MDN1_DICDI
ID MDN1_DICDI Reviewed; 5900 AA.
AC Q869L3; C7FZZ7;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Midasin;
DE AltName: Full=Dynein-related AAA-ATPase mdn1;
DE AltName: Full=MIDAS-containing protein;
GN Name=mdn1; ORFNames=DDB_G0295765;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. Functions at successive maturation steps
CC to remove ribosomal factors at critical transition points, first
CC driving the exit of early pre-60S particles from the nucleolus and then
CC driving late pre-60S particles from the nucleus.
CC {ECO:0000250|UniProtKB:Q12019}.
CC -!- SUBUNIT: Associates with pre-60S ribosomes in the nucleoplasm.
CC {ECO:0000250|UniProtKB:Q12019}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q12019}. Nucleus, nucleoplasm
CC {ECO:0000250|UniProtKB:Q12019}.
CC -!- SIMILARITY: Belongs to the midasin family. {ECO:0000305}.
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DR EMBL; AAFI02000013; EEU04125.1; -; Genomic_DNA.
DR RefSeq; XP_002649177.1; XM_002649131.1.
DR STRING; 44689.DDB0252730; -.
DR PaxDb; Q869L3; -.
DR PRIDE; Q869L3; -.
DR EnsemblProtists; EEU04125; EEU04125; DDB_G0295765.
DR GeneID; 8620042; -.
DR KEGG; ddi:DDB_G0295765; -.
DR dictyBase; DDB_G0295765; mdn1.
DR eggNOG; KOG1808; Eukaryota.
DR HOGENOM; CLU_000050_0_2_1; -.
DR InParanoid; Q869L3; -.
DR OMA; ELGPPNI; -.
DR PhylomeDB; Q869L3; -.
DR PRO; PR:Q869L3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:2000200; P:regulation of ribosomal subunit export from nucleus; IBA:GO_Central.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 7.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF07728; AAA_5; 8.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF52540; SSF52540; 6.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Chaperone; Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..5900
FT /note="Midasin"
FT /id="PRO_0000363385"
FT DOMAIN 5696..5889
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT REGION 250..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..583
FT /note="AAA-ATPase protomer 1"
FT /evidence="ECO:0000255"
FT REGION 673..1012
FT /note="AAA-ATPase protomer 2"
FT /evidence="ECO:0000255"
FT REGION 796..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1346
FT /note="AAA-ATPase protomer 3"
FT /evidence="ECO:0000255"
FT REGION 1411..1721
FT /note="AAA-ATPase protomer 4"
FT /evidence="ECO:0000255"
FT REGION 1840..2089
FT /note="AAA-ATPase protomer 5"
FT /evidence="ECO:0000255"
FT REGION 2167..2451
FT /note="AAA-ATPase protomer 6"
FT /evidence="ECO:0000255"
FT REGION 2562..4965
FT /note="Linker"
FT /evidence="ECO:0000250|UniProtKB:Q12019"
FT REGION 4932..5598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..824
