ID   MDR1_ENTHI              Reviewed;         114 AA.
AC   P16875;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Multidrug resistance protein 1;
DE   AltName: Full=P-glycoprotein;
DE   Flags: Fragment;
GN   Name=MDR1;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1970121; DOI=10.1016/0166-6851(90)90031-g;
RA   Samuelson J., Ayala P., Orozco E., Wirth D.;
RT   "Emetine-resistant mutants of Entamoeba histolytica overexpress mRNAs for
RT   multidrug resistance.";
RL   Mol. Biochem. Parasitol. 38:281-290(1990).
CC   -!- FUNCTION: Energy-dependent efflux pump responsible for decreased drug
CC       accumulation in multidrug-resistant cells.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC       Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M29058; AAA29107.1; -; Genomic_DNA.
DR   PIR; A44970; A44970.
DR   AlphaFoldDB; P16875; -.
DR   SMR; P16875; -.
DR   STRING; 5759.rna_EHI_175450-1; -.
DR   VEuPathDB; AmoebaDB:EHI5A_262080; -.
DR   VEuPathDB; AmoebaDB:EHI_125030; -.
DR   VEuPathDB; AmoebaDB:KM1_243070; -.
DR   eggNOG; KOG0055; Eukaryota.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039421; Type_1_exporter.
DR   PANTHER; PTHR24221; PTHR24221; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Membrane; Nucleotide-binding; Repeat; Transmembrane;
KW   Transport.
FT   CHAIN           <1..>114
FT                   /note="Multidrug resistance protein 1"
FT                   /id="PRO_0000093372"
FT   NON_TER         1
FT   NON_TER         114
SQ   SEQUENCE   114 AA;  12490 MW;  58AC57022B12A0C6 CRC64;
     SGCGKSTTIQ LIQRNYEPNG GRVTLDGKDI RELNIKWLRN QIGLVGQEPV LFAGTIRENI
     MLGAKEGETL SKDEMIECAK MANAHEFVSK LAEGYDTLIG EKGALLSGGQ RQRI