MDR1_HUMAN
ID MDR1_HUMAN Reviewed; 1280 AA.
AC P08183; A8K294; B5AK60; Q12755; Q14812;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 239.
DE RecName: Full=ATP-dependent translocase ABCB1 {ECO:0000305};
DE AltName: Full=ATP-binding cassette sub-family B member 1 {ECO:0000305};
DE AltName: Full=Multidrug resistance protein 1;
DE EC=7.6.2.2;
DE AltName: Full=P-glycoprotein 1;
DE AltName: Full=Phospholipid transporter ABCB1 {ECO:0000305};
DE EC=7.6.2.1 {ECO:0000269|PubMed:8898203};
DE AltName: CD_antigen=CD243;
GN Name=ABCB1 {ECO:0000312|HGNC:HGNC:40}; Synonyms=MDR1, PGY1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-185 AND ALA-893, AND
RP POLYMORPHISM.
RX PubMed=2876781; DOI=10.1016/0092-8674(86)90595-7;
RA Chen C.-J., Chin J.E., Ueda K., Clark D.P., Pastan I., Gottesman M.M.,
RA Roninson I.B.;
RT "Internal duplication and homology with bacterial transport proteins in the
RT mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.";
RL Cell 47:381-389(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALA-893.
RX PubMed=1967175; DOI=10.1016/s0021-9258(19)40260-3;
RA Chen C.-J., Clark D.P., Ueda K., Pastan I., Gottesman M.M., Roninson I.B.;
RT "Genomic organization of the human multidrug resistance (MDR1) gene and
RT origin of P-glycoproteins.";
RL J. Biol. Chem. 265:506-514(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-185 AND ALA-893,
RP POLYMORPHISM, AND FUNCTION.
RX PubMed=9038218; DOI=10.1074/jbc.272.9.5974;
RA Chen G., Duran G.E., Steger K.A., Lacayo N.J., Jaffrezou J.P., Dumontet C.,
RA Sikic B.I.;
RT "Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein,
RT altered phenotype, and resistance to cyclosporins.";
RL J. Biol. Chem. 272:5974-5982(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Jiang Y., Sun Q., Xie Z., Liu F., Xu W., Wang Y.;
RT "Cloning of P-glycoprotein cDNA sequence from breast cancer MCF7 cell
RT line.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LEU-17; ASP-21; ASN-400;
RP LYS-566; CYS-593; VAL-836; ALA-893; ALA-1051; THR-1141 AND ILE-1251.
RG NIEHS SNPs program;
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ASP-21.
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 178-215 AND 800-856.
RX PubMed=1972623; DOI=10.1016/0006-291x(90)90401-8;
RA Gekeler V., Weger S., Probst H.;
RT "mdr1/P-glycoprotein gene segments analyzed from various human leukemic
RT cell lines exhibiting different multidrug resistance profiles.";
RL Biochem. Biophys. Res. Commun. 169:796-802(1990).
RN [9]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-23 (ISOFORM 1/2).
RX PubMed=2568832; DOI=10.1016/0006-291x(89)91985-2;
RA Kioka N., Tsubota J., Kakehi Y., Komano T., Gottesman M.M., Pastan I.,
RA Ueda K.;
RT "P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein
RT carries Gly185 with an altered pattern of multidrug resistance.";
RL Biochem. Biophys. Res. Commun. 162:224-231(1989).
RN [10]
RP SUBCELLULAR LOCATION, CATALYTIC ACTIVITY, FUNCTION, AND ACTIVITY
RP REGULATION.
RX PubMed=8898203; DOI=10.1016/s0092-8674(00)81370-7;
RA van Helvoort A., Smith A.J., Sprong H., Fritzsche I., Schinkel A.H.,
RA Borst P., van Meer G.;
RT "MDR1 P-glycoprotein is a lipid translocase of broad specificity, while
RT MDR3 P-glycoprotein specifically translocates phosphatidylcholine.";
RL Cell 87:507-517(1996).
RN [11]
RP REVIEW.
RX PubMed=11258197; DOI=10.1517/14622416.2.1.51;
RA Kerb R., Hoffmeyer S., Brinkmann U.;
RT "ABC drug transporters: hereditary polymorphisms and pharmacological impact
RT in MDR1, MRP1 and MRP2.";
RL Pharmacogenomics 2:51-64(2001).
RN [12]
RP INTERACTION WITH PSMB5.
RX PubMed=15488952; DOI=10.1016/j.molimm.2004.07.005;
RA Begley G.S., Horvath A.R., Taylor J.C., Higgins C.F.;
RT "Cytoplasmic domains of the transporter associated with antigen processing
RT and P-glycoprotein interact with subunits of the proteasome.";
RL Mol. Immunol. 42:137-141(2005).
RN [13]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [14]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [15]
RP INTERACTION WITH PPP2R3C.
RX PubMed=24333728; DOI=10.1016/j.canlet.2013.12.007;
RA Katayama K., Yamaguchi M., Noguchi K., Sugimoto Y.;
RT "Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-
RT glycoprotein/ABCB1 and down-regulates the expression and function.";
RL Cancer Lett. 345:124-131(2014).
RN [16]
RP VARIANT VAL-185, POLYMORPHISM, AND FUNCTION.
RX PubMed=2897240; DOI=10.1016/0092-8674(88)90568-5;
RA Choi K.H., Chen C.-J., Kriegler M., Roninson I.B.;
RT "An altered pattern of cross-resistance in multidrug-resistant human cells
RT results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.";
RL Cell 53:519-529(1988).
RN [17]
RP VARIANTS ALA-893 AND THR-999.
RX PubMed=9473242;
RA Mickley L.A., Lee J.-S., Weng Z., Zhan Z., Alvarez M., Wilson W.,
RA Bates S.E., Fojo T.;
RT "Genetic polymorphism in MDR-1: a tool for examining allelic expression in
RT normal cells, unselected and drug-selected cell lines, and human tumors.";
RL Blood 91:1749-1756(1998).
RN [18]
RP VARIANT ASP-21.
RX PubMed=10790226;
RX DOI=10.1002/(sici)1098-1004(200005)15:5<486::aid-humu26>3.0.co;2-p;
RA Decleves X., Chevillard S., Charpentier C., Vielh P., Laplanche J.-L.;
RT "A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding
RT the P-glycoprotein.";
RL Hum. Mutat. 15:486-486(2000).
RN [19]
RP VARIANTS ASP-21; LEU-103 AND ASN-400.
RX PubMed=10716719; DOI=10.1073/pnas.97.7.3473;
RA Hoffmeyer S., Burk O., von Richter O., Arnold H.P., Brockmoeller J.,
RA Johne A., Cascorbi I., Gerloff T., Roots I., Eichelbaum M., Brinkmann U.;
RT "Functional polymorphisms of the human multidrug-resistance gene: multiple
RT sequence variations and correlation of one allele with P-glycoprotein
RT expression and activity in vivo.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:3473-3478(2000).
RN [20]
RP VARIANTS ASP-21; ASN-400; ALA-893; THR-893 AND PRO-1107.
RX PubMed=11240981; DOI=10.1067/mcp.2001.114164;
RA Cascorbi I., Gerloff T., Johne A., Meisel C., Hoffmeyer S., Schwab M.,
RA Schaeffeler E., Eichelbaum M., Brinkmann U., Roots I.;
RT "Frequency of single nucleotide polymorphisms in the P-glycoprotein drug
RT transporter MDR1 gene in white subjects.";
RL Clin. Pharmacol. Ther. 69:169-174(2001).
RN [21]
RP VARIANT LYS-108.
RX PubMed=15618700; DOI=10.2133/dmpk.17.479;
RA Honda T., Dan Y., Koyabu N., Ieiri I., Otsubo K., Higuchi S., Ohtani H.,
RA Sawada J.;
RT "Polymorphism of MDR1 gene in healthy Japanese subjects: a novel SNP with
RT an amino acid substitution (Glu108Lys).";
RL Drug Metab. Pharmacokinet. 17:479-481(2002).
