ID   MDTA_ECO7I              Reviewed;         415 AA.
AC   B7NQB2;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422};
GN   OrderedLocusNames=ECIAI39_0940;
OS   Escherichia coli O7:K1 (strain IAI39 / ExPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IAI39 / ExPEC;
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- FUNCTION: The MdtABC tripartite complex confers resistance against
CC       novobiocin and deoxycholate. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- INDUCTION: The mdtABC operon is transcriptionally activated by BaeR.
CC       {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; CU928164; CAR17077.1; -; Genomic_DNA.
DR   RefSeq; WP_000678979.1; NC_011750.1.
DR   RefSeq; YP_002406962.1; NC_011750.1.
DR   AlphaFoldDB; B7NQB2; -.
DR   SMR; B7NQB2; -.
DR   STRING; 585057.ECIAI39_0940; -.
DR   EnsemblBacteria; CAR17077; CAR17077; ECIAI39_0940.
DR   KEGG; ect:ECIAI39_0940; -.
DR   PATRIC; fig|585057.6.peg.990; -.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   Proteomes; UP000000749; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Signal; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           22..415
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_1000145636"
FT   REGION          32..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   415 AA;  44498 MW;  20A79B4FD23633ED CRC64;
     MKGSYKSRWV IVIVVVIAAI AAFWFWQGRN DSRSAAPGAT KQAQQSPAGG RRGMRAGPLA
     PVQAATAVEQ AVPRYLTGLG TITAANTVTV RSRVDGQLMA LHFQEGQQVK AGDLLAEIDP
     SQFKVALAQA QGQLAKDKAT LANARRDLAR YQQLVKTNLV SRQELDAQQA LVSETEGTIK
     ADEASVASAQ LQLDWSRITA PVDGRVGLKQ VDVGNQISSG DTTGIVVITQ THPIDLLFTL
     PESDIATVVQ AQKAGKPLVV EAWDRTNSKK LSEGTLLSLD NQIDATTGTI KVKARFNNQD
     DALFPNQFVN ARMLVDTEQN AVVIPTAALQ MGNEGHFVWV LNSENKVSKH LVTPGIQDSQ
     KVVIRAGISA GDRVVTDGID RLTEGAKVEV VEAQSATTSE EKATSREYAK KGARS