ID   MDR4_ENTHI              Reviewed;         113 AA.
AC   P16877;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Multidrug resistance protein 4;
DE   AltName: Full=P-glycoprotein;
DE   Flags: Fragment;
GN   Name=MDR4;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1970121; DOI=10.1016/0166-6851(90)90031-g;
RA   Samuelson J., Ayala P., Orozco E., Wirth D.;
RT   "Emetine-resistant mutants of Entamoeba histolytica overexpress mRNAs for
RT   multidrug resistance.";
RL   Mol. Biochem. Parasitol. 38:281-290(1990).
CC   -!- FUNCTION: Energy-dependent efflux pump responsible for decreased drug
CC       accumulation in multidrug-resistant cells.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC       Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.
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DR   EMBL; M29060; AAA29109.1; -; Genomic_DNA.
DR   PIR; C44970; C44970.
DR   AlphaFoldDB; P16877; -.
DR   SMR; P16877; -.
DR   STRING; 5759.rna_EHI_186350-1; -.
DR   VEuPathDB; AmoebaDB:EHI5A_266680; -.
DR   VEuPathDB; AmoebaDB:EHI_186350; -.
DR   VEuPathDB; AmoebaDB:KM1_243070; -.
DR   eggNOG; KOG0055; Eukaryota.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039421; Type_1_exporter.
DR   PANTHER; PTHR24221; PTHR24221; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Membrane; Nucleotide-binding; Repeat; Transmembrane;
KW   Transport.
FT   CHAIN           <1..>113
FT                   /note="Multidrug resistance protein 4"
FT                   /id="PRO_0000093374"
FT   NON_TER         1
FT   NON_TER         113
SQ   SEQUENCE   113 AA;  12394 MW;  12DE897599E7826A CRC64;
     SGCGKSTSVQ LIERFYDPTH GDVLLDGHNI RFEYSFLRSQ IGMVGQEPVL FAESVMDNIR
     RGVPKGVEVS NEQIYAAAKM ANAHDFISAM PEGYNTMVGD RGAQISGGQK QRI