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4932..4985
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4986..5006
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5007..5054
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5055..5073
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5074..5116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5117..5132
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5142..5158
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5159..5176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5177..5213
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5214..5228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5229..5257
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5335..5374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5386..5401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5410..5449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5450..5466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5472..5488
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5489..5551
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5573..5588
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 302..309
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 689..696
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 1135..1142
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 1438..1445
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 1852..1859
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 2184..2191
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 5900 AA; 678735 MW; 3C6947787C12C771 CRC64;
MYKFKFNIFK AIKALELELT KIKNESSSST IIQDFKSFEQ IFKKKENEFT SQDKLFIVEE
ISNLLMSKPE YPSLISNIFS PLLVDLVSRY IQNGKKEERW LGLVQSCFRL LSFNKSLFSS
LWDWTPLFSL LEIKSQRITW YVIKSMSMVL NVPDHQITQI KPLFKQYHNQ IIQIESELLN
LESSKLFLNN NNNNNNKKEN INNNQEEEKE DEELINKYPN IFIQKQDLHK SIVDVCGILL
FKKFEQIGHG SSVKSKKGGE QQQEGEGEDE QVQKLVYTNT VSQNLNSLAI AVGLGKPILI
EGVTGSGKTT MIEELSRITG NDNIIRIHLG DQTDSKVLLG TYITSDTPGE FKWQAGALTQ
AVQEGRWILI EDIDLAPIEV LSVLIPLLEN RTLFIPGRGE VIEASNGFQL FATQTLFGSH
SRDQNANILS HLWTRVVIEA LSPTEMKQVL LTLFPQLTVM ISKFIETFNL LLRVISNQSI
SISPTDEVAG IANIANTANV NNINNNNNTD NNNNNNSNEK FIIPSSRFIS SRDLIKWIRR
CNQRLHLTNV SQQIITSTMQ EIVFVEALDC FCSMISKKNL RKQLTQVIGR VWELTGDRIN
YYVELYKPSI IITQESVSTG RAKLKSLEKS DSIQISNGKK HTRFTTEQSQ QDSGVTKHGN
VFAHTMNSLR LMEKISISIQ FNEPILLVGE TGTGKTSVVQ YIADQLNQKL VVLNLNQQSD
SSDLIGGFKP VEMRLLCLPL KNRFDSMFKK TFSESNNTDF LEKIDKAFIS KNWKQFIALL
NKAIKLVENK VLKDDQTTTN NTKENNNNNN NNNNNNNNNN NNKKRTIRSE VKEKWIKLSN
DIKKLTIQFE KSKNNFAFSF VEGSLVNCIR KGYWVLLDEM NLATSETLES LSGLFDGGSI
TLTEKGEVEP VERHPNFKVF ACMNPPTDIG KKDLPPGIRN RFTEYYVDDL DNRGDLCLVV
