC Q99750; Q99757: TXN2; NbExp=3; IntAct=EBI-724076, EBI-2932492;
CC Q99750; Q8TAI1: TYMSOS; NbExp=4; IntAct=EBI-724076, EBI-742060;
CC Q99750; Q06418: TYRO3; NbExp=3; IntAct=EBI-724076, EBI-3951628;
CC Q99750; A0A024R8A9: USP20; NbExp=3; IntAct=EBI-724076, EBI-14096082;
CC Q99750; Q9Y2K6: USP20; NbExp=3; IntAct=EBI-724076, EBI-2511991;
CC Q99750; Q6EMK4: VASN; NbExp=3; IntAct=EBI-724076, EBI-10249550;
CC Q99750; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-724076, EBI-11957216;
CC Q99750; P40337: VHL; NbExp=4; IntAct=EBI-724076, EBI-301246;
CC Q99750; P40337-2: VHL; NbExp=4; IntAct=EBI-724076, EBI-12157263;
CC Q99750; Q15906: VPS72; NbExp=4; IntAct=EBI-724076, EBI-399189;
CC Q99750; Q8IW00: VSTM4; NbExp=3; IntAct=EBI-724076, EBI-4311759;
CC Q99750; O96014: WNT11; NbExp=9; IntAct=EBI-724076, EBI-8058160;
CC Q99750; P25490: YY1; NbExp=3; IntAct=EBI-724076, EBI-765538;
CC Q99750; O43167: ZBTB24; NbExp=11; IntAct=EBI-724076, EBI-744471;
CC Q99750; P24278: ZBTB25; NbExp=2; IntAct=EBI-724076, EBI-739899;
CC Q99750; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-724076, EBI-12287587;
CC Q99750; Q96C00: ZBTB9; NbExp=6; IntAct=EBI-724076, EBI-395708;
CC Q99750; Q7Z2W4: ZC3HAV1; NbExp=3; IntAct=EBI-724076, EBI-922540;
CC Q99750; Q8WTX9: ZDHHC1; NbExp=3; IntAct=EBI-724076, EBI-2818796;
CC Q99750; Q68DK2-5: ZFYVE26; NbExp=7; IntAct=EBI-724076, EBI-8656416;
CC Q99750; Q9NZV7: ZIM2; NbExp=3; IntAct=EBI-724076, EBI-11962760;
CC Q99750; Q8IZC7: ZNF101; NbExp=6; IntAct=EBI-724076, EBI-5278328;
CC Q99750; P17014: ZNF12; NbExp=3; IntAct=EBI-724076, EBI-11278550;
CC Q99750; Q15973: ZNF124; NbExp=6; IntAct=EBI-724076, EBI-2555767;
CC Q99750; P52737: ZNF136; NbExp=12; IntAct=EBI-724076, EBI-749129;
CC Q99750; P52744: ZNF138; NbExp=3; IntAct=EBI-724076, EBI-10746567;
CC Q99750; P52744-2: ZNF138; NbExp=3; IntAct=EBI-724076, EBI-10213071;
CC Q99750; Q12901: ZNF155; NbExp=3; IntAct=EBI-724076, EBI-10747670;
CC Q99750; Q12901-2: ZNF155; NbExp=3; IntAct=EBI-724076, EBI-10227379;
CC Q99750; Q9UK13: ZNF221; NbExp=3; IntAct=EBI-724076, EBI-14513896;
CC Q99750; Q9UK11: ZNF223; NbExp=7; IntAct=EBI-724076, EBI-10322867;
CC Q99750; P17027: ZNF23; NbExp=3; IntAct=EBI-724076, EBI-5657766;
CC Q99750; Q9UIE0: ZNF230; NbExp=3; IntAct=EBI-724076, EBI-1105361;
CC Q99750; O43296: ZNF264; NbExp=3; IntAct=EBI-724076, EBI-4395808;
CC Q99750; Q14C61: ZNF264; NbExp=3; IntAct=EBI-724076, EBI-2826570;
CC Q99750; Q14584: ZNF266; NbExp=6; IntAct=EBI-724076, EBI-7115319;
CC Q99750; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-724076, EBI-373456;
CC Q99750; Q9H9D4: ZNF408; NbExp=6; IntAct=EBI-724076, EBI-347633;
CC Q99750; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-724076, EBI-744257;
CC Q99750; Q8TAU3: ZNF417; NbExp=7; IntAct=EBI-724076, EBI-740727;
CC Q99750; Q8N7K0: ZNF433; NbExp=3; IntAct=EBI-724076, EBI-10267553;
CC Q99750; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-724076, EBI-11962468;
CC Q99750; Q8NDP4: ZNF439; NbExp=8; IntAct=EBI-724076, EBI-747580;
CC Q99750; Q8IYI8: ZNF440; NbExp=10; IntAct=EBI-724076, EBI-726439;
