ID   MDM32_KLULA             Reviewed;         583 AA.
AC   Q6CUA4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Mitochondrial distribution and morphology protein 32;
DE   Flags: Precursor;
GN   Name=MDM32; OrderedLocusNames=KLLA0C06468g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in the organization of the mitochondrial membranes
CC       and the global structure of the mitochondria. Also required for
CC       mitochondrial distribution and mobility as well as for the maintenance
CC       of mitochondrial DNA nucleoids structures (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MDM31/MDM32 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01336.1; -; Genomic_DNA.
DR   RefSeq; XP_452485.1; XM_452485.1.
DR   AlphaFoldDB; Q6CUA4; -.
DR   STRING; 28985.XP_452485.1; -.
DR   EnsemblFungi; CAH01336; CAH01336; KLLA0_C06468g.
DR   GeneID; 2892562; -.
DR   KEGG; kla:KLLA0_C06468g; -.
DR   eggNOG; ENOG502QQU5; Eukaryota.
DR   HOGENOM; CLU_016236_3_0_1; -.
DR   InParanoid; Q6CUA4; -.
DR   OMA; FAKEMVG; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006873; P:cellular ion homeostasis; IEA:EnsemblFungi.
DR   GO; GO:0000001; P:mitochondrion inheritance; IEA:EnsemblFungi.
DR   InterPro; IPR012571; Mdm31/Mdm32.
DR   PANTHER; PTHR31068; PTHR31068; 1.
DR   Pfam; PF08118; MDM31_MDM32; 2.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..43
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           44..583
FT                   /note="Mitochondrial distribution and morphology protein
FT                   32"
FT                   /id="PRO_0000333679"
FT   TOPO_DOM        44..117
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        139..562
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        563..583
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   583 AA;  67639 MW;  5D83A3A6B03D8DD7 CRC64;
     MFTVLGRVMN RHCALRAHSR IRMPTPMKVS SLLPLPHNLL RTYATEKHDM DELNKSTDYM
     HIQNILLQKE KELSTKHTLL KEATGFYDRF KINTKWFLIR GNRPFSFDEL STLFSWLIIS
     QIIWVILGTT TFVSLVLFTF NTVFAKEMVG KFVGNTLNKY IDSCDVEFQD ALVPEWKKGC
     IRFRSVKVRT VTDGKSDVPS DQLQFDLKFN QVDITLSVRK WMTGHGLIDN LTVLGMHGKV
     VLNDVNENKL VGWFSNPEYH LGAVKVCDSC FTLRDGNQDY RISIYNMDMN RLRFEWCVSD
     FFNANVVTGA INHSLFTIHK RQHKLAYLQD LEKDLSPWKR ITRLRLDRIS VKDLGLDKSS
     SFNWIEEGSV EIIADLMLPN VEDESQDSDE EKNNKYMVMD LKFNFRDLKA KFPESAPTLS
     NGETVISFDE LKPIINYINN RRVIFNSVAT TETIDPDWNR ITPVSIKRQK SYPDTTVIPT
     SVTWPDGEDE VQINKEIIKY HDQPTTNTNN LILKCRIVKN IDELQNVALF RESGVYDVLA
     MELYVDLMKI VEEWEFKKKN SWMRLWGTTL ASQLLIFGLG AMV