KTVLSNLVPN PPIEDIVEFY LKTKQDAQNK MLDGSNQKPI FSLRTLSRAL NYTKHVTKSF
GFQRALFEGI SMSFLTQLNK SSYPMMEQLI KQYIKKGEVK LYNQPLNRPP PTSTTNNNNN
NAEESYVKIE QFWIECGNEK PIIPTHYILT PSIKSNLSNI ARVLVSRKHP ILLQGPTSSG
KTSMVEYLAI RTGHRFIRIN NHEHTDLQEY LGQYISDDKG KLVFQEGILV EAVRKGYWVV
LDELNLAPSE VLEALNRLLD DNRELFIPET QEVVRPHPHF MLFATQNPPG LYGGRKVLSR
AFRNRFLELH VDDIPEDELE EILCKRCALP PSYCKKLVLI MKELQLNRQG SNQVFAGKHG
AITFRDLFRW AERQPSSYEE LGIAGYQLLA ERLRKDEEKL IIKQVIEKHL KIKLDIESIY
SCDDKPEFLK LLQLLSENDS ELSKSNHLEK IVWTRSMKRL FSLVGKCLEH KEPILLVGET
GCSKTTICQL YSILNKQKLH ILNCHQHTET ADFIGGLRPV RGRDQVLSKL YSLVKQYFNQ
LSQLNLYKLE QENNNIDELP IKEIMERLIV ESWKQVSNSS LLTEQLKQLA IEIDKTYSSY
CSLFNWVDGP LVEAMKQGDY FLIDEISLAE DAVLERLNSV LEPSRLLVLA EKGGVEIEEL
RGHKEFRILA TMNPGGDFGK KELSPAMRNR FTEIWVPAIS SHQDLLQIIE ERFTSPQLKG
KGSLMLNFIE YLLMIQKNKR VISLRDILSW ISFMNLCMDK QLLSPNESYI HGACLVLLDG
FGMGSNSSSE SEGLKLREAC LIRLIDQIES QDEKLKLQTE LLSTSSSSSS LSSSIANIIK
EENRFGIHPF YIPVRESNVP KIQFSLSAPT TSKNAQRVLR GMQLPRAILV EGSPGVGKTS
LITAIANASG NQIVRINLSE QTDIMDLLGS DLPVEGGTGG QFEWRDGVFL EALRNGSWVL
LDELNLASQT VLEGLNSCLD HRSEVYIPEL GKTFACHPNF RVFACQNPLH QGGGRKGLPK
SFLNRFTQVF IDQLNQQDLL FISTAMYPTI PSKTIERMIE FNHQMFKESM IEHKFARKGA
PWEFNLRDTF RWCDLIVKDP TSISNPARFI DLIYLQRMRT LQDREHVLTI FKRVFTTSGD
ENDQSIDMMP TICNYDKQPH YSISPEYLQI GSSILPRVQN GGASSFDSSV LDNSSNIQLL
QRLLNPLENI MKCIEMNWMS ILIGPTSTSK TSSIRLLAQL TGNTLYEFSM NSSVDTTEIL
GGFEQIDLVR YQKRIISSVS SLITIVSSHI MTYFNSNDDN LMKTCISSIQ DIHQVWNLFK
KQTQQTQQQI QQDGATIGSG GVGLITIEQL DLLSTIVDAL EKLSIQFNLD NNQEHLNRIQ
DVRQQIQRIK SIEKESVTGC FEWIDGLLIK ALETGAWILI DNVNFCNPTV LDRLNPLLEQ
DGVLMLNERG MVDGQVKVVK PHPNFRIFLT MDDKKGEISR AMRNRGIEIY MAADQLSLME
TPSNNFDNQQ LLTALGIPLE SLTRTMIDFH NQIFTQLSST IENPCTLSQL LYWGKLILDQ
LQRGFSLLNS IRNSMEQIYI RPRRHLTQRQ LVTNIFNSIF NESAIKSILC EDQTVLGIYP
HFIKGKDYVT DSISTTMKMN YQFFEYYLKR LMNSLSSSSS SSSQQQQQDE SNYKISAKFL
IENINSSQYE NYVLYLNSLK DQNEKDSPIN QLLTTLISCM KQLFNHTCYK DFEKRLEQLL
SMINLSFIDS KQLLIYQGHQ WKNNDSLFLL IKEKVDNYIT KEAGGSESMI PIKDLFNQVL
LNDMEIIKSL LSLFIQSSKQ EKEYNKFLKQ VQQGNASQQL SVKSIKSIPV ILLSLAYTKK
MMSKDLLPHQ DIISMIYRLF KSLDEQIDQW LIQLSSSEQQ QSTFSTIQII NQLILLKNNF
WNSTFNLPSN QFNLGEFIIR WRWIYKEINK LTTLTSKSES PLLINTGLQV LIDKISSGLN
QYNNDNSNNR LWKVGGYPMV MKSNHLVQLD SQFLSILEKV QYNFNKNESP IKHSSYAIDE
DWKKTLIEAI STLYWANYQL NSDNQNQEQQ QQELDRVSEF LTNLELVPQT LSDKLKQLIE
KQKQFELNST FNPVSTNFDN SDISNDSMIS DATSIHFDPL SIKHQVISIS PLIDHSLHLK
ETFVISELVK LLMLQHMDIE NGKMNQSIIT IFESIIDELK YIVNKYKSST IPRSLYHLAF
YQKLIWMIDN YLEKVTTNQE KDEQGQEQEQ ASIGIIELQS VIHSILYVYN SSQWNNAFND
ISHVGKYSLP QYKYRLSKND AAASLDNGSS KVNIYDSIRF GYGPPRLFQN IQTVFSFYLT
CDWEYVSIAD VPVKIEQLNQ IIQHLTSADG SSNVSNIESF EYQIKQTIAL LLSTITSFYK
SFNNDEHKKH QLLSNVALIG EHLLSSSSSL EILDIGFDEL IENIKELIIQ SNDKSFNEKS
