ID   MDLA_BUCAP              Reviewed;         581 AA.
AC   Q8K985;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Multidrug resistance-like ATP-binding protein MdlA;
DE            EC=7.6.2.2;
GN   Name=mdlA; OrderedLocusNames=BUsg_464;
OS   Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=198804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sg;
RX   PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate +
CC         xenobioticSide 2.; EC=7.6.2.2;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Drug exporter-2
CC       (TC 3.A.1.117) family. {ECO:0000305}.
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DR   EMBL; AE013218; AAM68007.1; -; Genomic_DNA.
DR   RefSeq; WP_011053974.1; NC_004061.1.
DR   AlphaFoldDB; Q8K985; -.
DR   SMR; Q8K985; -.
DR   STRING; 198804.BUsg_464; -.
DR   EnsemblBacteria; AAM68007; AAM68007; BUsg_464.
DR   KEGG; bas:BUsg_464; -.
DR   eggNOG; COG1132; Bacteria.
DR   HOGENOM; CLU_000604_84_3_6; -.
DR   OMA; RVMHDLR; -.
DR   OrthoDB; 643917at2; -.
DR   Proteomes; UP000000416; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008559; F:ABC-type xenobiotic transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1560.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039421; Type_1_exporter.
DR   PANTHER; PTHR24221; PTHR24221; 1.
DR   Pfam; PF00664; ABC_membrane; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF90123; SSF90123; 1.
DR   PROSITE; PS50929; ABC_TM1F; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Translocase;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..581
FT                   /note="Multidrug resistance-like ATP-binding protein MdlA"
FT                   /id="PRO_0000092494"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        127..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        153..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          18..303
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          337..571
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         369..376
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   581 AA;  66160 MW;  004B5AC7FE5A7B96 CRC64;
     MRLFNQLKWY FIKEWKRYLG SIILLIIIAF LQLLPPKIIG ILIDLIIKEK MSGFEILPWI
     SIILLIAIIV YILRYLWRIL LFGASYQLAT ELRVKFYSYL SKQSEIFFLK NRTGDLIARA
     TNDVDRVVFA AGEGVLTLVD SSVMGISVLI VMITQISWLL TIISLIPMPI MAILIKKYGK
     KLHDTFRNAQ SAFSLLNNQT QEILTSIRMI RAFGLEKNQL KKFNNIVNDT GKKNMEVAEI
     DARFDPVIYL SVAFSNLLAI TAGGWLVWNN TITIGKLTSF IMYLGLMIWP MLALAWMFNI
     VERGSAAWDR IHSIINQNLY IEDGKKTIIN MNGKLNINID MFFYPKNKKP SLKNIYLSLN
     PGKTLGICGP TGAGKSTLLK LIQRQFKIHK GEILYNSSSL LELKIDYWRS KIGVVNQTSF
     LFSDSISNNI SLGKPKASQK EIEKAAKLAD IHKDIVCLPQ GYNTQVGERG VMLSGGQKQR
     IAIARALLLN TEILILDDAL SAVDGKTENN ILKNLKKWKD KGYSLIIVAH RLSALIHADE
     IIVIKEGTII QRGNHEKLIK EKNWYKSMYD HQKIQTEIEN F