MDM10_PENRW
ID MDM10_PENRW Reviewed; 485 AA.
AC B6HL48;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Mitochondrial distribution and morphology protein 10 {ECO:0000255|HAMAP-Rule:MF_03102};
DE AltName: Full=Mitochondrial inheritance component mdm10 {ECO:0000255|HAMAP-Rule:MF_03102};
GN Name=mdm10; ORFNames=Pc21g03390;
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
CC -!- FUNCTION: Component of the ERMES/MDM complex, which serves as a
CC molecular tether to connect the endoplasmic reticulum and mitochondria.
CC Components of this complex are involved in the control of mitochondrial
CC shape and protein biogenesis and may function in phospholipid exchange.
CC mdm10 is involved in the late assembly steps of the general translocase
CC of the mitochondrial outer membrane (TOM complex). Functions in the
CC tom40-specific route of the assembly of outer membrane beta-barrel
CC proteins, including the association of tom40 with the receptor tom22
CC and small TOM proteins. Can associate with the SAM(core) complex as
CC well as the mdm12-mmm1 complex, both involved in late steps of the
CC major beta-barrel assembly pathway, that is responsible for biogenesis
CC of all outer membrane beta-barrel proteins. May act as a switch that
CC shuttles between both complexes and channels precursor proteins into
CC the tom40-specific pathway. Plays a role in mitochondrial morphology
CC and in the inheritance of mitochondria. {ECO:0000255|HAMAP-
CC Rule:MF_03102}.
CC -!- SUBUNIT: Component of the ER-mitochondria encounter structure (ERMES)
CC or MDM complex, composed of mmm1, mdm10, mdm12 and mdm34. Associates
CC with the mitochondrial outer membrane sorting assembly machinery
CC SAM(core) complex. {ECO:0000255|HAMAP-Rule:MF_03102}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000255|HAMAP-
CC Rule:MF_03102}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_03102}. Note=The ERMES/MDM complex localizes to a few discrete
CC foci (around 10 per single cell), that represent mitochondria-
CC endoplasmic reticulum junctions. These foci are often found next to
CC mtDNA nucleoids. {ECO:0000255|HAMAP-Rule:MF_03102}.
CC -!- DOMAIN: Lacks alpha-helical transmembrane segments, suggesting that it
CC resides in the membrane via beta-sheet conformations similar to those
CC predicted for other outer membrane proteins and porin.
CC -!- SIMILARITY: Belongs to the MDM10 family. {ECO:0000255|HAMAP-
CC Rule:MF_03102}.
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DR EMBL; AM920436; CAP95236.1; -; Genomic_DNA.
DR RefSeq; XP_002567403.1; XM_002567357.1.
DR AlphaFoldDB; B6HL48; -.
DR SMR; B6HL48; -.
DR STRING; 1108849.XP_002567403.1; -.
DR EnsemblFungi; CAP95236; CAP95236; PCH_Pc21g03390.
DR GeneID; 8313175; -.
DR KEGG; pcs:Pc21g03390; -.
DR VEuPathDB; FungiDB:PCH_Pc21g03390; -.
DR eggNOG; ENOG502QUN5; Eukaryota.
DR HOGENOM; CLU_026505_1_0_1; -.
DR OMA; MLDFMDY; -.
DR OrthoDB; 1463552at2759; -.
DR BioCyc; PCHR:PC21G03390-MON; -.
DR Proteomes; UP000000724; Contig Pc00c21.
DR GO; GO:0032865; C:ERMES complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0000002; P:mitochondrial genome maintenance; IEA:UniProtKB-UniRule.
DR GO; GO:0070096; P:mitochondrial outer membrane translocase complex assembly; IEA:UniProtKB-UniRule.
DR GO; GO:1990456; P:mitochondrion-endoplasmic reticulum membrane tethering; IEA:UniProtKB-UniRule.
DR GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; IEA:UniProtKB-UniRule.
DR HAMAP; MF_03102; Mdm10; 1.
DR InterPro; IPR027539; Mdm10.
DR PANTHER; PTHR28035; PTHR28035; 1.
DR Pfam; PF12519; MDM10; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Transmembrane; Transmembrane beta strand.
FT CHAIN 1..485
FT /note="Mitochondrial distribution and morphology protein
FT 10"
FT /id="PRO_0000384189"
FT REGION 126..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 52397 MW; 9D4F6778B1B3FC1E CRC64;
MLDFMDYIQL SFAEATHWNR DNSYSSLNTT AQSILDFSTP ERLRVHLSSL STPHFATSYT
LGTVGLLDGS VSYLFSTVPF DNLPSGSASI PLRKISPGYR QVQAPATPIE TWGWDSLLDG
VSIPGLTNGS RPEPPIPKDE ESIKESEAKR KATLLHASLH LPPPSTLYAL FLRRISSNMQ
LSLAVCSTQG PPQSKSAPQA SMLTQLSHDT GKYSNEYLFS TDNALFGWRG LWNFGPDPRY
TRDVPPPLSL LSAGAEAYYS PISSLIGMST GLRFTTLPAA TEIPPSSSPS STRTPISTFP
YTLTLTLAPI VGSLSTTYSL RASPNLAFSS RFGFNVYSWE SEMVAGCELW RRTKKSDSSS
DDDLEWARRK MRMHDFGVSL PGSPASPLLE DPARPEGPVS SNAHTEAETS DSVIKLRIDQ
SWNVRLLWEG RVKELLVSAG VGLGPGSFSL SPSVSSASGS GSAQSGGGPG MSYWRGVGVS
VLYSS
