ID   MDTA_PECCP              Reviewed;         413 AA.
AC   C6DBC6;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=PC1_2966;
OS   Pectobacterium carotovorum subsp. carotovorum (strain PC1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=561230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PC1;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C.,
RA   Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Balakrishnan V., Glasner J., Perna N.T.;
RT   "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; CP001657; ACT13989.1; -; Genomic_DNA.
DR   RefSeq; WP_015841144.1; NC_012917.1.
DR   AlphaFoldDB; C6DBC6; -.
DR   SMR; C6DBC6; -.
DR   STRING; 561230.PC1_2966; -.
DR   EnsemblBacteria; ACT13989; ACT13989; PC1_2966.
DR   KEGG; pct:PC1_2966; -.
DR   eggNOG; COG0845; Bacteria.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   OrthoDB; 1432684at2; -.
DR   Proteomes; UP000002736; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Signal; Transport.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           33..413
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_5000485858"
FT   REGION          32..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..57
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   413 AA;  44198 MW;  0AA2C80B046EF3A3 CRC64;
     MNAKRIRGLL IFAAVIAIAV LIWRHFTQTS PAAPGTSEQH AARTSHSGNN SSGNGGGRRA
     AMRTLAPVQA AVTQSASVPY YLSGLGTVTS ANTVTLRSRV NGQLMALHFQ EGQQVKAGDL
     LAEIDPRPFQ VELTQAQGQL AKDRAVLANA QQDLARYQQL VKTNLISRQE LDAQTAAVRQ
     AEGTLKADEG AVASAQLQLD YSKITAPISG RIGLKQVDVG NYITSGDTNG IVVITQTYPI
     DVVFTVPEAE ISTILNAQKS GQPPMVEAWD RANQKKLSQG TLLSMDNQID ATTGTIKLKA
     RFDNLDDALF PNQFVNIRMK VDTLKNAVVA PSAAVQMGNE GRFVWILNDK NEVSKRQVTT
     SIQYGQLVVV TAGLDADVKV VTDGIDRLTE GAKVEVVPSA LTEKTPAIAG EKS