ID   MDH_NITAL               Reviewed;          32 AA.
AC   P10887;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Malate dehydrogenase;
DE            EC=1.1.1.37;
DE   Flags: Fragment;
OS   Nitzschia alba (Marine diatom).
OC   Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC   Bacillariophyceae; Bacillariophycidae; Bacillariales; Bacillariaceae;
OC   Nitzschia.
OX   NCBI_TaxID=2858;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2930509; DOI=10.1042/bj2580221;
RA   Yueh A.Y., Chung C.-S., Lai Y.-K.;
RT   "Purification and molecular properties of malate dehydrogenase from the
RT   marine diatom Nitzschia alba.";
RL   Biochem. J. 258:221-228(1989).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate;
CC         Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.37;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10004};
CC   -!- SUBUNIT: Homooctamer. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 1 family.
CC       {ECO:0000305}.
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DR   PIR; S03352; S03352.
DR   AlphaFoldDB; P10887; -.
DR   SMR; P10887; -.
DR   GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; NAD; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..>32
FT                   /note="Malate dehydrogenase"
FT                   /id="PRO_0000113341"
FT   NON_TER         32
SQ   SEQUENCE   32 AA;  3326 MW;  83F0E9E0BAADB4C2 CRC64;
     RKVAVMGAAG GIGQPLSLLL KLSPQVTELS KY