ID   MDTA_DICZ5              Reviewed;         421 AA.
AC   D2BTK6;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=Dd586_3002;
OS   Dickeya zeae (strain Ech586) (Dickeya dadantii (strain Ech586)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Dickeya; Dickeya parazeae.
OX   NCBI_TaxID=590409;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ech586;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C.,
RA   Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Balakrishnan V., Glasner J., Perna N.T.;
RT   "Complete sequence of Dickeya dadantii Ech586.";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; CP001836; ACZ77837.1; -; Genomic_DNA.
DR   AlphaFoldDB; D2BTK6; -.
DR   SMR; D2BTK6; -.
DR   STRING; 590409.Dd586_3002; -.
DR   EnsemblBacteria; ACZ77837; ACZ77837; Dd586_3002.
DR   KEGG; ddc:Dd586_3002; -.
DR   eggNOG; COG0845; Bacteria.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   Proteomes; UP000001446; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Signal; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           23..421
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_0000414043"
FT   REGION          34..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          395..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        405..421
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   421 AA;  45627 MW;  163A0A701FF466D5 CRC64;
     MNAARLFRFL ILLVVIAAAF FAWRYFRPSQ SDSANEATTT QHASPQGQGQ NRSGSGRRGS
     TAPPPVQAAL SSSSSVPYYL SGLGTVTAAN TVTVHSRVSG QLMAIHFQEG QQVKEGELLA
     EIDPRPFQVA LIQAQGQLAK DQALLVNARQ DLVRYQQLSK TNLVSGQQLD TQESLVRQYE
     ATVKSDQGAV ASAQLQLDYS RITAPFNGRV GLRQIDIGNY VTSTDNLLVL TQTHPIDVIF
     TVPESDIATV LKAQKSGQPV PVEAWDRGSQ RILSQGRLLS MDNQIDATTG TIKLKARFDN
     TDDALFPNQF VNIKMKVDTL QNVVIAPSAA IQMGNEGHFI WVLNDKDQVS KHIITTGIQY
     GQQTVVSNGL NAGERVVTDG IDRLTEGARV EVLAPAAADS KSTAGAEKPQ HEKSQHNAEK
     S