ID   ARGR_PSEAE              Reviewed;         329 AA.
AC   G3XCU2;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=HTH-type transcriptional regulator ArgR {ECO:0000303|PubMed:19850617};
GN   Name=argR; OrderedLocusNames=PA0893;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   FUNCTION.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=19850617; DOI=10.1099/mic.0.033282-0;
RA   Li C., Yao X., Lu C.D.;
RT   "Regulation of the dauBAR operon and characterization of D-amino acid
RT   dehydrogenase DauA in arginine and lysine catabolism of Pseudomonas
RT   aeruginosa PAO1.";
RL   Microbiology 156:60-71(2010).
CC   -!- FUNCTION: ArgR could be a transcriptional activator of the dauBAR
CC       operon in response to the presence of L-Arg.
CC       {ECO:0000305|PubMed:19850617}.
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DR   EMBL; AE004091; AAG04282.1; -; Genomic_DNA.
DR   PIR; T44459; T44459.
DR   RefSeq; NP_249584.1; NC_002516.2.
DR   RefSeq; WP_003085944.1; NZ_QZGE01000007.1.
DR   AlphaFoldDB; G3XCU2; -.
DR   SMR; G3XCU2; -.
DR   STRING; 287.DR97_1050; -.
DR   PaxDb; G3XCU2; -.
DR   PRIDE; G3XCU2; -.
DR   DNASU; 879434; -.
DR   EnsemblBacteria; AAG04282; AAG04282; PA0893.
DR   GeneID; 879434; -.
DR   KEGG; pae:PA0893; -.
DR   PseudoCAP; PA0893; -.
DR   HOGENOM; CLU_000445_59_0_6; -.
DR   InParanoid; G3XCU2; -.
DR   OMA; QRVHPEV; -.
DR   PhylomeDB; G3XCU2; -.
DR   Proteomes; UP000002438; Chromosome.
DR   CollecTF; EXPREG_00000470; -.
DR   GO; GO:0032993; C:protein-DNA complex; IMP:CollecTF.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IMP:CollecTF.
DR   GO; GO:0001217; F:DNA-binding transcription repressor activity; IPI:CollecTF.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IMP:CollecTF.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; EXP:CollecTF.
DR   GO; GO:1900079; P:regulation of arginine biosynthetic process; IMP:PseudoCAP.
DR   GO; GO:1900081; P:regulation of arginine catabolic process; IMP:PseudoCAP.
DR   Gene3D; 3.40.50.880; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..329
FT                   /note="HTH-type transcriptional regulator ArgR"
FT                   /id="PRO_0000433134"
FT   DOMAIN          214..312
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        231..252
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        279..302
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   REGION          307..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   329 AA;  36854 MW;  0BA58B7AB1405E80 CRC64;
     MTAQPQRIGF LLWPATRALT LSLAEEALRA ARRLHPEALY EPLFLLAEAP AEEEGWRLPG
     TAWNGRLEQC SRLFLVADEA PAAVSPALGL ALKQLARSGA AIGALSAGIY PLAQLGLLDG
     YRAAVHWRWH DDFTERFPKV IATNHLFEWD RDRMTACGGM AVLDLLLALL SRDHGAELAG
     AVSEELVVER IREGNERQRI PLKNRLGSSH PKLTQAVLLM EANIEEPLTT DEIAQHVCVS
     RRQLERIFKQ YLNRVPSQYY LELRLNRARQ MLMQTSKSII QIGLSCGFSS GPHFSSAYRN
     FFGVTPREDR NQRRGGSAFE TTFTPVERG