MDM1_DANRE
ID MDM1_DANRE Reviewed; 656 AA.
AC Q5RHU7; A3KNZ6; Q5RHU8;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Nuclear protein MDM1;
GN Name=mdm1; ORFNames=si:ch211-266a5.6;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Microtubule-binding protein that negatively regulates
CC centriole duplication. Binds to and stabilizes microtubules.
CC {ECO:0000250|UniProtKB:Q8TC05}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TC05}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000250|UniProtKB:Q8TC05}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole
CC {ECO:0000250|UniProtKB:Q8TC05}. Note=Localizes to the centriole lumen.
CC {ECO:0000250|UniProtKB:Q8TC05}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5RHU7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5RHU7-2; Sequence=VSP_027553;
CC -!- SIMILARITY: Belongs to the MDM1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI11945.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; BX465210; CAI11945.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BX465210; CAI11946.1; -; Genomic_DNA.
DR EMBL; BC134090; AAI34091.1; -; mRNA.
DR RefSeq; NP_001038285.1; NM_001044820.1. [Q5RHU7-1]
DR AlphaFoldDB; Q5RHU7; -.
DR STRING; 7955.ENSDARP00000116078; -.
DR PaxDb; Q5RHU7; -.
DR Ensembl; ENSDART00000102010; ENSDARP00000092786; ENSDARG00000045675. [Q5RHU7-1]
DR GeneID; 557148; -.
DR KEGG; dre:557148; -.
DR CTD; 56890; -.
DR ZFIN; ZDB-GENE-041210-117; mdm1.
DR eggNOG; ENOG502QVRV; Eukaryota.
DR GeneTree; ENSGT00390000004106; -.
DR HOGENOM; CLU_023835_0_0_1; -.
DR InParanoid; Q5RHU7; -.
DR OMA; KVNTEYR; -.
DR OrthoDB; 350018at2759; -.
DR PhylomeDB; Q5RHU7; -.
DR TreeFam; TF331015; -.
DR PRO; PR:Q5RHU7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000045675; Expressed in testis and 29 other tissues.
DR ExpressionAtlas; Q5RHU7; baseline.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0046600; P:negative regulation of centriole replication; ISS:UniProtKB.
DR InterPro; IPR029136; MDM1.
DR PANTHER; PTHR32078; PTHR32078; 2.
DR Pfam; PF15501; MDM1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton; Microtubule;
KW Nucleus; Reference proteome; Repeat.
FT CHAIN 1..656
FT /note="Nuclear protein MDM1"
FT /id="PRO_0000299064"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 309..337
FT /evidence="ECO:0000255"
FT MOTIF 161..167
FT /note="ST]-E-Y-X(3)-F motif 1; required for efficient
FT microtubule binding and stabilization"
FT /evidence="ECO:0000250|UniProtKB:Q8TC05"
FT MOTIF 204..210
FT /note="ST]-E-Y-X(3)-F motif 2; required for efficient
FT microtubule binding and stabilization"
FT /evidence="ECO:0000250|UniProtKB:Q8TC05"
FT MOTIF 291..297
FT /note="ST]-E-Y-X(3)-F motif 3; required for efficient
FT microtubule binding and stabilization"
FT /evidence="ECO:0000250|UniProtKB:Q8TC05"
FT COMPBIAS 9..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 289..449
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_027553"
FT CONFLICT 42
FT /note="G -> R (in Ref. 2; AAI34091)"
FT /evidence="ECO:0000305"
FT CONFLICT 237
FT /note="S -> T (in Ref. 2; AAI34091)"
FT /evidence="ECO:0000305"
FT CONFLICT 268
FT /note="Q -> K (in Ref. 2; AAI34091)"
FT /evidence="ECO:0000305"
FT CONFLICT 540
FT /note="V -> L (in Ref. 2; AAI34091)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 656 AA; 74293 MW; 431F6961AABFF89C CRC64;
MPVRFKGISE YRSKYKGRTS RSRSDSPHRR MRLAGLRSDQ SGITQEPQFI SKRRVPFYPS
QVSSSFRWEG RDHSQQQLEK SRSPAVSPVL RATSAERQVT PLAPRDPPEG TTAPSQPPQA
EAAQTSTFAV QKQKQALNGI NHALRMKAGL RSEHQRNGLN SEYQRQFMWK TPVAESPLLA
AHQMLYSNNR AIPPFKTNPV IMESEYKRSF KGSPLPRPPR LRRDVEQYEV PEFLTESKTP
EKSKRKKKKK ERPHSRKSSP EQEVAYLQQQ EVKSPHNLKD PSPKVMRKGK TEYRSNFHSP
LQYSYKDGAW LKIKSAKEEV KELRERAEAY KKRAWGTHFS RQHLNQILSD QNWMWEPSSG
TSSSSIESEA CRSTSHIIEA LDLARAGSVR ESSSPGHSAS VVVSRRSSSG EVGLPEEPTL
PVQRKLAWDE EEQLGEREEI VQDRLTDKEG KTRNENGMER NERLNSLESE SLSSAEEGSE
ASVNGGRLPT PKLKTMQTVQ RTHHDRTTPS IDFNLHYIAK AANGSLPRSS PVAGLTTVDV
LPMREDVWSD EEVTDYRSLK PPKPSRKQQS SQRHKANAAP PANRIQGTMR NAEFQHNGNL
GIFRPELFVL PQSDSALSDN DDKMSQISSR SAASCSMASE VLGRAQRRKQ EFWGKS