RN [22]
RP VARIANT ILE-1251.
RX PubMed=15618713; DOI=10.2133/dmpk.17.566;
RA Itoda M., Saito Y., Komamura K., Ueno K., Kamakura S., Ozawa S., Sawada J.;
RT "Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese
RT patients with ventricular tachycardia who were administered amiodarone.";
RL Drug Metab. Pharmacokinet. 17:566-571(2002).
RN [23]
RP VARIANTS ALA-893 AND THR-893.
RX PubMed=11829140; DOI=10.1007/s10038-002-8653-6;
RA Saito S., Iida A., Sekine A., Miura Y., Ogawa C., Kawauchi S., Higuchi S.,
RA Nakamura Y.;
RT "Three hundred twenty-six genetic variations in genes encoding nine members
RT of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese
RT population.";
RL J. Hum. Genet. 47:38-50(2002).
RN [24]
RP VARIANTS ALA-893 AND THR-893, AND ASSOCIATION WITH SUSCEPTIBILITY TO IBD13.
RX PubMed=14610718; DOI=10.1086/379927;
RA Brant S.R., Panhuysen C.I.M., Nicolae D., Reddy D.M., Bonen D.K.,
RA Karaliukas R., Zhang L., Swanson E., Datta L.W., Moran T., Ravenhill G.,
RA Duerr R.H., Achkar J.-P., Karban A.S., Cho J.H.;
RT "MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.";
RL Am. J. Hum. Genet. 73:1282-1292(2003).
RN [25]
RP ERRATUM OF PUBMED:14610718.
RA Brant S.R., Panhuysen C.I.M., Nicolae D., Reddy D.M., Bonen D.K.,
RA Karaliukas R., Zhang L., Swanson E., Datta L.W., Moran T., Ravenhill G.,
RA Duerr R.H., Achkar J.-P., Karban A.S., Cho J.H.;
RL Am. J. Hum. Genet. 74:1080-1080(2004).
RN [26]
RP VARIANT [LARGE SCALE ANALYSIS] ASN-887.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Translocates drugs and phospholipids across the membrane
CC (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of
CC phospholipids from the cytoplasmic to the exoplasmic leaflet of the
CC apical membrane. Participates mainly to the flop of
CC phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides
CC and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump
CC responsible for decreased drug accumulation in multidrug-resistant
CC cells (PubMed:2897240, PubMed:9038218). {ECO:0000269|PubMed:2897240,
CC ECO:0000269|PubMed:8898203, ECO:0000269|PubMed:9038218}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate +
CC xenobioticSide 2.; EC=7.6.2.2; Evidence={ECO:0000269|PubMed:9038218};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate +
CC phospholipidSide 2.; EC=7.6.2.1;
CC Evidence={ECO:0000269|PubMed:8898203};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O
CC = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) +
CC phosphate; Xref=Rhea:RHEA:36439, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:64612, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000269|PubMed:8898203};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a
CC 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate;
CC Xref=Rhea:RHEA:38583, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57643,
CC ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:8898203};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP +
CC H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP +
CC H(+) + phosphate; Xref=Rhea:RHEA:38943, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:22801, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000269|PubMed:8898203};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP +
CC H(+) + phosphate; Xref=Rhea:RHEA:38903, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000269|PubMed:8898203};
CC -!- ACTIVITY REGULATION: Translocase activity is inhibited by verapamil and
CC is sensitive to energy depletion. {ECO:0000269|PubMed:8898203}.
CC -!- SUBUNIT: Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and
CC PPP2R3C; leading to the dephosphorylation of ABCB1.
CC {ECO:0000269|PubMed:15488952, ECO:0000269|PubMed:24333728}.
CC -!- INTERACTION:
CC P08183; Q86VI4: LAPTM4B; NbExp=2; IntAct=EBI-1057359, EBI-3267258;
CC P08183; Q99496: RNF2; NbExp=2; IntAct=EBI-1057359, EBI-722416;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Apical cell membrane
CC {ECO:0000269|PubMed:8898203}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P08183-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P08183-2; Sequence=VSP_055769;
CC -!- TISSUE SPECIFICITY: Expressed in liver, kidney, small intestine and
CC brain.
CC -!- POLYMORPHISM: Genetic variation in ABCB1 may play a role in patients
CC who do not respond to drug treatment. {ECO:0000269|PubMed:2876781,
CC ECO:0000269|PubMed:2897240, ECO:0000269|PubMed:9038218}.
CC -!- DISEASE: Inflammatory bowel disease 13 (IBD13) [MIM:612244]: A chronic,
CC relapsing inflammation of the gastrointestinal tract with a complex
CC etiology. It is subdivided into Crohn disease and ulcerative colitis
CC phenotypes. Crohn disease may affect any part of the gastrointestinal
CC tract from the mouth to the anus, but most frequently it involves the
CC terminal ileum and colon. Bowel inflammation is transmural and
CC discontinuous; it may contain granulomas or be associated with
CC intestinal or perianal fistulas. In contrast, in ulcerative colitis,
CC the inflammation is continuous and limited to rectal and colonic
CC mucosal layers; fistulas and granulomas are not observed. Both diseases
CC include extraintestinal inflammation of the skin, eyes, or joints.
CC Note=Disease susceptibility is associated with variants affecting the
CC gene represented in this entry.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM49149.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/PGY1ID105.html";
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/abcb1/";
CC -!- WEB RESOURCE: Name=Wikipedia; Note=P-glycoprotein entry;
CC URL="https://en.wikipedia.org/wiki/P-glycoprotein";
CC -!- WEB RESOURCE: Name=ABCMdb; Note=Database for mutations in ABC proteins;
CC URL="http://abcm2.hegelab.org/search";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M14758; AAA59575.1; -; mRNA.
DR EMBL; M29447; AAA59576.1; -; Genomic_DNA.
DR EMBL; M29424; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29425; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29426; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29427; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29428; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29429; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29430; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29431; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29432; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29433; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29434; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29435; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29436; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29437; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29438; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29439; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29440; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29441; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29442; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29443; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29444; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29445; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; M29446; AAA59576.1; JOINED; Genomic_DNA.
DR EMBL; AF016535; AAB69423.1; -; mRNA.
DR EMBL; EU854148; ACF94688.1; -; mRNA.
DR EMBL; AY910577; AAW82430.1; -; Genomic_DNA.
DR EMBL; AK290159; BAF82848.1; -; mRNA.
DR EMBL; AC002457; AAM49149.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC005068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M37724; AAA88047.1; -; Genomic_DNA.
DR EMBL; M37725; AAA88048.1; -; Genomic_DNA.
DR EMBL; X58723; CAA41558.1; -; Genomic_DNA.
DR CCDS; CCDS5608.1; -. [P08183-1]
DR PIR; A34914; DVHU1.
DR RefSeq; NP_000918.2; NM_000927.4. [P08183-1]
DR PDB; 6C0V; EM; 3.40 A; A=1-1280.
DR PDB; 6FN1; EM; 3.58 A; A=32-1279.
DR PDB; 6FN4; EM; 4.14 A; A=1-1279.
DR PDB; 6QEX; EM; 3.60 A; A=1-1280.
DR PDB; 7A65; EM; 3.90 A; A=1-1280.
DR PDB; 7A69; EM; 3.20 A; A=1-1280.
DR PDB; 7A6C; EM; 3.60 A; A=1-1280.
DR PDB; 7A6E; EM; 3.60 A; A=1-1280.
DR PDB; 7A6F; EM; 3.50 A; A=1-1280.
DR PDB; 7O9W; EM; 3.50 A; A=1-1280.
DR PDBsum; 6C0V; -.
DR PDBsum; 6FN1; -.
DR PDBsum; 6FN4; -.
DR PDBsum; 6QEX; -.
DR PDBsum; 7A65; -.
DR PDBsum; 7A69; -.
DR PDBsum; 7A6C; -.
DR PDBsum; 7A6E; -.
