MDM36_YEAST
ID MDM36_YEAST Reviewed; 579 AA.
AC Q06820; D6W485;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Mitochondrial distribution and morphology protein 36;
GN Name=MDM36; OrderedLocusNames=YPR083W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=11907266; DOI=10.1091/mbc.01-12-0588;
RA Dimmer K.S., Fritz S., Fuchs F., Messerschmitt M., Weinbach N., Neupert W.,
RA Westermann B.;
RT "Genetic basis of mitochondrial function and morphology in Saccharomyces
RT cerevisiae.";
RL Mol. Biol. Cell 13:847-853(2002).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- FUNCTION: Involved in mitochondrial distribution and morphology.
CC {ECO:0000269|PubMed:11907266}.
CC -!- MISCELLANEOUS: Present with 414 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; U51033; AAB68132.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11501.1; -; Genomic_DNA.
DR PIR; S69069; S69069.
DR RefSeq; NP_015408.1; NM_001184180.1.
DR AlphaFoldDB; Q06820; -.
DR BioGRID; 36254; 201.
DR DIP; DIP-3890N; -.
DR IntAct; Q06820; 1.
DR MINT; Q06820; -.
DR STRING; 4932.YPR083W; -.
DR iPTMnet; Q06820; -.
DR MaxQB; Q06820; -.
DR PaxDb; Q06820; -.
DR PRIDE; Q06820; -.
DR EnsemblFungi; YPR083W_mRNA; YPR083W; YPR083W.
DR GeneID; 856198; -.
DR KEGG; sce:YPR083W; -.
DR SGD; S000006287; MDM36.
DR VEuPathDB; FungiDB:YPR083W; -.
DR eggNOG; ENOG502RNI7; Eukaryota.
DR HOGENOM; CLU_039753_0_0_1; -.
DR InParanoid; Q06820; -.
DR OMA; AKYECLA; -.
DR BioCyc; YEAST:G3O-34227-MON; -.
DR PRO; PR:Q06820; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q06820; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR GO; GO:0000266; P:mitochondrial fission; IMP:SGD.
DR GO; GO:0000001; P:mitochondrion inheritance; IMP:SGD.
DR GO; GO:0007005; P:mitochondrion organization; IMP:SGD.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..579
FT /note="Mitochondrial distribution and morphology protein
FT 36"
FT /id="PRO_0000096332"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 42
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18407956,
FT ECO:0007744|PubMed:19779198"
SQ SEQUENCE 579 AA; 64958 MW; B2C2F608A1F2910E CRC64;
MDENGTVKPG YELKGLNSGN SRSNMDKDPI VSKFHRAGLN DSADEEDTDI NGNRNTSWIT
SMISEEKRKV EGKSMLNDEE DLHLSKATLN KCDALVKILA DIIKLEFVIH QSWYIRSLHK
SVLIQFEVET SGGNKNSAGD SGDDDDDNHN GNLDDSFYKD LSLKCIKKCE KSSLALESLS
RDIDQIRDFI MSNTIEDNRV DRLLQNSMTL LLECWIYSMK RLRRLRMKIA GIFVRSKLLL
IDHELVTIWH FLQEQNEHET VNNENELKLA ETIKSYRAFI KIFIQQLEDS ESGSPSSSLF
EECLHVFLDI ESMYNSLNLN WLLNENKALQ ERLLSPSSTS ENDHTNNLPV IDETKEIEDI
SSFVNSIVDA SMLTHDLTPI NSSDSDNLSN GEIDRLDGRR LSSSTSDMSL MMQRTSLQKQ
LPSLLTAFNN ARRLEQELQN ACKVNDNKHS TKDTDSNIRR NEHAMSSSVS SIISQNSTLA
SPSPPMSSSF ISTAPSQSSS RMSTLPLSPS SSLLESQSQT LKNNMSQWLN QSRSGLNGTK
LIPTNHIGFH SNVLNTLYGI GGGPVSKSYK SNQPSSQNT