CC Q99750; Q8N8Z8: ZNF441; NbExp=3; IntAct=EBI-724076, EBI-17216366;
CC Q99750; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-724076, EBI-740232;
CC Q99750; Q8TAF7: ZNF461; NbExp=3; IntAct=EBI-724076, EBI-10271693;
CC Q99750; Q96JC4: ZNF479; NbExp=3; IntAct=EBI-724076, EBI-10820574;
CC Q99750; Q9ULM2: ZNF490; NbExp=7; IntAct=EBI-724076, EBI-1105370;
CC Q99750; Q8N8L2: ZNF491; NbExp=5; IntAct=EBI-724076, EBI-12019860;
CC Q99750; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-724076, EBI-10486136;
CC Q99750; Q96KM6: ZNF512B; NbExp=3; IntAct=EBI-724076, EBI-1049952;
CC Q99750; Q96C55: ZNF524; NbExp=3; IntAct=EBI-724076, EBI-10283126;
CC Q99750; Q9BR84: ZNF559; NbExp=8; IntAct=EBI-724076, EBI-746605;
CC Q99750; Q8TBZ8: ZNF564; NbExp=6; IntAct=EBI-724076, EBI-10273713;
CC Q99750; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-724076, EBI-10172590;
CC Q99750; Q86XF7: ZNF575; NbExp=3; IntAct=EBI-724076, EBI-14069183;
CC Q99750; Q3MI94: ZNF578; NbExp=3; IntAct=EBI-724076, EBI-10241108;
CC Q99750; Q96N58: ZNF578; NbExp=3; IntAct=EBI-724076, EBI-11955189;
CC Q99750; Q9UK33: ZNF580; NbExp=3; IntAct=EBI-724076, EBI-746277;
CC Q99750; Q9P0T4: ZNF581; NbExp=8; IntAct=EBI-724076, EBI-745520;
CC Q99750; Q96SQ5: ZNF587; NbExp=8; IntAct=EBI-724076, EBI-6427977;
CC Q99750; Q96SK3: ZNF607; NbExp=4; IntAct=EBI-724076, EBI-747175;
CC Q99750; Q6PF04: ZNF613; NbExp=3; IntAct=EBI-724076, EBI-12062855;
CC Q99750; O15015: ZNF646; NbExp=3; IntAct=EBI-724076, EBI-745608;
CC Q99750; Q5T619: ZNF648; NbExp=5; IntAct=EBI-724076, EBI-11985915;
CC Q99750; Q6ZS27-3: ZNF662; NbExp=3; IntAct=EBI-724076, EBI-10255155;
CC Q99750; Q96BR6: ZNF669; NbExp=3; IntAct=EBI-724076, EBI-12006574;
CC Q99750; Q9BS34: ZNF670; NbExp=5; IntAct=EBI-724076, EBI-745276;
CC Q99750; Q8IYX0: ZNF679; NbExp=4; IntAct=EBI-724076, EBI-745567;
CC Q99750; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-724076, EBI-16429014;
CC Q99750; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-724076, EBI-11090299;
CC Q99750; Q96C28: ZNF707; NbExp=5; IntAct=EBI-724076, EBI-748111;
CC Q99750; Q96H86: ZNF764; NbExp=4; IntAct=EBI-724076, EBI-745775;
CC Q99750; Q8NCA9: ZNF784; NbExp=3; IntAct=EBI-724076, EBI-7138303;
CC Q99750; A8K8V0: ZNF785; NbExp=3; IntAct=EBI-724076, EBI-3925400;
CC Q99750; Q8N393: ZNF786; NbExp=3; IntAct=EBI-724076, EBI-10265203;
CC Q99750; Q15937: ZNF79; NbExp=3; IntAct=EBI-724076, EBI-10237274;
CC Q99750; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-724076, EBI-11962574;
CC Q99750; Q08AG5: ZNF844; NbExp=6; IntAct=EBI-724076, EBI-10225757;
CC Q99750; O43257: ZNHIT1; NbExp=3; IntAct=EBI-724076, EBI-347522;
CC Q99750; Q5BKY6; NbExp=3; IntAct=EBI-724076, EBI-10243533;
CC Q99750; Q5W150; NbExp=3; IntAct=EBI-724076, EBI-10248148;
CC Q99750; Q5XG85; NbExp=3; IntAct=EBI-724076, EBI-10248413;
CC Q99750; P09022: Hoxa1; Xeno; NbExp=3; IntAct=EBI-724076, EBI-3957603;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MDFI family. {ECO:0000305}.
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DR EMBL; U78313; AAB39748.1; -; mRNA.