DR PDBsum; 7A6F; -.
DR PDBsum; 7O9W; -.
DR AlphaFoldDB; P08183; -.
DR SMR; P08183; -.
DR BioGRID; 111262; 41.
DR CORUM; P08183; -.
DR IntAct; P08183; 10.
DR MINT; P08183; -.
DR STRING; 9606.ENSP00000478255; -.
DR BindingDB; P08183; -.
DR ChEMBL; CHEMBL4302; -.
DR DrugBank; DB12001; Abemaciclib.
DR DrugBank; DB01193; Acebutolol.
DR DrugBank; DB01418; Acenocoumarol.
DR DrugBank; DB00316; Acetaminophen.
DR DrugBank; DB00945; Acetylsalicylic acid.
DR DrugBank; DB08916; Afatinib.
DR DrugBank; DB00518; Albendazole.
DR DrugBank; DB04630; Aldosterone.
DR DrugBank; DB11363; Alectinib.
DR DrugBank; DB00802; Alfentanil.
DR DrugBank; DB00346; Alfuzosin.
DR DrugBank; DB09026; Aliskiren.
DR DrugBank; DB00523; Alitretinoin.
DR DrugBank; DB12015; Alpelisib.
DR DrugBank; DB14003; alpha-Tocopherol acetate.
DR DrugBank; DB06403; Ambrisentan.
DR DrugBank; DB01118; Amiodarone.
DR DrugBank; DB06288; Amisulpride.
DR DrugBank; DB00321; Amitriptyline.
DR DrugBank; DB00381; Amlodipine.
DR DrugBank; DB00613; Amodiaquine.
DR DrugBank; DB00701; Amprenavir.
DR DrugBank; DB00276; Amsacrine.
DR DrugBank; DB01217; Anastrozole.
DR DrugBank; DB06420; Annamycin.
DR DrugBank; DB11901; Apalutamide.
DR DrugBank; DB06605; Apixaban.
DR DrugBank; DB05676; Apremilast.
DR DrugBank; DB01169; Arsenic trioxide.
DR DrugBank; DB09274; Artesunate.
DR DrugBank; DB12597; Asciminib.
DR DrugBank; DB00637; Astemizole.
DR DrugBank; DB11586; Asunaprevir.
DR DrugBank; DB01072; Atazanavir.
DR DrugBank; DB16098; Atogepant.
DR DrugBank; DB01076; Atorvastatin.
DR DrugBank; DB01117; Atovaquone.
DR DrugBank; DB00171; ATP.
DR DrugBank; DB15011; Avacopan.
DR DrugBank; DB06237; Avanafil.
DR DrugBank; DB15233; Avapritinib.
DR DrugBank; DB11995; Avatrombopag.
DR DrugBank; DB06626; Axitinib.
DR DrugBank; DB00993; Azathioprine.
DR DrugBank; DB00972; Azelastine.
DR DrugBank; DB08822; Azilsartan medoxomil.
DR DrugBank; DB00207; Azithromycin.
DR DrugBank; DB11817; Baricitinib.
DR DrugBank; DB00394; Beclomethasone dipropionate.
DR DrugBank; DB15719; Belantamab mafodotin.
DR DrugBank; DB05015; Belinostat.
DR DrugBank; DB16703; Belumosudil.
DR DrugBank; DB15463; Belzutifan.
DR DrugBank; DB01086; Benzocaine.
DR DrugBank; DB01244; Bepridil.
DR DrugBank; DB15982; Berotralstat.
DR DrugBank; DB00443; Betamethasone.
DR DrugBank; DB14669; Betamethasone phosphate.
DR DrugBank; DB12364; Betrixaban.
DR DrugBank; DB01128; Bicalutamide.
DR DrugBank; DB04851; Biricodar.
DR DrugBank; DB00612; Bisoprolol.
DR DrugBank; DB08873; Boceprevir.
DR DrugBank; DB00188; Bortezomib.
DR DrugBank; DB06616; Bosutinib.
DR DrugBank; DB01200; Bromocriptine.
DR DrugBank; DB01222; Budesonide.
DR DrugBank; DB00921; Buprenorphine.
DR DrugBank; DB00490; Buspirone.
DR DrugBank; DB06772; Cabazitaxel.
DR DrugBank; DB00248; Cabergoline.
DR DrugBank; DB11751; Cabotegravir.
DR DrugBank; DB04690; Camptothecin.
DR DrugBank; DB08907; Canagliflozin.
DR DrugBank; DB13919; Candesartan.
DR DrugBank; DB00796; Candesartan cilexetil.
DR DrugBank; DB11791; Capmatinib.
DR DrugBank; DB01197; Captopril.
DR DrugBank; DB00564; Carbamazepine.
DR DrugBank; DB08889; Carfilzomib.
DR DrugBank; DB01136; Carvedilol.
DR DrugBank; DB00520; Caspofungin.
DR DrugBank; DB01212; Ceftriaxone.
DR DrugBank; DB00482; Celecoxib.
DR DrugBank; DB09063; Ceritinib.
DR DrugBank; DB00439; Cerivastatin.
DR DrugBank; DB06419; Cethromycin.
DR DrugBank; DB00341; Cetirizine.
DR DrugBank; DB07565; Chloramphenicol succinate.
DR DrugBank; DB00608; Chloroquine.
DR DrugBank; DB00477; Chlorpromazine.
DR DrugBank; DB01239; Chlorprothixene.
DR DrugBank; DB04540; Cholesterol.
DR DrugBank; DB02659; Cholic Acid.
DR DrugBank; DB01340; Cilazapril.
DR DrugBank; DB00501; Cimetidine.
DR DrugBank; DB00537; Ciprofloxacin.
DR DrugBank; DB00215; Citalopram.
DR DrugBank; DB01211; Clarithromycin.
DR DrugBank; DB01190; Clindamycin.
DR DrugBank; DB00349; Clobazam.
DR DrugBank; DB00845; Clofazimine.
DR DrugBank; DB00882; Clomifene.
DR DrugBank; DB01242; Clomipramine.
DR DrugBank; DB00758; Clopidogrel.
DR DrugBank; DB00257; Clotrimazole.
DR DrugBank; DB00363; Clozapine.
DR DrugBank; DB09065; Cobicistat.
DR DrugBank; DB05239; Cobimetinib.
DR DrugBank; DB01394; Colchicine.
DR DrugBank; DB02587; Colforsin.
DR DrugBank; DB14062; Concanamycin A.
DR DrugBank; DB00872; Conivaptan.
DR DrugBank; DB00286; Conjugated estrogens.
DR DrugBank; DB12483; Copanlisib.
DR DrugBank; DB01380; Cortisone acetate.
DR DrugBank; DB08865; Crizotinib.
DR DrugBank; DB11672; Curcumin.
DR DrugBank; DB14635; Curcumin sulfate.
DR DrugBank; DB00091; Cyclosporine.
DR DrugBank; DB06695; Dabigatran etexilate.
DR DrugBank; DB08912; Dabrafenib.
DR DrugBank; DB09102; Daclatasvir.
DR DrugBank; DB11963; Dacomitinib.
DR DrugBank; DB00970; Dactinomycin.
DR DrugBank; DB06292; Dapagliflozin.
DR DrugBank; DB00080; Daptomycin.
DR DrugBank; DB12941; Darolutamide.
DR DrugBank; DB01264; Darunavir.
DR DrugBank; DB09183; Dasabuvir.
DR DrugBank; DB01254; Dasatinib.
DR DrugBank; DB00694; Daunorubicin.
DR DrugBank; DB04840; Debrisoquine.
DR DrugBank; DB01151; Desipramine.
DR DrugBank; DB00967; Desloratadine.
DR DrugBank; DB14071; Desmethylsertraline.
DR DrugBank; DB01234; Dexamethasone.
DR DrugBank; DB14649; Dexamethasone acetate.
DR DrugBank; DB09213; Dexibuprofen.
DR DrugBank; DB14068; Dexniguldipine.
DR DrugBank; DB14063; Dexverapamil.
