ID   MDTA_EDWI9              Reviewed;         408 AA.
AC   C5BHN6;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=NT01EI_1172;
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001600; ACR68380.1; -; Genomic_DNA.
DR   RefSeq; WP_015870554.1; NC_012779.2.
DR   AlphaFoldDB; C5BHN6; -.
DR   SMR; C5BHN6; -.
DR   STRING; 67780.B6E78_16175; -.
DR   EnsemblBacteria; ACR68380; ACR68380; NT01EI_1172.
DR   GeneID; 7960918; -.
DR   KEGG; eic:NT01EI_1172; -.
DR   PATRIC; fig|634503.3.peg.1062; -.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   OrthoDB; 1432684at2; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Signal;
KW   Transport.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           29..408
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_0000414044"
FT   REGION          35..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   408 AA;  44077 MW;  8F6678793F1501F9 CRC64;
     MSLLSALSSR RARLCGLLII LLLLGAVAWQ GFSAAPPSGA SGSPARQSGA KPGRGMTQAI
     PVQAAAVRRA EQDSYLSGLG TVTASNTVTV RSRVDGQLMK LHFSEGEQVK AGDLLAEIDP
     RPFLIQLQQA QGALARDTAL LDNARRDLAR YQRLAKDNLV SRQELDTQAS LVTQTQASLV
     SDRANVDNAQ LQLDYSRIRA PGDGRAGLRQ VDEGNYISSA DTNGLVVLTQ THPIDVLFTL
     PEGDIPRLQQ ALQHQGTLVA EAWDRSDRQR LATGHLLSLD NQIDTATGTL KIKARFENQD
     DRLFPNQFVN LRLQVASQMP VLLIPAAAVQ TGREGRFVWV VDAGNRVHKR SLSVGARDGE
     SLVVLQGVDE GEKVVTDGID RLTEDARVDI IAARRPGAAA DQEDTQQP