ID   MDLA_BUCBP              Reviewed;         579 AA.
AC   Q89A97;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2003, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Multidrug resistance-like ATP-binding protein MdlA;
DE            EC=7.6.2.2;
GN   Name=mdlA; OrderedLocusNames=bbp_423;
OS   Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=224915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bp;
RX   PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA   van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA   Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA   Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT   "Reductive genome evolution in Buchnera aphidicola.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate +
CC         xenobioticSide 2.; EC=7.6.2.2;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Drug exporter-2
CC       (TC 3.A.1.117) family. {ECO:0000305}.
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DR   EMBL; AE016826; AAO27133.1; -; Genomic_DNA.
DR   RefSeq; WP_011091534.1; NC_004545.1.
DR   AlphaFoldDB; Q89A97; -.
DR   SMR; Q89A97; -.
DR   STRING; 224915.bbp_423; -.
DR   EnsemblBacteria; AAO27133; AAO27133; bbp_423.
DR   GeneID; 56470958; -.
DR   KEGG; bab:bbp_423; -.
DR   eggNOG; COG1132; Bacteria.
DR   HOGENOM; CLU_000604_84_6_6; -.
DR   OMA; RVMHDLR; -.
DR   OrthoDB; 643917at2; -.
DR   Proteomes; UP000000601; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008559; F:ABC-type xenobiotic transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1560.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039421; Type_1_exporter.
DR   PANTHER; PTHR24221; PTHR24221; 1.
DR   Pfam; PF00664; ABC_membrane; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF90123; SSF90123; 1.
DR   PROSITE; PS50929; ABC_TM1F; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW   Reference proteome; Translocase; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..579
FT                   /note="Multidrug resistance-like ATP-binding protein MdlA"
FT                   /id="PRO_0000092495"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          18..303
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          338..572
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         370..377
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   579 AA;  66819 MW;  C75716750E436780 CRC64;
     MQLLKQLKWY FIQEYKNYTI AIFLLISISI LQLYPPKLIG MLIDISIRKQ TQKAPILPLI
     LIILFISIII YILRYMWRLF LFGASYKLAI KLRIEIYNYL CQQKNDFYLK HKTGDLIARI
     TNDVDKVVFA AGEGVLTLVD SLIMGVSVII VMITQISWKL TIISLIPMPI MAIIIKRFGK
     KLYSSYHDAQ TTFSHLNNYA QENLNNIHMI KAFGLENYYS KKFLKIAHKT RKKNIKIAKI
     DSKFNPIIHL FISISHLLAI TIGSYMITYN EISTGELMSF ILYLGLIIWP MLAFAWMFNI
     IERGSASWDR IKSMINNNLF IHKKKYKNIS NIPGILEVKI NYFKYSKSNK TILKNINFKI
     RPGQILGICG PTGSGKSTLL KLIQRQIELY DGKISYHSIP ITQFNIVEWR KKMSIVNQTT
     FLFSDTIANN IKLGKPYASQ KEIEQATTFS DLHNDIMTFP QGYNTQVGER GIMLSGGQKQ
     RISIARALLL KSEILILDNA LSSVDNKTEI NILENLKTWK KNKNTIIMCT HRLSSLINSD
     LIIVIENGSI TQIGKHKLLI QNLKQWYGKT YLHQKLSNH