DR DrugBank; DB00829; Diazepam.
DR DrugBank; DB00586; Diclofenac.
DR DrugBank; DB00255; Diethylstilbestrol.
DR DrugBank; DB01396; Digitoxin.
DR DrugBank; DB00390; Digoxin.
DR DrugBank; DB00320; Dihydroergotamine.
DR DrugBank; DB00343; Diltiazem.
DR DrugBank; DB08995; Diosmin.
DR DrugBank; DB00975; Dipyridamole.
DR DrugBank; DB01248; Docetaxel.
DR DrugBank; DB14067; Dofequidar.
DR DrugBank; DB08930; Dolutegravir.
DR DrugBank; DB01184; Domperidone.
DR DrugBank; DB05928; Dovitinib.
DR DrugBank; DB00590; Doxazosin.
DR DrugBank; DB01142; Doxepin.
DR DrugBank; DB00997; Doxorubicin.
DR DrugBank; DB00470; Dronabinol.
DR DrugBank; DB04855; Dronedarone.
DR DrugBank; DB00476; Duloxetine.
DR DrugBank; DB11952; Duvelisib.
DR DrugBank; DB09075; Edoxaban.
DR DrugBank; DB04881; Elacridar.
DR DrugBank; DB11979; Elagolix.
DR DrugBank; DB11574; Elbasvir.
DR DrugBank; DB00216; Eletriptan.
DR DrugBank; DB15444; Elexacaftor.
DR DrugBank; DB09039; Eliglustat.
DR DrugBank; DB14064; Emopamil.
DR DrugBank; DB09038; Empagliflozin.
DR DrugBank; DB00584; Enalapril.
DR DrugBank; DB13874; Enasidenib.
DR DrugBank; DB13007; Enfortumab vedotin.
DR DrugBank; DB11986; Entrectinib.
DR DrugBank; DB08899; Enzalutamide.
DR DrugBank; DB00751; Epinastine.
DR DrugBank; DB12147; Erdafitinib.
DR DrugBank; DB01253; Ergometrine.
DR DrugBank; DB00696; Ergotamine.
DR DrugBank; DB00530; Erlotinib.
DR DrugBank; DB11827; Ertugliflozin.
DR DrugBank; DB00199; Erythromycin.
DR DrugBank; DB01175; Escitalopram.
DR DrugBank; DB00736; Esomeprazole.
DR DrugBank; DB00783; Estradiol.
DR DrugBank; DB13952; Estradiol acetate.
DR DrugBank; DB13953; Estradiol benzoate.
DR DrugBank; DB13954; Estradiol cypionate.
DR DrugBank; DB13955; Estradiol dienanthate.
DR DrugBank; DB13956; Estradiol valerate.
DR DrugBank; DB01196; Estramustine.
DR DrugBank; DB04573; Estriol.
DR DrugBank; DB14641; Estriol tripropionate.
DR DrugBank; DB00655; Estrone.
DR DrugBank; DB00977; Ethinylestradiol.
DR DrugBank; DB00773; Etoposide.
DR DrugBank; DB06414; Etravirine.
DR DrugBank; DB01590; Everolimus.
DR DrugBank; DB00973; Ezetimibe.
DR DrugBank; DB12466; Favipiravir.
DR DrugBank; DB12500; Fedratinib.
DR DrugBank; DB01023; Felodipine.
DR DrugBank; DB00813; Fentanyl.
DR DrugBank; DB06702; Fesoterodine.
DR DrugBank; DB00950; Fexofenadine.
DR DrugBank; DB08874; Fidaxomicin.
DR DrugBank; DB14845; Filgotinib.
DR DrugBank; DB08868; Fingolimod.
DR DrugBank; DB01195; Flecainide.
DR DrugBank; DB04908; Flibanserin.
DR DrugBank; DB00196; Fluconazole.
DR DrugBank; DB00472; Fluoxetine.
DR DrugBank; DB00875; Flupentixol.
DR DrugBank; DB00623; Fluphenazine.
DR DrugBank; DB00690; Flurazepam.
DR DrugBank; DB13867; Fluticasone.
DR DrugBank; DB08906; Fluticasone furoate.
DR DrugBank; DB00588; Fluticasone propionate.
DR DrugBank; DB00176; Fluvoxamine.
DR DrugBank; DB05449; FM-VP4.
DR DrugBank; DB11796; Fostemsavir.
DR DrugBank; DB00674; Galantamine.
DR DrugBank; DB12923; Gallopamil.
DR DrugBank; DB00317; Gefitinib.
DR DrugBank; DB00441; Gemcitabine.
DR DrugBank; DB01645; Genistein.
DR DrugBank; DB12141; Gilteritinib.
DR DrugBank; DB11978; Glasdegib.
DR DrugBank; DB13879; Glecaprevir.
DR DrugBank; DB01016; Glyburide.
DR DrugBank; DB00027; Gramicidin D.
DR DrugBank; DB12836; Grapiprant.
DR DrugBank; DB11575; Grazoprevir.
DR DrugBank; DB00365; Grepafloxacin.
DR DrugBank; DB00502; Haloperidol.
DR DrugBank; DB14070; HM-30181.
DR DrugBank; DB14061; Hycanthone.
DR DrugBank; DB00741; Hydrocortisone.
DR DrugBank; DB14538; Hydrocortisone aceponate.
DR DrugBank; DB14539; Hydrocortisone acetate.
DR DrugBank; DB14540; Hydrocortisone butyrate.
DR DrugBank; DB14541; Hydrocortisone cypionate.
DR DrugBank; DB14542; Hydrocortisone phosphate.
DR DrugBank; DB14543; Hydrocortisone probutate.
DR DrugBank; DB14544; Hydrocortisone valerate.
DR DrugBank; DB01611; Hydroxychloroquine.
DR DrugBank; DB00557; Hydroxyzine.
DR DrugBank; DB12471; Ibrexafungerp.
DR DrugBank; DB01050; Ibuprofen.
DR DrugBank; DB09054; Idelalisib.
DR DrugBank; DB00619; Imatinib.
DR DrugBank; DB00458; Imipramine.
DR DrugBank; DB05039; Indacaterol.
DR DrugBank; DB00224; Indinavir.
DR DrugBank; DB00328; Indomethacin.
DR DrugBank; DB11886; Infigratinib.
DR DrugBank; DB05889; Inotuzumab ozogamicin.
DR DrugBank; DB00762; Irinotecan.
DR DrugBank; DB11633; Isavuconazole.
DR DrugBank; DB06636; Isavuconazonium.
DR DrugBank; DB11757; Istradefylline.
DR DrugBank; DB01167; Itraconazole.
DR DrugBank; DB08820; Ivacaftor.
DR DrugBank; DB00602; Ivermectin.
DR DrugBank; DB14568; Ivosidenib.
DR DrugBank; DB04845; Ixabepilone.
DR DrugBank; DB01587; Ketazolam.
DR DrugBank; DB01026; Ketoconazole.
DR DrugBank; DB00709; Lamivudine.
DR DrugBank; DB00555; Lamotrigine.
DR DrugBank; DB12799; Laniquidar.
DR DrugBank; DB00448; Lansoprazole.
DR DrugBank; DB01259; Lapatinib.
DR DrugBank; DB14723; Larotrectinib.
DR DrugBank; DB11732; Lasmiditan.
DR DrugBank; DB09027; Ledipasvir.
DR DrugBank; DB12825; Lefamulin.
DR DrugBank; DB11951; Lemborexant.
DR DrugBank; DB00480; Lenalidomide.
DR DrugBank; DB09078; Lenvatinib.
DR DrugBank; DB12070; Letermovir.
DR DrugBank; DB01006; Letrozole.
DR DrugBank; DB09237; Levamlodipine.
DR DrugBank; DB01202; Levetiracetam.
DR DrugBank; DB01137; Levofloxacin.
DR DrugBank; DB05667; Levoketoconazole.
DR DrugBank; DB08918; Levomilnacipran.
