ID   MDH_PHEIM               Reviewed;          25 AA.
AC   P19980;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Malate dehydrogenase;
DE            EC=1.1.1.37;
DE   Flags: Fragment;
GN   Name=mdh;
OS   Phenylobacterium immobile.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Phenylobacterium.
OX   NCBI_TaxID=21;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=E;
RX   PubMed=2775496; DOI=10.1515/bchm3.1989.370.2.763;
RA   Rommel T.O., Hund H.-K., Speth A.R., Lingens F.;
RT   "Purification and N-terminal amino-acid sequences of bacterial malate
RT   dehydrogenases from six actinomycetales strains and from Phenylobacterium
RT   immobile, strain E.";
RL   Biol. Chem. Hoppe-Seyler 370:763-768(1989).
CC   -!- FUNCTION: Catalyzes the reversible oxidation of malate to oxaloacetate.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate;
CC         Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.37;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10004};
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC       {ECO:0000305}.
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DR   PIR; S07574; S07574.
DR   AlphaFoldDB; P19980; -.
DR   SMR; P19980; -.
DR   GO; GO:0030060; F:L-malate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; NAD; Oxidoreductase; Tricarboxylic acid cycle.
FT   CHAIN           1..>25
FT                   /note="Malate dehydrogenase"
FT                   /id="PRO_0000113385"
FT   BINDING         11..17
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   NON_TER         25
SQ   SEQUENCE   25 AA;  2626 MW;  C8D81E008825845C CRC64;
     SKTPIRVAVT GAAGNIGYHL LFRIA