ID   ARGR_GEOSE              Reviewed;         149 AA.
AC   O31408;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Arginine repressor;
GN   Name=argR;
OS   Geobacillus stearothermophilus (Bacillus stearothermophilus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=1422;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NCIMB 8224 / CCM 2186 / NCA C-1235.1 / VKM B-718;
RX   PubMed=9282750; DOI=10.1046/j.1365-2958.1997.4781845.x;
RA   Dion M., Charlier D.R.M., Wang H., Gigot D., Savchenko A., Hallet J.-N.,
RA   Glansdorff N., Sakanyan V.;
RT   "The highly thermostable arginine repressor of Bacillus stearothermophilus:
RT   gene cloning and repressor-operator interactions.";
RL   Mol. Microbiol. 25:385-398(1997).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RX   PubMed=10331868; DOI=10.1038/8229;
RA   Ni J., Sakanyan V., Charlier D., Glansdorff N., van Duyne G.D.;
RT   "Structure of the arginine repressor from Bacillus stearothermophilus.";
RL   Nat. Struct. Biol. 6:427-432(1999).
CC   -!- FUNCTION: Regulates arginine biosynthesis genes.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis [regulation].
CC   -!- SUBUNIT: Homohexamer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ArgR family. {ECO:0000305}.
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DR   EMBL; Y09546; CAA70737.1; -; Genomic_DNA.
DR   PDB; 1B4A; X-ray; 2.50 A; A/B/C/D/E/F=2-149.
DR   PDB; 1B4B; X-ray; 2.20 A; A/B/C=79-149.
DR   PDBsum; 1B4A; -.
DR   PDBsum; 1B4B; -.
DR   AlphaFoldDB; O31408; -.
DR   SMR; O31408; -.
DR   UniPathway; UPA00068; -.
DR   EvolutionaryTrace; O31408; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0034618; F:arginine binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0051259; P:protein complex oligomerization; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00173; Arg_repressor; 1.
DR   InterPro; IPR001669; Arg_repress.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR036251; Arg_repress_C_sf.
DR   InterPro; IPR020900; Arg_repress_DNA-bd.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34471; PTHR34471; 1.
DR   Pfam; PF01316; Arg_repressor; 1.
DR   Pfam; PF02863; Arg_repressor_C; 1.
DR   PRINTS; PR01467; ARGREPRESSOR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF55252; SSF55252; 1.
DR   TIGRFAMs; TIGR01529; argR_whole; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..149
FT                   /note="Arginine repressor"
FT                   /id="PRO_0000205071"
FT   HELIX           5..16
FT                   /evidence="ECO:0007829|PDB:1B4A"
FT   HELIX           22..31
FT                   /evidence="ECO:0007829|PDB:1B4A"
FT   HELIX           38..47
FT                   /evidence="ECO:0007829|PDB:1B4A"
FT   STRAND          51..54
FT                   /evidence="ECO:0007829|PDB:1B4A"
FT   STRAND          56..58
FT                   /evidence="ECO:0007829|PDB:1B4A"
FT   STRAND          60..63
FT                   /evidence="ECO:0007829|PDB:1B4A"
FT   STRAND          68..70
FT                   /evidence="ECO:0007829|PDB:1B4A"
FT   HELIX           80..83
FT                   /evidence="ECO:0007829|PDB:1B4B"
FT   STRAND          84..90
FT                   /evidence="ECO:0007829|PDB:1B4B"
FT   STRAND          93..99
FT                   /evidence="ECO:0007829|PDB:1B4B"
FT   HELIX           103..113
FT                   /evidence="ECO:0007829|PDB:1B4B"
FT   STRAND          118..123
FT                   /evidence="ECO:0007829|PDB:1B4B"
FT   STRAND          125..134
FT                   /evidence="ECO:0007829|PDB:1B4B"
FT   HELIX           135..146
FT                   /evidence="ECO:0007829|PDB:1B4B"
SQ   SEQUENCE   149 AA;  16805 MW;  F15E1ACD89E006E8 CRC64;
     MNKGQRHIKI REIIMSNDIE TQDELVDRLR EAGFNVTQAT VSRDIKEMQL VKVPMANGRY
     KYSLPSDQRF NPLQKLKRAL VDVFIKLDGT GNLLVLRTLP GNAHAIGVLL DNLDWDEIVG
     TICGDDTCLI ICRTPKDAKK VSNQLLSML