DR DrugBank; DB00451; Levothyroxine.
DR DrugBank; DB00281; Lidocaine.
DR DrugBank; DB08882; Linagliptin.
DR DrugBank; DB00279; Liothyronine.
DR DrugBank; DB01583; Liotrix.
DR DrugBank; DB09198; Lobeglitazone.
DR DrugBank; DB14065; Lomerizine.
DR DrugBank; DB08827; Lomitapide.
DR DrugBank; DB06448; Lonafarnib.
DR DrugBank; DB16220; Lonapegsomatropin.
DR DrugBank; DB16222; Loncastuximab tesirine.
DR DrugBank; DB00836; Loperamide.
DR DrugBank; DB01601; Lopinavir.
DR DrugBank; DB00455; Loratadine.
DR DrugBank; DB00678; Losartan.
DR DrugBank; DB00227; Lovastatin.
DR DrugBank; DB14146; Loxicodegol.
DR DrugBank; DB09280; Lumacaftor.
DR DrugBank; DB12674; Lurbinectedin.
DR DrugBank; DB13125; Lusutrombopag.
DR DrugBank; DB06234; Maribavir.
DR DrugBank; DB00603; Medroxyprogesterone acetate.
DR DrugBank; DB00253; Medrysone.
DR DrugBank; DB00358; Mefloquine.
DR DrugBank; DB00351; Megestrol acetate.
DR DrugBank; DB00454; Meperidine.
DR DrugBank; DB00333; Methadone.
DR DrugBank; DB00563; Methotrexate.
DR DrugBank; DB09241; Methylene blue.
DR DrugBank; DB00959; Methylprednisolone.
DR DrugBank; DB01233; Metoclopramide.
DR DrugBank; DB00916; Metronidazole.
DR DrugBank; DB01388; Mibefradil.
DR DrugBank; DB01110; Miconazole.
DR DrugBank; DB00834; Mifepristone.
DR DrugBank; DB09031; Miltefosine.
DR DrugBank; DB08893; Mirabegron.
DR DrugBank; DB00648; Mitotane.
DR DrugBank; DB01204; Mitoxantrone.
DR DrugBank; DB16390; Mobocertinib.
DR DrugBank; DB11430; Monensin.
DR DrugBank; DB00295; Morphine.
DR DrugBank; DB00688; Mycophenolate mofetil.
DR DrugBank; DB01203; Nadolol.
DR DrugBank; DB01183; Naloxone.
DR DrugBank; DB00788; Naproxen.
DR DrugBank; DB03467; Naringenin.
DR DrugBank; DB01149; Nefazodone.
DR DrugBank; DB00220; Nelfinavir.
DR DrugBank; DB11828; Neratinib.
DR DrugBank; DB09048; Netupitant.
DR DrugBank; DB00622; Nicardipine.
DR DrugBank; DB01115; Nifedipine.
DR DrugBank; DB09239; Niguldipine.
DR DrugBank; DB04868; Nilotinib.
DR DrugBank; DB09079; Nintedanib.
DR DrugBank; DB16691; Nirmatrelvir.
DR DrugBank; DB00401; Nisoldipine.
DR DrugBank; DB01054; Nitrendipine.
DR DrugBank; DB00698; Nitrofurantoin.
DR DrugBank; DB00585; Nizatidine.
DR DrugBank; DB00717; Norethisterone.
DR DrugBank; DB00957; Norgestimate.
DR DrugBank; DB00540; Nortriptyline.
DR DrugBank; DB00104; Octreotide.
DR DrugBank; DB06670; Odanacatib.
DR DrugBank; DB16261; Odevixibat.
DR DrugBank; DB00334; Olanzapine.
DR DrugBank; DB09074; Olaparib.
DR DrugBank; DB00768; Olopatadine.
DR DrugBank; DB12455; Omadacycline.
DR DrugBank; DB09296; Ombitasvir.
DR DrugBank; DB00338; Omeprazole.
DR DrugBank; DB14069; ONT-093.
DR DrugBank; DB11632; Opicapone.
DR DrugBank; DB09330; Osimertinib.
DR DrugBank; DB00776; Oxcarbazepine.
DR DrugBank; DB12612; Ozanimod.
DR DrugBank; DB01229; Paclitaxel.
DR DrugBank; DB09073; Palbociclib.
DR DrugBank; DB01267; Paliperidone.
DR DrugBank; DB06603; Panobinostat.
DR DrugBank; DB00213; Pantoprazole.
DR DrugBank; DB09297; Paritaprevir.
DR DrugBank; DB00715; Paroxetine.
DR DrugBank; DB06589; Pazopanib.
DR DrugBank; DB15102; Pemigatinib.
DR DrugBank; DB00652; Pentazocine.
DR DrugBank; DB01174; Phenobarbital.
DR DrugBank; DB00252; Phenytoin.
DR DrugBank; DB13878; Pibrentasvir.
DR DrugBank; DB01100; Pimozide.
DR DrugBank; DB12582; Piperine.
DR DrugBank; DB08860; Pitavastatin.
DR DrugBank; DB02261; Platelet Activating Factor.
DR DrugBank; DB09287; Polyethylene glycol.
DR DrugBank; DB11077; Polyethylene glycol 400.
DR DrugBank; DB08910; Pomalidomide.
DR DrugBank; DB08901; Ponatinib.
DR DrugBank; DB01263; Posaconazole.
DR DrugBank; DB15822; Pralsetinib.
DR DrugBank; DB00175; Pravastatin.
DR DrugBank; DB00457; Prazosin.
DR DrugBank; DB00860; Prednisolone.
DR DrugBank; DB15566; Prednisolone acetate.
DR DrugBank; DB14631; Prednisolone phosphate.
DR DrugBank; DB00635; Prednisone.
DR DrugBank; DB01087; Primaquine.
DR DrugBank; DB00396; Progesterone.
DR DrugBank; DB01069; Promethazine.
DR DrugBank; DB01182; Propafenone.
DR DrugBank; DB00818; Propofol.
DR DrugBank; DB00571; Propranolol.
DR DrugBank; DB00344; Protriptyline.
DR DrugBank; DB06480; Prucalopride.
DR DrugBank; DB04216; Quercetin.
DR DrugBank; DB01224; Quetiapine.
DR DrugBank; DB01103; Quinacrine.
DR DrugBank; DB00908; Quinidine.
DR DrugBank; DB00468; Quinine.
DR DrugBank; DB00481; Raloxifene.
DR DrugBank; DB00863; Ranitidine.
DR DrugBank; DB00243; Ranolazine.
DR DrugBank; DB00234; Reboxetine.
DR DrugBank; DB08896; Regorafenib.
DR DrugBank; DB11853; Relugolix.
DR DrugBank; DB14761; Remdesivir.
DR DrugBank; DB00206; Reserpine.
DR DrugBank; DB11855; Revefenacin.
DR DrugBank; DB14072; Reversin 121.
DR DrugBank; DB03825; Rhodamine 6G.
DR DrugBank; DB00615; Rifabutin.
DR DrugBank; DB01045; Rifampicin.
DR DrugBank; DB11753; Rifamycin.
DR DrugBank; DB08864; Rilpivirine.
DR DrugBank; DB12457; Rimegepant.
DR DrugBank; DB08931; Riociguat.
DR DrugBank; DB14840; Ripretinib.
DR DrugBank; DB15305; Risdiplam.
DR DrugBank; DB00734; Risperidone.
DR DrugBank; DB00503; Ritonavir.
DR DrugBank; DB06228; Rivaroxaban.
DR DrugBank; DB09291; Rolapitant.
DR DrugBank; DB06176; Romidepsin.
DR DrugBank; DB00778; Roxithromycin.
DR DrugBank; DB12332; Rucaparib.
DR DrugBank; DB11544; Salinomycin.
DR DrugBank; DB00360; Sapropterin.
DR DrugBank; DB01232; Saquinavir.
DR DrugBank; DB12035; Sarecycline.
DR DrugBank; DB01037; Selegiline.