KQLLLPCLDI LLCLDDKVLY KDELKLQSTF GRLQLLLNTF RLIMFVPSGS IDPTQKYDVI
LQYSKEHSKQ LQDEIEIRTI IEKQYTGKDG TSLVIDELVQ KKQSIDQKLA LDSKKITLRP
IPSQFEELYR DVSQFSNHFS NIEKIIDLIS KLDLSQVKNE FNLEVESEGG DNQQQQENNT
SANSSYNQMI LSTEQMWQEK ANHFIQSCEK KFYSRYRDII VPIITAVYQM KSGLRMMSVS
FKQKVQDNKL GGNQGITKQI QKVLLSLTQF PRINSVDINS KITTTSTTTT ATTTTNTTSN
NILLDKLTLD SIKDMMKFNQ RTNQDNCNGG LQNFKVIGLL LRSSLCQIYS QLSNSNYLDV
DNLEAIDSIF RIFVQEWRFQ EEEKRKKEEL ENQEFKYKVQ THKMETKEEK DEKVFLTSFP
NFYKDFEDLE VANVVENQID DDNDEENKDK ENNESNVLTS EDGSMFFKSS INNEEILQLC
SIHRDIFKHL DGIPIPKEQQ QWTLSDRDRS ELFQLFYSSS YLLMKILNQR SGDMEFDQLS
LGSHILSASN LKETLSIRPP SLITYSKLDE KFRFLKTSSY LYKKSKGIND DDGDNQVVDV
IHQKKTYNIY RDSNISEIGI IREPLISFRK RVFELLVEYP EQANLTLMVK LIDRLMTYPA
TDPLAKILTG LELLLRKSLE WESFASKAVS IQNHLNEISS LIVRWRKLEI ESWPSIFQSQ
EKEAEVKALK SWFILYDLIN DEPSSPELED ENLSKNFHTL QQYLYSSSLG DFLTRIELLK
SFYKQLNSTI KLIGTSKNTN YKQKLSDIIY NIFKYFENFI SRFEDRLAKS IKPIEDKALE
FIRLSRWDDN RLLTQYERLK QHIEVSHRNL AKVTIKYKNV LAQPLHDIFT QIENELDIPP
LVLHSGAATI LEDKLKKNQK LNKKQIQKKS LAIENFNDWL SFSPSNYSID RKSIDSISKP
IEIESPLLKK LFQIENEKLA QNKLSLLSKR MIQICKENLL ESDSWKVVRD GVDIINDLSI
EIIDRLKELS SDEKIKRQEK EFALKELMSK FHEMGLSYHI NRYPQEQLQI SYLFNVRHLP
TISDNQGYLP TSFSKITADN GAKLLDQADQ YYYRIVSRVH RLRQLSIEYN SDLSSKHVQR
INGYVEHFLS IIINQRNNLI DSINSWNHLT LFTELFTNIS GSGGSNSEID EQIFNNHNML
SKWFEIQRES INQFNQAIKE ILLLCRKTTS AVSGGMISTI IPEICSIQII IESIKSEIDK
HQSKLRNLFS FLNNQYPMMT WSTINLIISI FTKFKEIKEK LNQLLLSKLS NINYIKSPIQ
ILINNIDSLI NKFNSEYEEL VGNEINDNDI ENQNNIKEFT NQFGILIDQI LISIQDLKIQ
SNQIIAYNKE QEELDQELEK VREYTIEDGS ISKLSEFIDH QVQSLRLSKL LEQFVKLHNI
IVDGGGSVST LSIYRQMIKQ MGPLLAQFML IVNQSIVDSL SYHKTCCKLE YISTGVFIQL
YSKGFCKPAD GGDDGEGGEG GRSNFEDDVE GTGMGEGKGK KDVSDQLEDQ GQIEDTNTQK
KEEKDEDEDE EKEEKDEDEG FDMQDDFEGE MHDIKKDENK DEDKKDDPNN EKENDKEMGD
LEKPEDNVVD EKLWDEQDVQ DEEEQDEEGK GDETNSEEMM AKQDGKDDND DDKKDDDKKD
DKKKKKEENG KPDENEEGEE GKDDEEEDGK DDNKNADDGA SDEDDFGQEE NEDDVINQEQ
EKEENHGDPR GDDQMEIPED LELEDPDEGK EDDEQQDGGD DFKDPLDEMD GDDVSKEEEK
KKELDGDEKE ESDQDGDEEK EDEEKEDGDE DEDKEDKENQ PIDPSNVDSI NPEGDEPEKE
QPEEDQTSLT TNEQQDETPK DSEQPLGVKD KTGSKSNVSN TDEEMKDESN QDNADDDSGM
TQPTPSENDT GALKNLKSQP PPQSSAQQPP KKQKQVDPNP YRSMGDANKE WKKRLNLKQE
QEEEEEEQSS EPKEKAPKQD PNAKENENQD YEFIKDDEKL DKDEETDQAL AAATDTQLQD
IPQNKAQDDQ AEQEEDQMDI DEEDDMDVDH KQEVEHQDDS KQQLDENKKI SMSKLKQDQL
KQQKEKEKEK LEKDQQDGQD DELDGLNQKE QFTKEQLENL TNLDKEKAVL DDGDDQEMEQ
DGDQDDEESV EEKKLTREDL DRMRQELEQY KIENSSNPEI GTELWKKYEQ LTNDLSQDLC
EQLRLILEPT LATKLQGDYK SGKRINMKKV IPYIASQFKK DKIWLRRTKP NKRQYQVLLA
IDDTESMAAY HSGGFALEAM TMISRAMSRL EVGQLGIVRF GEDVQLVHSF DQVFSDQTGP
EIITQFKFQQ TKTNMVNFLS KTLQIMDMNK QSSSGEPAMQ LVFIVSDGWS LRDPETTKKY
LREASIKNVF IVFIVIDNPV NNNSILDFES ISFNNGKIQR TNYMSEFPFM YYVILRSLNN
IPSILSDTLR QWFDLTKSTQ
