ID   MDLA_BUCAI              Reviewed;         589 AA.
AC   P57551;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Multidrug resistance-like ATP-binding protein MdlA;
DE            EC=7.6.2.2;
GN   Name=mdlA; OrderedLocusNames=BU479;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate +
CC         xenobioticSide 2.; EC=7.6.2.2;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Drug exporter-2
CC       (TC 3.A.1.117) family. {ECO:0000305}.
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DR   EMBL; BA000003; BAB13176.1; -; Genomic_DNA.
DR   RefSeq; NP_240290.1; NC_002528.1.
DR   RefSeq; WP_010896138.1; NC_002528.1.
DR   AlphaFoldDB; P57551; -.
DR   SMR; P57551; -.
DR   STRING; 107806.10039142; -.
DR   EnsemblBacteria; BAB13176; BAB13176; BAB13176.
DR   KEGG; buc:BU479; -.
DR   PATRIC; fig|107806.10.peg.488; -.
DR   eggNOG; COG1132; Bacteria.
DR   HOGENOM; CLU_000604_84_3_6; -.
DR   OMA; RVMHDLR; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008559; F:ABC-type xenobiotic transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1560.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039421; Type_1_exporter.
DR   PANTHER; PTHR24221; PTHR24221; 1.
DR   Pfam; PF00664; ABC_membrane; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF90123; SSF90123; 1.
DR   PROSITE; PS50929; ABC_TM1F; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW   Reference proteome; Translocase; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..589
FT                   /note="Multidrug resistance-like ATP-binding protein MdlA"
FT                   /id="PRO_0000092493"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          18..303
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          334..571
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         369..376
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   589 AA;  67522 MW;  AF736FA2FA60A56A CRC64;
     MKLFNQLRWF FVREWKRYLG AILLLIIIAT LQLLPPKIVG VLIDLIIKKN MHGVQILPWI
     LIIFLVAVIV YILRYLWRIL LFGASYQLAT ELRVKFYTYL SQQSQIFFLK NRTGDLIARA
     TNDVDRVVFA AGEGVLTLVD SLVMGFSVLI VMSTQISFLL TIISLIPMPI MAILIKKYGK
     ELHETFRHAQ ISFSLLNNQT QEILTSIRMI RAFGLEKNQS NKFNIITRNT GKKNMEVAKI
     DARFDPVIYL SVAFSNLLAI IGGGWLVWNN QISIGQLTSF IMYLGLMIWP MLALAWMFNI
     VERGSAAWDR IHSIINKKLY IEDGKNNIPP YPGILNINIK KFYYPNNQKP SLKDIRILIK
     PGNTLGICGP TGSGKSTLLM LIQRQFNFKK EEIHYHSLSL LEIKIDDWRR RIAVVNQTSF
     LFSDTISNNI SLGKPNASQK EIEEVAKLAD VHKDIIDLPE RYETQVGERG VMLSGGQKQR
     VCIARALLLN AEILILDDAL SAVDAQTENN ILKNINEWKK KKHSLIITTH RLSALINSDE
     IIVIKSGSII QRGNHLKLIQ EKNWYKSMYY YQQSEIELED NEKTGEKNL