DR EMBL; AL035588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC007836; AAH07836.1; -; mRNA.
DR CCDS; CCDS4857.1; -.
DR RefSeq; NP_001287733.1; NM_001300804.1.
DR RefSeq; NP_001287734.1; NM_001300805.1.
DR RefSeq; NP_001287735.1; NM_001300806.1.
DR RefSeq; NP_005577.1; NM_005586.3.
DR AlphaFoldDB; Q99750; -.
DR BioGRID; 110353; 518.
DR IntAct; Q99750; 409.
DR MINT; Q99750; -.
DR STRING; 9606.ENSP00000230321; -.
DR iPTMnet; Q99750; -.
DR PhosphoSitePlus; Q99750; -.
DR BioMuta; MDFI; -.
DR DMDM; 25090674; -.
DR MassIVE; Q99750; -.
DR MaxQB; Q99750; -.
DR PaxDb; Q99750; -.
DR PeptideAtlas; Q99750; -.
DR PRIDE; Q99750; -.
DR ProteomicsDB; 78457; -.
DR Antibodypedia; 30051; 168 antibodies from 30 providers.
DR DNASU; 4188; -.
DR Ensembl; ENST00000230321.11; ENSP00000230321.6; ENSG00000112559.15.
DR Ensembl; ENST00000373051.6; ENSP00000362142.2; ENSG00000112559.15.
DR GeneID; 4188; -.
DR KEGG; hsa:4188; -.
DR MANE-Select; ENST00000230321.11; ENSP00000230321.6; NM_005586.4; NP_005577.1.
DR UCSC; uc003oqq.5; human.
DR CTD; 4188; -.
DR DisGeNET; 4188; -.
DR GeneCards; MDFI; -.
DR HGNC; HGNC:6967; MDFI.
DR HPA; ENSG00000112559; Tissue enhanced (esophagus).
DR MIM; 604971; gene.
DR neXtProt; NX_Q99750; -.
DR OpenTargets; ENSG00000112559; -.
DR PharmGKB; PA30713; -.
DR VEuPathDB; HostDB:ENSG00000112559; -.
DR eggNOG; ENOG502RZMC; Eukaryota.
DR GeneTree; ENSGT00940000160187; -.
DR HOGENOM; CLU_067479_1_0_1; -.
DR InParanoid; Q99750; -.
DR OMA; CAECDLP; -.
DR OrthoDB; 1487193at2759; -.
DR PhylomeDB; Q99750; -.
DR TreeFam; TF332113; -.
DR PathwayCommons; Q99750; -.
DR SignaLink; Q99750; -.
DR SIGNOR; Q99750; -.
DR BioGRID-ORCS; 4188; 8 hits in 1046 CRISPR screens.
DR ChiTaRS; MDFI; human.
DR GeneWiki; MDFI; -.
DR GenomeRNAi; 4188; -.
DR Pharos; Q99750; Tbio.
DR PRO; PR:Q99750; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q99750; protein.
DR Bgee; ENSG00000112559; Expressed in ganglionic eminence and 132 other tissues.
DR ExpressionAtlas; Q99750; baseline and differential.
DR Genevisible; Q99750; HS.
DR GO; GO:0005737; C:cytoplasm; TAS:ProtInc.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0140416; F:transcription regulator inhibitor activity; TAS:GO_Central.
DR GO; GO:0042994; P:cytoplasmic sequestering of transcription factor; TAS:ProtInc.
DR GO; GO:0009950; P:dorsal/ventral axis specification; ISS:UniProtKB.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR GO; GO:0043392; P:negative regulation of DNA binding; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0060707; P:trophoblast giant cell differentiation; IEA:Ensembl.
DR InterPro; IPR026134; MDFI/MDFIC.
DR PANTHER; PTHR15304; PTHR15304; 1.
DR Pfam; PF15316; MDFI; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Developmental protein; Differentiation; Nucleus;
KW Reference proteome.
FT CHAIN 1..246
FT /note="MyoD family inhibitor"
FT /id="PRO_0000096324"
FT DOMAIN 99..246
FT /note="MDFI"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 246 AA; 25029 MW; 9330E52141B79E5A CRC64;
MYQVSGQRPS GCDAPYGAPS AAPGPAQTLS LLPGLEVVTG STHPAEAAPE EGSLEEAATP
MPQGNGPGIP QGLDSTDLDV PTEAVTCQPQ GNPLGCTPLL PNDSGHPSEL GGTRRAGNGA
LGGPKAHRKL QTHPSLASQG SKKSKSSSKS TTSQIPLQAQ EDCCVHCILS CLFCEFLTLC
NIVLDCATCG SCSSEDSCLC CCCCGSGECA DCDLPCDLDC GILDACCESA DCLEICMECC
GLCFSS
