ID   MDTA_ENT38              Reviewed;         411 AA.
AC   A4WCC0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=Ent638_2684;
OS   Enterobacter sp. (strain 638).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter.
OX   NCBI_TaxID=399742;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=638;
RX   PubMed=20485560; DOI=10.1371/journal.pgen.1000943;
RA   Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D.,
RA   Vangronsveld J., Newman L., Monchy S.;
RT   "Genome sequence of the plant growth promoting endophytic bacterium
RT   Enterobacter sp. 638.";
RL   PLoS Genet. 6:E1000943-E1000943(2010).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; CP000653; ABP61350.1; -; Genomic_DNA.
DR   RefSeq; WP_015959683.1; NC_009436.1.
DR   AlphaFoldDB; A4WCC0; -.
DR   SMR; A4WCC0; -.
DR   STRING; 399742.Ent638_2684; -.
DR   EnsemblBacteria; ABP61350; ABP61350; Ent638_2684.
DR   KEGG; ent:Ent638_2684; -.
DR   eggNOG; COG0845; Bacteria.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   OrthoDB; 1432684at2; -.
DR   Proteomes; UP000000230; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Signal; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           22..411
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_5000238034"
FT   REGION          33..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          389..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   411 AA;  43679 MW;  5A68B6F03E2F1FD5 CRC64;
     MKGSNTSRWA IATGIIVVAL AAAWYWHSHS SSNEATTQQQ RPAGGGRHGM RGGSLAPVQA
     ATAVSKSVPR YLTGLGTVTA ANTVTVRSRV DGQLMAIHFQ EGQQVKAGDL LAEIDPSQFK
     VALAQAQGQL AKDKATLANA RRDLARYQQL VKTNLVSRQE LDTQQSLVSE AQGTIKTDEA
     AVASAQLQLD WSRITAPIDG RVGLKQVDIG NQISSGDTTG IVVITQTHPI DLVFTLPENE
     IATVVQAQKT GQPLAVEAWD RTNKAKLSDG TLLSLDNQID ATTGTIKVKA RFNNQDDALF
     PNQFVNARML VATEENAVVI PTAALQMGNE GNFVWVLNSD NKVSKHLVKP GIQDSQTVVI
     SAGLSAGDRV VTDGIDRLTE GAKVEVVDAH SATTASEKPA SREHAKQGAN S