ID   MDTA_PHOLL              Reviewed;         401 AA.
AC   Q7N3E3;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=plu2774;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; BX571868; CAE15148.1; -; Genomic_DNA.
DR   RefSeq; WP_011146994.1; NC_005126.1.
DR   AlphaFoldDB; Q7N3E3; -.
DR   SMR; Q7N3E3; -.
DR   STRING; 243265.plu2774; -.
DR   EnsemblBacteria; CAE15148; CAE15148; plu2774.
DR   GeneID; 24170416; -.
DR   KEGG; plu:plu2774; -.
DR   eggNOG; COG0845; Bacteria.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   OrthoDB; 1432684at2; -.
DR   BioCyc; PLUM243265:PLU_RS13760-MON; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Signal;
KW   Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           21..401
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_0000018703"
SQ   SEQUENCE   401 AA;  43759 MW;  5F0BFE9E3D39EFB9 CRC64;
     MNQNNKHRTL LFRAALAAIA IAAAIFFWYQ LKTPQQSSPS DQSSGLRHSP LPPVQVATAK
     EQAVPRFLAG LGTIQAANTA TVTSRVEGQL IALHFQEGQQ IKQGDLLAEI DPRPFQVQLA
     QAKGQLAKDE AILANARQDL NRYQKLANTH LISQQEMDNQ RALVRQHEAS LKVDQAAIDS
     AKLQLTYSRI TAPISGKVGL KQIDVGNFIS SGNSSSIVVI TQTDPVDVLF SLPENDINAV
     LQAQKTNHDV VVSAWDRNNQ QQLAAGKLLS IDNQIDATTG TIKLKARFSN QESILFPNQF
     VNVRIKVDTL ENAVVIPNAA LQMGNEGNFV WMLGKENKVS KHLVTVKLQD TKRVVISAGL
     AAGDKVVTDG IDRLTDGAKV DIVTPMVNKP QPQKHDQTEN S