DR DrugBank; DB11362; Selexipag.
DR DrugBank; DB15685; Selpercatinib.
DR DrugBank; DB11689; Selumetinib.
DR DrugBank; DB01104; Sertraline.
DR DrugBank; DB00203; Sildenafil.
DR DrugBank; DB06207; Silodosin.
DR DrugBank; DB06290; Simeprevir.
DR DrugBank; DB00641; Simvastatin.
DR DrugBank; DB00877; Sirolimus.
DR DrugBank; DB01261; Sitagliptin.
DR DrugBank; DB08934; Sofosbuvir.
DR DrugBank; DB09099; Somatostatin.
DR DrugBank; DB00052; Somatotropin.
DR DrugBank; DB00398; Sorafenib.
DR DrugBank; DB15569; Sotorasib.
DR DrugBank; DB01208; Sparfloxacin.
DR DrugBank; DB03203; Sphingosine.
DR DrugBank; DB00421; Spironolactone.
DR DrugBank; DB01323; St. John's Wort.
DR DrugBank; DB02901; Stanolone.
DR DrugBank; DB13951; Stanolone acetate.
DR DrugBank; DB02010; Staurosporine.
DR DrugBank; DB00428; Streptozocin.
DR DrugBank; DB00391; Sulpiride.
DR DrugBank; DB00669; Sumatriptan.
DR DrugBank; DB01268; Sunitinib.
DR DrugBank; DB09034; Suvorexant.
DR DrugBank; DB00382; Tacrine.
DR DrugBank; DB00864; Tacrolimus.
DR DrugBank; DB11760; Talazoparib.
DR DrugBank; DB11770; Talinolol.
DR DrugBank; DB00675; Tamoxifen.
DR DrugBank; DB06240; Tariquidar.
DR DrugBank; DB04348; Taurocholic acid.
DR DrugBank; DB12887; Tazemetostat.
DR DrugBank; DB09161; Technetium Tc-99m sestamibi.
DR DrugBank; DB09160; Technetium Tc-99m tetrofosmin.
DR DrugBank; DB01079; Tegaserod.
DR DrugBank; DB05521; Telaprevir.
DR DrugBank; DB00966; Telmisartan.
DR DrugBank; DB00853; Temozolomide.
DR DrugBank; DB06287; Temsirolimus.
DR DrugBank; DB14126; Tenofovir.
DR DrugBank; DB09299; Tenofovir alafenamide.
DR DrugBank; DB00300; Tenofovir disoproxil.
DR DrugBank; DB15133; Tepotinib.
DR DrugBank; DB01162; Terazosin.
DR DrugBank; DB00342; Terfenadine.
DR DrugBank; DB04905; Tesmilifene.
DR DrugBank; DB13943; Testosterone cypionate.
DR DrugBank; DB13944; Testosterone enanthate.
DR DrugBank; DB01420; Testosterone propionate.
DR DrugBank; DB13946; Testosterone undecanoate.
DR DrugBank; DB14066; Tetrandrine.
DR DrugBank; DB11712; Tezacaftor.
DR DrugBank; DB08816; Ticagrelor.
DR DrugBank; DB00373; Timolol.
DR DrugBank; DB04960; Tipifarnib.
DR DrugBank; DB00932; Tipranavir.
DR DrugBank; DB16732; Tisotumab vedotin.
DR DrugBank; DB11800; Tivozanib.
DR DrugBank; DB11635; Tocofersolan.
DR DrugBank; DB11251; Tocopherol.
DR DrugBank; DB06212; Tolvaptan.
DR DrugBank; DB00273; Topiramate.
DR DrugBank; DB01030; Topotecan.
DR DrugBank; DB00539; Toremifene.
DR DrugBank; DB14962; Trastuzumab deruxtecan.
DR DrugBank; DB05773; Trastuzumab emtansine.
DR DrugBank; DB00656; Trazodone.
DR DrugBank; DB00831; Trifluoperazine.
DR DrugBank; DB00508; Triflupromazine.
DR DrugBank; DB15442; Trilaciclib.
DR DrugBank; DB00440; Trimethoprim.
DR DrugBank; DB00726; Trimipramine.
DR DrugBank; DB13179; Troleandomycin.
DR DrugBank; DB11652; Tucatinib.
DR DrugBank; DB09270; Ubidecarenone.
DR DrugBank; DB15328; Ubrogepant.
DR DrugBank; DB14989; Umbralisib.
DR DrugBank; DB09076; Umeclidinium.
DR DrugBank; DB15091; Upadacitinib.
DR DrugBank; DB14057; Valinomycin.
DR DrugBank; DB11869; Valspodar.
DR DrugBank; DB05294; Vandetanib.
DR DrugBank; DB00862; Vardenafil.
DR DrugBank; DB01339; Vecuronium.
DR DrugBank; DB11613; Velpatasvir.
DR DrugBank; DB08881; Vemurafenib.
DR DrugBank; DB11581; Venetoclax.
DR DrugBank; DB00285; Venlafaxine.
DR DrugBank; DB00661; Verapamil.
DR DrugBank; DB15456; Vericiguat.
DR DrugBank; DB14895; Vibegron.
DR DrugBank; DB04876; Vildagliptin.
DR DrugBank; DB00570; Vinblastine.
DR DrugBank; DB00541; Vincristine.
DR DrugBank; DB11641; Vinflunine.
DR DrugBank; DB08828; Vismodegib.
DR DrugBank; DB04877; Voacamine.
DR DrugBank; DB11693; Voclosporin.
DR DrugBank; DB09030; Vorapaxar.
DR DrugBank; DB12026; Voxilaprevir.
DR DrugBank; DB15035; Zanubrutinib.
DR DrugBank; DB00495; Zidovudine.
DR DrugBank; DB04832; Zimelidine.
DR DrugBank; DB00246; Ziprasidone.
DR DrugBank; DB00315; Zolmitriptan.
DR DrugBank; DB00909; Zonisamide.
DR DrugBank; DB06191; Zosuquidar.
DR DrugCentral; P08183; -.
DR GuidetoPHARMACOLOGY; 768; -.
DR SwissLipids; SLP:000000385; -.
DR MoonDB; P08183; Curated.
DR MoonProt; P08183; -.
DR TCDB; 3.A.1.201.1; the atp-binding cassette (abc) superfamily.
DR GlyGen; P08183; 4 sites, 1 O-linked glycan (1 site).
DR iPTMnet; P08183; -.
DR PhosphoSitePlus; P08183; -.
DR BioMuta; ABCB1; -.
DR DMDM; 238054374; -.
DR EPD; P08183; -.
DR jPOST; P08183; -.
DR MassIVE; P08183; -.
DR MaxQB; P08183; -.
DR PaxDb; P08183; -.
DR PeptideAtlas; P08183; -.
DR PRIDE; P08183; -.
DR ProteomicsDB; 52080; -. [P08183-1]
DR ProteomicsDB; 5934; -.
DR ABCD; P08183; 3 sequenced antibodies.
DR Antibodypedia; 3443; 1440 antibodies from 51 providers.
DR CPTC; P08183; 6 antibodies.
DR DNASU; 5243; -.
DR Ensembl; ENST00000265724.8; ENSP00000265724.3; ENSG00000085563.15. [P08183-1]
DR Ensembl; ENST00000543898.5; ENSP00000444095.1; ENSG00000085563.15. [P08183-2]
DR Ensembl; ENST00000622132.5; ENSP00000478255.1; ENSG00000085563.15. [P08183-1]
DR GeneID; 5243; -.
DR KEGG; hsa:5243; -.
DR MANE-Select; ENST00000622132.5; ENSP00000478255.1; NM_001348946.2; NP_001335875.1.
DR UCSC; uc003uiz.3; human. [P08183-1]
DR CTD; 5243; -.
DR DisGeNET; 5243; -.
DR GeneCards; ABCB1; -.
DR HGNC; HGNC:40; ABCB1.
DR HPA; ENSG00000085563; Tissue enhanced (adrenal gland, intestine).
