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MDJ1_EMENI
ID   MDJ1_EMENI              Reviewed;         547 AA.
AC   C8V213; Q5AZT6; Q6XPR4;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DnaJ homolog 1, mitochondrial;
DE   Flags: Precursor;
GN   ORFNames=AN10778;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA57980.1; Type=Erroneous gene model prediction; Note=The predicted gene AN6194 has been split into 2 genes: AN10778 and AN10788.; Evidence={ECO:0000305};
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DR   EMBL; AACD01000105; EAA57980.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001301; CBF69996.1; -; Genomic_DNA.
DR   RefSeq; XP_663798.1; XM_658706.1.
DR   AlphaFoldDB; C8V213; -.
DR   SMR; C8V213; -.
DR   STRING; 162425.CADANIAP00006815; -.
DR   PRIDE; C8V213; -.
DR   EnsemblFungi; CBF69996; CBF69996; ANIA_10778.
DR   EnsemblFungi; EAA57980; EAA57980; AN6194.2.
DR   GeneID; 2870728; -.
DR   KEGG; ani:AN6194.2; -.
DR   eggNOG; KOG0715; Eukaryota.
DR   HOGENOM; CLU_003661_1_0_1; -.
DR   InParanoid; C8V213; -.
DR   OMA; DLHCTVT; -.
DR   OrthoDB; 894595at2759; -.
DR   Proteomes; UP000000560; Chromosome I.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IEA:EnsemblFungi.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0001671; F:ATPase activator activity; IEA:EnsemblFungi.
DR   GO; GO:0031072; F:heat shock protein binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:EnsemblFungi.
DR   GO; GO:0006515; P:protein quality control for misfolded or incompletely synthesized proteins; IEA:EnsemblFungi.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   GO; GO:0009408; P:response to heat; IEA:EnsemblFungi.
DR   CDD; cd06257; DnaJ; 1.
DR   CDD; cd10719; DnaJ_zf; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   HAMAP; MF_01152; DnaJ; 1.
DR   InterPro; IPR012724; DnaJ.
DR   InterPro; IPR002939; DnaJ_C.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR008971; HSP40/DnaJ_pept-bd.
DR   InterPro; IPR001305; HSP_DnaJ_Cys-rich_dom.
DR   InterPro; IPR036410; HSP_DnaJ_Cys-rich_dom_sf.
DR   InterPro; IPR036869; J_dom_sf.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF01556; DnaJ_C; 1.
DR   Pfam; PF00684; DnaJ_CXXCXGXG; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   SUPFAM; SSF49493; SSF49493; 2.
DR   SUPFAM; SSF57938; SSF57938; 1.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
DR   PROSITE; PS51188; ZF_CR; 1.
PE   3: Inferred from homology;
KW   Chaperone; Metal-binding; Mitochondrion; Reference proteome; Repeat;
KW   Transit peptide; Zinc; Zinc-finger.
FT   TRANSIT         1..79
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           80..547
FT                   /note="DnaJ homolog 1, mitochondrial"
FT                   /id="PRO_0000413169"
FT   DOMAIN          83..147
FT                   /note="J"
FT   REPEAT          253..260
FT                   /note="CXXCXGXG motif"
FT   REPEAT          270..277
FT                   /note="CXXCXGXG motif"
FT   REPEAT          293..300
FT                   /note="CXXCXGXG motif"
FT   REPEAT          309..316
FT                   /note="CXXCXGXG motif"
FT   ZN_FING         240..321
FT                   /note="CR-type"
FT   REGION          484..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        522..539
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   547 AA;  57632 MW;  622E0C8E49EECCC9 CRC64;
     MNPSSALMPK ATAIPGCILR TSRQCSKHNQ TSGIRASSST RQYHVAAIES PARRRRDSTF
     MKRSDFIQAR NFHATKVLAA IPDPYKVLGV DKGASAGDIK KAYYGMAKKY HPDTNKDPGA
     KEKFAEAQSA YELLSDKKKR ETYDRFGSAA FDQNGGFDPS AGAGGNPFAG GGGFHGFGGG
     FGGGFPGGFA ADINIEDLFG AFAGGARRSG RGRRGPFQEI LVGEDIEVQT NISFMEAAKG
     TSQDIVITPL KECGTCKGDG LKEGAKRTQC RQCNGTGTRV HLMQGGFQVA ATCDACGGAG
     LIVPRGSHCG TCKGDGVVRE RKTVRVDIPG GVEDGMRLRI SGEGDAPPTG TAAAPGTRTQ
     RGDLYVSIRV SPDERFSRSG SDILYTASIP LTTALLGGEV LVPTLDGQVK VKVATGTGTG
     DRITLSGMGM KKLGGRSRGF SPNGDLKVEF KVAMPKYLTS NQRTILEVLA DEMGDKTARR
     IMDIPRDGLS TAPAADASSG NESKSEGFLK SAWHKLMNHK KPAGSENSSD SSSNKDSNSS
     GDSKKSE
 
 
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