ID   MDTA_CROTZ              Reviewed;         415 AA.
AC   C9XVZ5;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 2.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=Ctu_27700;
OS   Cronobacter turicensis (strain DSM 18703 / CCUG 55852 / LMG 23827 / z3032).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Cronobacter.
OX   NCBI_TaxID=693216;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18703 / CCUG 55852 / LMG 23827 / z3032;
RX   PubMed=21037008; DOI=10.1128/jb.01162-10;
RA   Stephan R., Lehner A., Tischler P., Rattei T.;
RT   "Complete genome sequence of Cronobacter turicensis LMG 23827, a food-borne
RT   pathogen causing deaths in neonates.";
RL   J. Bacteriol. 193:309-310(2011).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CBA32144.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; FN543093; CBA32144.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041923730.1; NC_013282.2.
DR   AlphaFoldDB; C9XVZ5; -.
DR   SMR; C9XVZ5; -.
DR   EnsemblBacteria; CBA32144; CBA32144; CTU_27700.
DR   GeneID; 60374270; -.
DR   KEGG; ctu:CTU_27700; -.
DR   PATRIC; fig|693216.3.peg.2618; -.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   Proteomes; UP000002069; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Signal; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           22..415
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_0000414042"
FT   REGION          387..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        393..407
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   415 AA;  43993 MW;  C2F3A865A95EAC31 CRC64;
     MKSTVKKRGW VIAGIVVVAL AALLYWRYAA TEAPSGKAQH AGGRAAMRMG SAPAPVQAAT
     ARSEAVPRYL TGLGTITAAN TVTVRSRVDG QLMAIHFKEG QQVKAGDLLA EIDPSQFKVA
     LAQAQGQLAK DRATLANARR DLARYQQLGK TNLVSRQELD AQQALVSESE GTLKADEAAV
     ASAQLQLDWS RITAPIDGRV GLKQVDIGNQ ISSGDTTGIV VLTQTHPIDL VFTLPESDIA
     AVMQAQKAGK PLTVEAWDRT NSTKLSTGEL LSLDNQIDAT TGTIKLKARF ANEDDALFPN
     QFVNARMLID TQQNAVVIPT AALQMGNEGH FVWVLNDDNK VSKHTVTTGI QNSESVVITA
     GLSAGDRVVT DGIDRLTEGA KVDVVEAQTA ADAAKPERGE RAPTDSARAA KGARS