ID   MDLB_BUCAI              Reviewed;         580 AA.
AC   P57552;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Multidrug resistance-like ATP-binding protein MdlB;
DE            EC=7.6.2.2;
GN   Name=mdlB; OrderedLocusNames=BU480;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate +
CC         xenobioticSide 2.; EC=7.6.2.2;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Drug exporter-2
CC       (TC 3.A.1.117) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB13177.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000003; BAB13177.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_240291.1; NC_002528.1.
DR   AlphaFoldDB; P57552; -.
DR   SMR; P57552; -.
DR   STRING; 107806.10039143; -.
DR   PRIDE; P57552; -.
DR   EnsemblBacteria; BAB13177; BAB13177; BAB13177.
DR   KEGG; buc:BU480; -.
DR   PATRIC; fig|107806.10.peg.489; -.
DR   eggNOG; COG1132; Bacteria.
DR   HOGENOM; CLU_000604_84_3_6; -.
DR   OMA; MSVMMAT; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008559; F:ABC-type xenobiotic transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1560.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039421; Type_1_exporter.
DR   PANTHER; PTHR24221; PTHR24221; 1.
DR   Pfam; PF00664; ABC_membrane; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF90123; SSF90123; 1.
DR   PROSITE; PS50929; ABC_TM1F; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW   Reference proteome; Translocase; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..580
FT                   /note="Multidrug resistance-like ATP-binding protein MdlB"
FT                   /id="PRO_0000092499"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          25..310
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          341..575
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         375..382
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   580 AA;  66403 MW;  BA2872BA2E76E200 CRC64;
     MNHLIAFWPI LKRLLIYVKP HKKKLILAFI FLLSGSTSEV LGPILISYFI NNILSKHQLH
     LLIILTIITL FIILQILSVF LNYFQSILFN KIAVESINKL RQDVMYAALQ QPISEFDSQP
     IGQMISKVTN DTEAVKELYD TVGPTLFRSI ILIFIILFAM FTLEWHMALV ALFILPLVIT
     IMLVYQYYST PLLRKVRYYL AEINNKFNET INGMNVIQQF CQQRRFQEKI KKSSDLHYMS
     RMKILRLDGF LLRPLLSLLS SMILCNFMFL FSFFPVGAFE VGVLYAFITY LGRLNEPLIA
     ITIQQSVLQQ SIVAGERIFS LIDSPKQKYG KNKDLLKSGK INIQNVSFYH KNCNKNILEN
     INIKISSKSF VAFVGHTGSG KSTLANLIMG YYPLKNGKIY LDDKSIDSIS HSVLRRNVLM
     VQQDPIVLSD TFFYNITLGR KIPEEKVWNI LDTVHLSDLV KSMPKGIYSL LGEEGNNLSV
     GQKQLLAIAR VLVAYPKVLI LDEATANIDS GTEQLIQKTL LSIRKNCTLI IIAHRLSTII
     EADSIIVLKK GKIVEFGTHE QLLTKKSCYY KMYKFQSCKF