ID   MDTA_ERWAE              Reviewed;         405 AA.
AC   D4I6V2;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=EAM_2183;
OS   Erwinia amylovora (strain ATCC 49946 / CCPPB 0273 / Ea273 / 27-3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Erwinia.
OX   NCBI_TaxID=716540;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49946 / CCPPB 0273 / Ea273 / 27-3;
RX   PubMed=20118253; DOI=10.1128/jb.00022-10;
RA   Sebaihia M., Bocsanczy A.M., Biehl B.S., Quail M.A., Perna N.T.,
RA   Glasner J.D., DeClerck G.A., Cartinhour S., Schneider D.J., Bentley S.D.,
RA   Parkhill J., Beer S.V.;
RT   "Complete genome sequence of the plant pathogen Erwinia amylovora strain
RT   ATCC 49946.";
RL   J. Bacteriol. 192:2020-2021(2010).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FN666575; CBJ46857.1; -; Genomic_DNA.
DR   RefSeq; WP_004158346.1; NC_013971.1.
DR   AlphaFoldDB; D4I6V2; -.
DR   SMR; D4I6V2; -.
DR   GeneID; 8913342; -.
DR   KEGG; eay:EAM_2183; -.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   BioCyc; EAMY716540:EAM_RS10570-MON; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Signal; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           23..405
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_0000414045"
FT   REGION          35..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   405 AA;  43060 MW;  1F7AF88AFA01B9A3 CRC64;
     MKTPRRFPLI ALTVAAVLTA AALYWWYSHS TASTVQNRQG TEQQRASNSQ GSAKRAGNAP
     PVQAAEALRQ NVPQYLSGLG TVTAANTVTL RSRVDGDLVA LHFNEGQEVA AGQLLAEIDP
     RPYEVALMQA EGQLAKDRAT LTNARRDLAR YEKLAQTQLV SAQELDTQRA RVSETLGTIK
     ADEGSVASAR LNLTYSRVTA PIAGRVGLKQ VDVGNYVSSG DANGIVVIAQ THPIDLVFSL
     PESDIASVLS AQKNGKLPVE AWDRNNKNLL TRGTLLSMDN QIDSTTGTVK LKARFDNQDD
     RLFPNQFVNA RLKIGTLEDA IVIPAAALQM GNESHFVWVI NGDSTVSKKI VASGLQGSGQ
     VVISAGLQAG EKVVTDGIDR LTDGAQTEIV PAQASTPLPA SGASS