MDH_DELAC
ID MDH_DELAC Reviewed; 19 AA.
AC P80539;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Malate dehydrogenase;
DE EC=1.1.1.37;
DE Flags: Fragment;
GN Name=mdh;
OS Delftia acidovorans (Pseudomonas acidovorans) (Comamonas acidovorans).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Delftia.
OX NCBI_TaxID=80866;
RN [1]
RP PROTEIN SEQUENCE.
RC STRAIN=ATCC 15668 / DSM 39 / BCRC 14819 / JCM 5833 / NBRC 14950 / NCIMB
RC 9681 / NCTC 10683 / 2167;
RX PubMed=9190829; DOI=10.1128/jb.179.12.4066-4070.1997;
RA Charnock C.;
RT "Structural studies of malate dehydrogenases (MDHs): MDHs in Brevundimonas
RT species are the first reported MDHs in Proteobacteria which resemble
RT lactate dehydrogenases in primary structure.";
RL J. Bacteriol. 179:4066-4070(1997).
CC -!- FUNCTION: Catalyzes the reversible oxidation of malate to oxaloacetate.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate;
CC Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.37;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10004};
CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC {ECO:0000305}.
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DR GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Direct protein sequencing; NAD; Oxidoreductase; Tricarboxylic acid cycle.
FT CHAIN 1..>19
FT /note="Malate dehydrogenase"
FT /id="PRO_0000113361"
FT BINDING 11..17
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT NON_TER 19
SQ SEQUENCE 19 AA; 1853 MW; AE00010E81190716 CRC64;
XKKPVXVAVT GAAGQIGYA