ID   MDH1B_BOVIN             Reviewed;         473 AA.
AC   A3KMX7;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Putative malate dehydrogenase 1B;
DE            EC=1.1.1.-;
GN   Name=MDH1B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC       {ECO:0000305}.
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DR   EMBL; BC133372; AAI33373.1; -; mRNA.
DR   RefSeq; NP_001076921.1; NM_001083452.1.
DR   AlphaFoldDB; A3KMX7; -.
DR   SMR; A3KMX7; -.
DR   STRING; 9913.ENSBTAP00000038086; -.
DR   PaxDb; A3KMX7; -.
DR   PRIDE; A3KMX7; -.
DR   Ensembl; ENSBTAT00000038271; ENSBTAP00000038086; ENSBTAG00000016192.
DR   GeneID; 527943; -.
DR   KEGG; bta:527943; -.
DR   CTD; 130752; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016192; -.
DR   VGNC; VGNC:31334; MDH1B.
DR   eggNOG; KOG1496; Eukaryota.
DR   GeneTree; ENSGT00530000063410; -.
DR   HOGENOM; CLU_040727_2_3_1; -.
DR   InParanoid; A3KMX7; -.
DR   OrthoDB; 588276at2759; -.
DR   TreeFam; TF329007; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000016192; Expressed in semen and 89 other tissues.
DR   ExpressionAtlas; A3KMX7; baseline.
DR   GO; GO:0030060; F:L-malate dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0006108; P:malate metabolic process; IBA:GO_Central.
DR   GO; GO:0006734; P:NADH metabolic process; IBA:GO_Central.
DR   GO; GO:0006107; P:oxaloacetate metabolic process; IBA:GO_Central.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR   Gene3D; 3.90.110.10; -; 1.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR010945; Malate_DH_type2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23382; PTHR23382; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF56327; SSF56327; 1.
PE   2: Evidence at transcript level;
KW   NAD; Oxidoreductase; Reference proteome; Tricarboxylic acid cycle.
FT   CHAIN           1..473
FT                   /note="Putative malate dehydrogenase 1B"
FT                   /id="PRO_0000331434"
SQ   SEQUENCE   473 AA;  53088 MW;  27861A2D05BC37E5 CRC64;
     MAKFVLAGRA DCPYYAKAEL LADYLQKNLP DFRIHKITQH PDIWEEWLKD LCKKNRWSHN
     KSPIIWRELL DRGGKGLLLG GYNEFLEHAQ LYYGVTSSMT TELMKRVAQE NLGTHIEKEL
     EKESLKGLVN PLQVWITSAS SLACYHLIPI LTSGEVFGPQ MEISINLFDN KHTEEKLISH
     KQEAEDLASP CLQSVSICTQ AEEAFHGAHV IIILDDHVDK EINSLEDCIR SRAPLCQLYG
     SLIEKNAHNF AKIIVGGKTF VNLKTALLMK YAPTFAHNII AVALGVEGQA KAALARKLKI
     TPSCIKDVII WGNISGNNYV DLRKAKVYRY ESAIWGPPHY SRPVLSLLFD REWVNREFVV
     SLKTLTATGR QFGGMLAAHS IATTLKYWCH GSPPGEIVSL GVLSEGQFGI PKGIVFSMPV
     KFENGTWVVL TDLKNTEISQ QVMTRMANDL IQEQLVALGE LANFQPYQSE NLI