ID   MDTA_PECAS              Reviewed;         411 AA.
AC   Q6D2B2;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=ECA3184;
OS   Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS   carotovora subsp. atroseptica).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=218491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCRI 1043 / ATCC BAA-672;
RX   PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA   Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA   Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA   Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA   Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA   Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA   Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT   "Genome sequence of the enterobacterial phytopathogen Erwinia carotovora
RT   subsp. atroseptica and characterization of virulence factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; BX950851; CAG76082.1; -; Genomic_DNA.
DR   RefSeq; WP_011094706.1; NC_004547.2.
DR   AlphaFoldDB; Q6D2B2; -.
DR   SMR; Q6D2B2; -.
DR   STRING; 218491.ECA3184; -.
DR   EnsemblBacteria; CAG76082; CAG76082; ECA3184.
DR   GeneID; 57209869; -.
DR   KEGG; eca:ECA3184; -.
DR   PATRIC; fig|218491.5.peg.3225; -.
DR   eggNOG; COG0845; Bacteria.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   OrthoDB; 1432684at2; -.
DR   Proteomes; UP000007966; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Signal;
KW   Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           20..411
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_0000018702"
FT   REGION          31..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   411 AA;  44075 MW;  5D7DC832E2D87DED CRC64;
     MNAKRIRGLL ILAAVIAIAV LIWRHFTQTT PAAPGTSEQH AARTSHSENS GSGGGRRAAM
     RTLAPVQAAL TQSASVPHYL SGLGTVTAAN TVTLRSRVNG QLMALHFQEG QQVKVGDLLA
     EIDPRPFQVE LTQAQGQLAK DQAALLNTRQ DLARYQQLVK TNLISRQELD TQTAAVRQAE
     GALKADEGAV ASAQLQLDYS KITAPISGRI GLKQVDVGNY ITSGDTNGIV VITQTYPIDV
     VFTVPEAEIS TILNAQKSGQ PPVVEAWDRA NQKKLSQGIL LSMDNQIDTT TGTIKLKARF
     DNLDDALFPN QFVNIRMKVD TLKNAVVAPS AAVQMGNDGR FVWILNNKNE VSKRQVTTSI
     QYGQLVVVTA GLDADVQVVT DGIDRLTEGA KVEIVPSALT EKTPAIAGEK S