ID   MDTA_PANAA              Reviewed;         410 AA.
AC   F2EYD8;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=PAJ_1808;
OS   Pantoea ananatis (strain AJ13355).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Pantoea.
OX   NCBI_TaxID=932677;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AJ13355;
RX   PubMed=22159605; DOI=10.1007/s00253-011-3713-5;
RA   Hara Y., Kadotani N., Izui H., Katashkina J.I., Kuvaeva T.M.,
RA   Andreeva I.G., Golubeva L.I., Malko D.B., Makeev V.J., Mashko S.V.,
RA   Kozlov Y.I.;
RT   "The complete genome sequence of Pantoea ananatis AJ13355, an organism with
RT   great biotechnological potential.";
RL   Appl. Microbiol. Biotechnol. 93:331-341(2012).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; AP012032; BAK11888.1; -; Genomic_DNA.
DR   RefSeq; WP_013026394.1; NC_017531.2.
DR   AlphaFoldDB; F2EYD8; -.
DR   SMR; F2EYD8; -.
DR   STRING; 932677.PAJ_1808; -.
DR   EnsemblBacteria; BAK11888; BAK11888; PAJ_1808.
DR   KEGG; paj:PAJ_1808; -.
DR   PATRIC; fig|932677.3.peg.2112; -.
DR   eggNOG; COG0845; Bacteria.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   BioCyc; PANA932677:PAJ_RS10015-MON; -.
DR   Proteomes; UP000006690; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Signal; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           22..410
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_0000414047"
FT   REGION          36..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   410 AA;  43979 MW;  FF5588F273C8884E CRC64;
     MNNRYPVMKK GLIVLVVIAV AAGGYYWWKH PAQPSSDGDL SGQSAHGKRG NGAHKPLAPV
     QAASAVTESV PQYLNGLGTV TAANTVTVRS RVDGNLMSIH FTEGQQVKAG QLLAEIDPRP
     YQVALMQAQG QLARDQATLA NARRDLARYQ KLAKTSLVSQ QDLDTQNALV SETLGTIKAD
     EGSVASAQLN LTYSRITSPI DGRVGLKQVD IGNYITSGDT NGLVVITQTH PVDVVFSVAE
     NNISQIMQAQ KSGEPLLVEA WDRSNQHLIT RGKLLSLDNQ IDATTGTIKI KARFDNQDDL
     LFPNQFVNAR LKVNTLQDAV VIPAAALQMG NEGHFVWVIN NEDKVSKKSV TAGLQDSQKV
     VISAGLNAGD RVVTDGLDRL TEGAKVEVVA AQSRATKETR ASLPSKGESE