ID   MDPA_EMENI              Reviewed;         479 AA.
AC   C8VQ72; Q5BH35;
DT   07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Monodictyphenone cluster transcriptional coactivator mdpA {ECO:0000303|PubMed:20139316};
DE   AltName: Full=Monodictyphenone synthesis protein A {ECO:0000303|PubMed:20139316};
GN   Name=mdpA {ECO:0000303|PubMed:20139316}; ORFNames=ANIA_10021;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=20139316; DOI=10.1128/aem.02187-09;
RA   Chiang Y.M., Szewczyk E., Davidson A.D., Entwistle R., Keller N.P.,
RA   Wang C.C., Oakley B.R.;
RT   "Characterization of the Aspergillus nidulans monodictyphenone gene
RT   cluster.";
RL   Appl. Environ. Microbiol. 76:2067-2074(2010).
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=21351751; DOI=10.1021/ja1096682;
RA   Sanchez J.F., Entwistle R., Hung J.H., Yaegashi J., Jain S., Chiang Y.M.,
RA   Wang C.C., Oakley B.R.;
RT   "Genome-based deletion analysis reveals the prenyl xanthone biosynthesis
RT   pathway in Aspergillus nidulans.";
RL   J. Am. Chem. Soc. 133:4010-4017(2011).
CC   -!- FUNCTION: Transcriptional coactivator; part of the gene cluster that
CC       mediates the biosynthesis of monodictyphenone, a prenyl xanthone
CC       derivative (PubMed:20139316, PubMed:21351751). With mdpE, coregulates
CC       the production of monodictyphenone (PubMed:20139316, PubMed:21351751).
CC       {ECO:0000269|PubMed:20139316, ECO:0000269|PubMed:21351751}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Impairs the production of monodictyphenone and of
CC       any of the intermediates of the pathway (PubMed:20139316,
CC       PubMed:21351751). {ECO:0000269|PubMed:20139316,
CC       ECO:0000269|PubMed:21351751}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA66018.1; Type=Erroneous gene model prediction; Note=The predicted gene AN0145 has been split into 2 genes: ANIA_10021 and ANIA_10049.; Evidence={ECO:0000305};
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DR   EMBL; BN001308; CBF90109.1; -; Genomic_DNA.
DR   EMBL; AACD01000005; EAA66018.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; C8VQ72; -.
DR   SMR; C8VQ72; -.
DR   PRIDE; C8VQ72; -.
DR   EnsemblFungi; CBF90109; CBF90109; ANIA_10021.
DR   EnsemblFungi; EAA66018; EAA66018; AN0145.2.
DR   eggNOG; KOG3178; Eukaryota.
DR   HOGENOM; CLU_005533_11_0_1; -.
DR   InParanoid; C8VQ72; -.
DR   OMA; LLACIQW; -.
DR   OrthoDB; 817726at2759; -.
DR   Proteomes; UP000000560; Chromosome VIII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   4: Predicted;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..479
FT                   /note="Monodictyphenone cluster transcriptional coactivator
FT                   mdpA"
FT                   /id="PRO_0000437060"
FT   DOMAIN          77..147
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   DNA_BIND        107..126
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   REGION          281..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          314..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   479 AA;  51980 MW;  F8D83D97DD52254C CRC64;
     MMSSLSDLET HASELTSAVK TIISQCPRQN AASRSRTQPL ITSSASKEAH RAQQSILSTI
     SGLQKLLTSP TDFLHHLAVQ NQLLACLQWL GEFQVLACIP LTGTVPIKDV AELAGVPETH
     LSRIIRMTAT AGFLDEPDPG QVAHSALSAP FVTKPSYLDA VMFLAGTIAP SALQMPTATQ
     RFGASLRPNE TAYNLALNNP ATFASTSEQR PKLQRQWPAF LQYGTSDTDD RVTDLLSRLD
     HFRRGSISVV EVSARSLDRA TTLANLYPSI NITVQIASPA GPTAWSPAHP NPIRPPTPGG
     SHKHDDLRAL TASTASTTPA SSHNHTHTHT TNSIPQASNI TIQHRLPTAP QPITSANLYI
     LHLPSPSPTV PFASLATHIL AELRSHLDIL RSNPSATLIL TPRPLPEPSA VHSEVEASAR
     LRDLTLMQLA NEREIELAEW INLLSNVSDS MGRLVVVNKI QSRESTVVLL EIRYQAYNR