DR MalaCards; ABCB1; -.
DR MIM; 171050; gene.
DR MIM; 612244; phenotype.
DR neXtProt; NX_P08183; -.
DR OpenTargets; ENSG00000085563; -.
DR Orphanet; 771; NON RARE IN EUROPE: Ulcerative colitis.
DR Orphanet; 619277; Prediction of antihistamines toxicity.
DR Orphanet; 574637; Prediction of ivermectin toxicity.
DR Orphanet; 529825; Prediction of resistance to colchicine.
DR Orphanet; 413667; Prediction of toxicity or dose selection of antidepressants or antipsychotics.
DR PharmGKB; PA267; -.
DR VEuPathDB; HostDB:ENSG00000085563; -.
DR eggNOG; KOG0055; Eukaryota.
DR GeneTree; ENSGT00940000155287; -.
DR HOGENOM; CLU_000604_17_2_1; -.
DR InParanoid; P08183; -.
DR OMA; RSDANFW; -.
DR OrthoDB; 186078at2759; -.
DR PhylomeDB; P08183; -.
DR TreeFam; TF105193; -.
DR BioCyc; MetaCyc:HS01500-MON; -.
DR BRENDA; 7.6.2.2; 2681.
DR BRENDA; 7.6.2.3; 2681.
DR PathwayCommons; P08183; -.
DR Reactome; R-HSA-2161517; Abacavir transmembrane transport.
DR Reactome; R-HSA-382556; ABC-family proteins mediated transport.
DR Reactome; R-HSA-9754706; Atorvastatin ADME.
DR SignaLink; P08183; -.
DR SIGNOR; P08183; -.
DR BioGRID-ORCS; 5243; 17 hits in 1076 CRISPR screens.
DR ChiTaRS; ABCB1; human.
DR GeneWiki; P-glycoprotein; -.
DR GenomeRNAi; 5243; -.
DR Pharos; P08183; Tchem.
DR PRO; PR:P08183; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P08183; protein.
DR Bgee; ENSG00000085563; Expressed in right adrenal gland and 155 other tissues.
DR ExpressionAtlas; P08183; baseline and differential.
DR Genevisible; P08183; HS.
DR GO; GO:0016324; C:apical plasma membrane; IDA:ARUK-UCL.
DR GO; GO:0009986; C:cell surface; IDA:DFLAT.
DR GO; GO:0098591; C:external side of apical plasma membrane; ISS:ARUK-UCL.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IDA:ARUK-UCL.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR GO; GO:0008559; F:ABC-type xenobiotic transporter activity; IDA:ARUK-UCL.
DR GO; GO:0005524; F:ATP binding; IDA:ARUK-UCL.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IDA:ARUK-UCL.
DR GO; GO:0046943; F:carboxylic acid transmembrane transporter activity; IMP:ARUK-UCL.
DR GO; GO:0099038; F:ceramide floppase activity; IDA:BHF-UCL.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IDA:ARUK-UCL.
DR GO; GO:0140328; F:floppase activity; IMP:UniProtKB.
DR GO; GO:0090554; F:phosphatidylcholine floppase activity; IDA:BHF-UCL.
DR GO; GO:0090555; F:phosphatidylethanolamine flippase activity; IDA:BHF-UCL.
DR GO; GO:0022857; F:transmembrane transporter activity; ISS:ARUK-UCL.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:ARUK-UCL.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IDA:ARUK-UCL.
DR GO; GO:1905039; P:carboxylic acid transmembrane transport; IMP:ARUK-UCL.
DR GO; GO:0099040; P:ceramide translocation; IDA:BHF-UCL.
DR GO; GO:0140115; P:export across plasma membrane; IDA:ARUK-UCL.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IDA:DFLAT.
DR GO; GO:0045332; P:phospholipid translocation; IDA:BHF-UCL.
DR GO; GO:1901529; P:positive regulation of anion channel activity; IMP:CAFA.
DR GO; GO:2001225; P:regulation of chloride transport; IMP:CAFA.
DR GO; GO:0047484; P:regulation of response to osmotic stress; IMP:CAFA.
DR GO; GO:0009410; P:response to xenobiotic stimulus; TAS:ProtInc.
DR GO; GO:0072089; P:stem cell proliferation; IMP:DFLAT.
DR GO; GO:0046865; P:terpenoid transport; ISS:ARUK-UCL.
DR GO; GO:0070633; P:transepithelial transport; IDA:ARUK-UCL.
DR GO; GO:0055085; P:transmembrane transport; TAS:Reactome.
DR GO; GO:0150104; P:transport across blood-brain barrier; NAS:ARUK-UCL.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IDA:ARUK-UCL.
DR GO; GO:1990962; P:xenobiotic transport across blood-brain barrier; IMP:ARUK-UCL.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR030258; MDR1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR PANTHER; PTHR24221:SF251; PTHR24221:SF251; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; ATP-binding; Cell membrane;
KW Glycoprotein; Lipid transport; Membrane; Nucleotide-binding;
KW Phosphoprotein; Reference proteome; Repeat; Translocase; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..1280
FT /note="ATP-dependent translocase ABCB1"
FT /id="PRO_0000093332"
FT TOPO_DOM 1..44
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 45..67
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 68..116
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 138..186
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 187..208
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 209..215
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 237..292
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 293..316
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 317..330
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 331..352
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 353..711
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 712..732
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 733..756
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 757..777
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 778..832
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 833..853
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 854
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 855..874
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 875..934
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 935..957
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 958..973
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 974..995
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 996..1280
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT DOMAIN 51..357
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 392..628
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 711..1000
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 1035..1273
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 646..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 427..434
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1070..1077
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT MOD_RES 660
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P06795"
FT CARBOHYD 91
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 113..177
FT /note="RYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFD
FT VHDVGELNTRLTD -> S (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_055769"
FT VARIANT 17
FT /note="F -> L (in dbSNP:rs28381804)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_022276"
FT VARIANT 21
FT /note="N -> D (in dbSNP:rs9282564)"
FT /evidence="ECO:0000269|PubMed:10716719,
FT ECO:0000269|PubMed:10790226, ECO:0000269|PubMed:11240981,
FT ECO:0000269|PubMed:14702039, ECO:0000269|Ref.5"
FT /id="VAR_014704"
FT VARIANT 44
FT /note="N -> S (in dbSNP:rs1202183)"
FT /id="VAR_055423"
FT VARIANT 80
FT /note="A -> E (in dbSNP:rs9282565)"
FT /id="VAR_055424"
FT VARIANT 103
FT /note="F -> L"
FT /evidence="ECO:0000269|PubMed:10716719"
FT /id="VAR_015001"
FT VARIANT 108
FT /note="E -> K"
FT /evidence="ECO:0000269|PubMed:15618700"
FT /id="VAR_018351"
FT VARIANT 185
FT /note="G -> V (in a colchicine-selected multidrug-resistant
FT cell line; confers increased resistance to colchicine;
FT dbSNP:rs1128501)"
FT /evidence="ECO:0000269|PubMed:2876781,
FT ECO:0000269|PubMed:2897240, ECO:0000269|PubMed:9038218"
FT /id="VAR_015002"
FT VARIANT 261
FT /note="I -> V (in dbSNP:rs36008564)"
FT /id="VAR_055425"
FT VARIANT 400
FT /note="S -> N (in dbSNP:rs2229109)"
FT /evidence="ECO:0000269|PubMed:10716719,
FT ECO:0000269|PubMed:11240981, ECO:0000269|Ref.5"
FT /id="VAR_015003"
FT VARIANT 566
FT /note="E -> K (in dbSNP:rs28381902)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_022277"
FT VARIANT 593
FT /note="R -> C (in dbSNP:rs28381914)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_022278"
FT VARIANT 599
FT /note="A -> T (in dbSNP:rs2235036)"
FT /id="VAR_055426"
FT VARIANT 669
FT /note="R -> C (in dbSNP:rs35023033)"
FT /id="VAR_055427"
FT VARIANT 801
FT /note="V -> M (in dbSNP:rs2235039)"
FT /id="VAR_055428"
FT VARIANT 829
FT /note="I -> V (in dbSNP:rs2032581)"
FT /id="VAR_055429"
FT VARIANT 836
FT /note="I -> V (in dbSNP:rs28381967)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_022279"
FT VARIANT 887
FT /note="K -> N (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035737"
