ID   MDLB_BUCAP              Reviewed;         580 AA.
AC   Q8K984;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Multidrug resistance-like ATP-binding protein MdlB;
DE            EC=7.6.2.2;
GN   Name=mdlB; OrderedLocusNames=BUsg_465;
OS   Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=198804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sg;
RX   PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate +
CC         xenobioticSide 2.; EC=7.6.2.2;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Drug exporter-2
CC       (TC 3.A.1.117) family. {ECO:0000305}.
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DR   EMBL; AE013218; AAM68008.1; -; Genomic_DNA.
DR   RefSeq; WP_011053975.1; NC_004061.1.
DR   AlphaFoldDB; Q8K984; -.
DR   SMR; Q8K984; -.
DR   STRING; 198804.BUsg_465; -.
DR   EnsemblBacteria; AAM68008; AAM68008; BUsg_465.
DR   KEGG; bas:BUsg_465; -.
DR   eggNOG; COG1132; Bacteria.
DR   HOGENOM; CLU_000604_84_3_6; -.
DR   OMA; MSVMMAT; -.
DR   OrthoDB; 643917at2; -.
DR   Proteomes; UP000000416; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008559; F:ABC-type xenobiotic transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1560.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039421; Type_1_exporter.
DR   PANTHER; PTHR24221; PTHR24221; 1.
DR   Pfam; PF00664; ABC_membrane; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF90123; SSF90123; 1.
DR   PROSITE; PS50929; ABC_TM1F; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Translocase;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..580
FT                   /note="Multidrug resistance-like ATP-binding protein MdlB"
FT                   /id="PRO_0000092500"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          25..310
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          341..575
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         375..382
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   580 AA;  66171 MW;  4D0098F4F8571A2A CRC64;
     MDHLIQFWPI LKRLIIYAIP WKKKIILAFF LLLSGATSEV LGPILISYFI NNILSQHQLN
     FQLILIIIVI FIMLQILAVF FNYFQSILFN KIAVGIVNKL RNDVMKAALN QPISEFDSQP
     IGQMISKVTN DTEVIKELYD TVGPTFFRSI TLIIIILFAM FTLEWHMAII TIFIIPLVII
     VMSIYQYYST PLLRNVRYYV ANINNKFNET INGMNVIQQF RQQTRFENNI KESSELHYLA
     RMKILKLDGF LLRPLLSLLS ALVLCSFMFL FSYFSIGVYE VGVLYAFITY LGRLNEPLIS
     ITIQQSILQQ AIVAGERIFS LIDSPKQKYG NNEEEIKSGK INIKNLSFKY KESGENILNN
     INIYIPSKSF VAFVGQTGSG KSTLANLLMG YYPIKHGKIY LDDKSINCIS HDVLRKNILM
     VQQDPIVLAD TFSSNITLGK KISEEKIWNV LKTVHLSSLV QSMPKGIYSI LGEEGNNLSL
     GQKQLLAIAR ILVRNPKILI LDEATANIDS GTEKLIQTTL SSIRAKTTLV VIAHRLSTVI
     EADMIVVLKK GKIVELGTHK QLLEKKGFYW KMYNFQLFNC