ID   MDHM_CAPAA              Reviewed;          35 AA.
AC   P86074;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 23.
DE   RecName: Full=Malate dehydrogenase, mitochondrial {ECO:0000250|UniProtKB:P17783};
DE            EC=1.1.1.37;
DE   Flags: Fragments;
OS   Capsicum annuum var. annuum (Red pepper).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX   NCBI_TaxID=40321;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RA   Almagro L., Sabater Jara A.B., Pedreno M.A.;
RL   Submitted (JUL-2008) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate;
CC         Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.37;
CC         Evidence={ECO:0000250|UniProtKB:P17783, ECO:0000255|PROSITE-
CC         ProRule:PRU10004};
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P17783}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:P17783}.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 1 family.
CC       {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P86074; -.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase;
KW   Tricarboxylic acid cycle.
FT   CHAIN           <1..>35
FT                   /note="Malate dehydrogenase, mitochondrial"
FT                   /id="PRO_0000362993"
FT   BINDING         7
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:P61889"
FT   BINDING         23
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P61889,
FT                   ECO:0000255|PROSITE-ProRule:PRU10004"
FT   UNSURE          3
FT                   /note="L or I"
FT   UNSURE          4
FT                   /note="F or M"
FT   UNSURE          6
FT                   /note="I or L"
FT   UNSURE          10
FT                   /note="I or L"
FT   UNSURE          12
FT                   /note="K or Q"
FT   UNSURE          13
FT                   /note="L or I"
FT   UNSURE          14
FT                   /note="F or M"
FT   UNSURE          19
FT                   /note="L or I"
FT   UNSURE          25
FT                   /note="Q or K"
FT   UNSURE          35
FT                   /note="K or Q"
FT   NON_CONS        12..13
FT                   /evidence="ECO:0000305"
FT   NON_CONS        23..24
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         35
SQ   SEQUENCE   35 AA;  3735 MW;  916AB5BAFDA5953D CRC64;
     DDLFNINAGI VKLFGVTTLD VVRTQDGGTE VVEAK