FT VARIANT 893
FT /note="S -> A (common allele; associated with
FT susceptibility to IBD13; has decreased enzyme activity;
FT dbSNP:rs2032582)"
FT /evidence="ECO:0000269|PubMed:11240981,
FT ECO:0000269|PubMed:11829140, ECO:0000269|PubMed:14610718,
FT ECO:0000269|PubMed:1967175, ECO:0000269|PubMed:2876781,
FT ECO:0000269|PubMed:9038218, ECO:0000269|PubMed:9473242,
FT ECO:0000269|Ref.5"
FT /id="VAR_013361"
FT VARIANT 893
FT /note="S -> T (rare allele; dbSNP:rs2032582)"
FT /evidence="ECO:0000269|PubMed:11240981,
FT ECO:0000269|PubMed:11829140, ECO:0000269|PubMed:14610718"
FT /id="VAR_013362"
FT VARIANT 986
FT /note="M -> V (in dbSNP:rs926081975)"
FT /id="VAR_018352"
FT VARIANT 999
FT /note="A -> T (in dbSNP:rs72552784)"
FT /evidence="ECO:0000269|PubMed:9473242"
FT /id="VAR_015004"
FT VARIANT 1051
FT /note="P -> A (in dbSNP:rs28401798)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_022280"
FT VARIANT 1107
FT /note="Q -> P (in dbSNP:rs55852620)"
FT /evidence="ECO:0000269|PubMed:11240981"
FT /id="VAR_015005"
FT VARIANT 1141
FT /note="S -> T (in dbSNP:rs2229107)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_022281"
FT VARIANT 1251
FT /note="V -> I (in dbSNP:rs28364274)"
FT /evidence="ECO:0000269|PubMed:15618713, ECO:0000269|Ref.5"
FT /id="VAR_018353"
FT CONFLICT 23
FT /note="S -> R (in Ref. 9; CAA41558)"
FT /evidence="ECO:0000305"
FT CONFLICT 336
FT /note="Missing (in Ref. 3; AAB69423)"
FT /evidence="ECO:0000305"
FT TURN 37..39
FT /evidence="ECO:0007829|PDB:7A69"
FT TURN 40..42
FT /evidence="ECO:0007829|PDB:7O9W"
FT HELIX 45..80
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 107..156
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 162..165
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 168..186
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 188..210
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 212..236
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 241..257
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 261..267
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 270..322
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 328..346
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 349..370
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 377..379
FT /evidence="ECO:0007829|PDB:7A6F"
FT STRAND 392..398
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 402..404
FT /evidence="ECO:0007829|PDB:7O9W"
FT STRAND 410..412
FT /evidence="ECO:0007829|PDB:6C0V"
FT STRAND 415..417
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 422..426
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 433..440
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 447..457
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 458..460
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 463..468
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 470..473
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 481..483
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 484..489
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 497..506
FT /evidence="ECO:0007829|PDB:7A69"
FT TURN 507..510
FT /evidence="ECO:0007829|PDB:7A6F"
FT HELIX 511..515
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 516..518
FT /evidence="ECO:0007829|PDB:7A69"
FT TURN 519..521
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 526..528
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 533..545
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 550..556
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 559..561
FT /evidence="ECO:0007829|PDB:6C0V"
FT HELIX 563..573
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 578..585
FT /evidence="ECO:0007829|PDB:7A69"
FT TURN 590..594
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 595..602
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 605..608
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 612..618
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 621..629
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 700..703
FT /evidence="ECO:0007829|PDB:7A69"
FT TURN 704..706
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 708..736
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 739..742
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 745..797
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 801..804
FT /evidence="ECO:0007829|PDB:7A69"
FT TURN 808..811
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 812..853
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 855..861
FT /evidence="ECO:0007829|PDB:7A69"
FT TURN 862..864
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 865..880
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 887..902
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 904..910
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 914..965
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 971..981
FT /evidence="ECO:0007829|PDB:7A69"
FT TURN 982..985
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 986..994
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 999..1013
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 1035..1041
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 1045..1047
FT /evidence="ECO:0007829|PDB:6C0V"
FT STRAND 1048..1052
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 1056..1060
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 1066..1069
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 1074..1077
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 1078..1083
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 1090..1096
FT /evidence="ECO:0007829|PDB:7A69"
FT TURN 1101..1103
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 1106..1112
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 1114..1116
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 1124..1126
FT /evidence="ECO:0007829|PDB:6C0V"
FT HELIX 1128..1131
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 1142..1151
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 1155..1159
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 1161..1163
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 1164..1166
FT /evidence="ECO:0007829|PDB:6C0V"
FT HELIX 1171..1173
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 1178..1190
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 1195..1201
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 1208..1222
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 1225..1230
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 1235..1238
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 1240..1247
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 1250..1256
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 1257..1262
FT /evidence="ECO:0007829|PDB:7A69"
FT HELIX 1266..1271
FT /evidence="ECO:0007829|PDB:7A69"
FT STRAND 1272..1274
FT /evidence="ECO:0007829|PDB:7O9W"
SQ SEQUENCE 1280 AA; 141479 MW; F0230744AB288C73 CRC64;
MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY MVVGTLAAII
HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND TGFFMNLEED MTRYAYYYSG
IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS
KINEGIGDKI GMFFQSMATF FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT
DKELLAYAKA GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG
AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFFSVLI GAFSVGQASP SIEAFANARG
AAYEIFKIID NKPSIDSYSK SGHKPDNIKG NLEFRNVHFS YPSRKEVKIL KGLNLKVQSG
QTVALVGNSG CGKSTTVQLM QRLYDPTEGM VSVDGQDIRT INVRFLREII GVVSQEPVLF
ATTIAENIRY GRENVTMDEI EKAVKEANAY DFIMKLPHKF DTLVGERGAQ LSGGQKQRIA
IARALVRNPK ILLLDEATSA LDTESEAVVQ VALDKARKGR TTIVIAHRLS TVRNADVIAG
FDDGVIVEKG NHDELMKEKG IYFKLVTMQT AGNEVELENA ADESKSEIDA LEMSSNDSRS
SLIRKRSTRR SVRGSQAQDR KLSTKEALDE SIPPVSFWRI MKLNLTEWPY FVVGVFCAII
NGGLQPAFAI IFSKIIGVFT RIDDPETKRQ NSNLFSLLFL ALGIISFITF FLQGFTFGKA
GEILTKRLRY MVFRSMLRQD VSWFDDPKNT TGALTTRLAN DAAQVKGAIG SRLAVITQNI
ANLGTGIIIS FIYGWQLTLL LLAIVPIIAI AGVVEMKMLS GQALKDKKEL EGSGKIATEA
IENFRTVVSL TQEQKFEHMY AQSLQVPYRN SLRKAHIFGI TFSFTQAMMY FSYAGCFRFG
AYLVAHKLMS FEDVLLVFSA VVFGAMAVGQ VSSFAPDYAK AKISAAHIIM IIEKTPLIDS
YSTEGLMPNT LEGNVTFGEV VFNYPTRPDI PVLQGLSLEV KKGQTLALVG SSGCGKSTVV
QLLERFYDPL AGKVLLDGKE IKRLNVQWLR AHLGIVSQEP ILFDCSIAEN IAYGDNSRVV
SQEEIVRAAK EANIHAFIES LPNKYSTKVG DKGTQLSGGQ KQRIAIARAL VRQPHILLLD
EATSALDTES EKVVQEALDK AREGRTCIVI AHRLSTIQNA DLIVVFQNGR VKEHGTHQQL
LAQKGIYFSM VSVQAGTKRQ
