ID   MDH1B_BRAFL             Reviewed;         522 AA.
AC   Q8T773;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Putative malate dehydrogenase 1B;
DE            EC=1.1.1.-;
GN   Name=MDH1B;
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11967531; DOI=10.1038/ng855;
RA   Abi-Rached L., Gilles A., Shiina T., Pontarotti P., Inoko H.;
RT   "Evidence of en bloc duplication in vertebrate genomes.";
RL   Nat. Genet. 31:100-105(2002).
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC       {ECO:0000305}.
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DR   EMBL; AF391289; AAM18871.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8T773; -.
DR   SMR; Q8T773; -.
DR   STRING; 7739.XP_002612869.1; -.
DR   eggNOG; KOG1496; Eukaryota.
DR   GO; GO:0016615; F:malate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.110.10; -; 1.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR010945; Malate_DH_type2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23382; PTHR23382; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF56327; SSF56327; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..522
FT                   /note="Putative malate dehydrogenase 1B"
FT                   /id="PRO_0000331437"
FT   REGION          495..522
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   522 AA;  57796 MW;  886C1197306F879E CRC64;
     MAKFVIAGQA DCPYYAKVEL LADSLQSKLQ DFHVHKIVKT PEEWKPWLQQ LCADNGWTHG
     RSPIIWRELV DRGGKGLLIG GHNDFMEYAR SYYGMTSGML SEMMKNIAAE NLAVTQELRE
     EEETIRRQSK PLHVCVINAA RSPAYHVLPS LVNGKILREE EIALHLHDSE ENLEKLKGLE
     MEVFDLSFPF LKEISVTTDL PTAFQNAHIA IVLDDFDQGG KEDAIGDMET KVSFYKRVAE
     AINQTASKDI RVLVAGTGPL NSLVSILIDH TPSIPRQNIA AVAQVKERQA KSLLAKRLTV
     NSAGVCDVIV WGNVGGTTYT DVSRARVHGY DGAIWGPPSY SCSVSEMVHD NKWLEGEFLE
     QLQSRSHTIQ DSLQHSADLS MAAAISSTLS YWWNGSPEGQ LFSLAVCSEG FYNIPEGVVF
     SFPVMFHKGS WEVVQDIDMN EDMRVMLSSI TAQLVEEKDL LLHPTNANHE KLLKVFGVTT
     DISTPSSVKL DKIMEETEKS SSEDTPEAAA AAVSTGDETV PS