ID   MDTA_KLEP7              Reviewed;         412 AA.
AC   A6TBH3;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422};
GN   OrderedLocusNames=KPN78578_24830; ORFNames=KPN_02526;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; CP000647; ABR77944.1; -; Genomic_DNA.
DR   RefSeq; WP_004175207.1; NC_009648.1.
DR   AlphaFoldDB; A6TBH3; -.
DR   SMR; A6TBH3; -.
DR   STRING; 272620.KPN_02526; -.
DR   PRIDE; A6TBH3; -.
DR   EnsemblBacteria; ABR77944; ABR77944; KPN_02526.
DR   KEGG; kpn:KPN_02526; -.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Signal;
KW   Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           22..412
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_0000414046"
FT   REGION          33..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          389..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   412 AA;  43392 MW;  878CBDF7221E8111 CRC64;
     MKGSNIRRWG AALAVVIIAG AAYWFWHDRG TSGSGAPAAG QGPQGPGGAR HGRFGAALAP
     VQAATATEEA VPRYLTGLGT VTAANTVTVR SRVDGQLLSL HFQEGQQVKA GDLLAQIDPS
     QFKVALAQAQ GQLAKDQATL ANARRDLARY QQLVKTNLVS RQELDTQQSL VVESAGTVKA
     DEAAVASAQL QLDWTRITAP IDGRVGLKQV DIGNQISSGD TTGIVVLTQT HPIDVVFTLP
     ESSIATVVQA QKAGKALSVE AWDRTNKQKI SVGELLSLDN QIDATTGTIK LKARFSNLDD
     ALFPNQFVNA RLLVDTQQNA VVIPAAALQM GNEGHFVWVL NDENKVSKHS VTPGIQDSQK
     VVISAGLSAG DRVVTDGIDR LTEGAKVEVV TASSGEQAQP APRQSGKHGA RS