ID   MDTA_PROMH              Reviewed;         411 AA.
AC   B4EY99;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=PMI1585;
OS   Proteus mirabilis (strain HI4320).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=529507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HI4320;
RX   PubMed=18375554; DOI=10.1128/jb.01981-07;
RA   Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S.,
RA   Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T.,
RA   Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA   Rabbinowitsch E., Walker D., Whithead S., Thomson N.R., Rather P.N.,
RA   Parkhill J., Mobley H.L.T.;
RT   "Complete genome sequence of uropathogenic Proteus mirabilis, a master of
RT   both adherence and motility.";
RL   J. Bacteriol. 190:4027-4037(2008).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; AM942759; CAR43317.1; -; Genomic_DNA.
DR   RefSeq; WP_012368040.1; NC_010554.1.
DR   AlphaFoldDB; B4EY99; -.
DR   SMR; B4EY99; -.
DR   STRING; 529507.PMI1585; -.
DR   EnsemblBacteria; CAR43317; CAR43317; PMI1585.
DR   GeneID; 6801611; -.
DR   KEGG; pmr:PMI1585; -.
DR   eggNOG; COG0845; Bacteria.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   Proteomes; UP000008319; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Signal;
KW   Transport.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           27..411
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_0000414048"
FT   REGION          35..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   411 AA;  44324 MW;  881909C1C33A2194 CRC64;
     MNNNKKTKKR FSLIIILLIV IAGAIAYWQY SSNNSAPPVS KDTPTANTPN RSTAGSRRPP
     MPPVQVATSA QEDVPQFLTA LGTVKAVNSV TVTSRVEGQL MALHFTEGQQ VNQGDLLAEI
     DPRPFEVQLA QAKGQLAKDQ ATLANARLDL ARYQKLAKTH LVSQQELDNQ AALVKQSEAS
     ISIDKAAINN AQLQLTYSKI TAPISGRVGL KQVDVGNYIS GGSSTPIVVI NQMDPVDVLF
     TLPEQDLSQV ILARKNNPTL PVIALDRNNK IELAQGALFS VDNQIDATTG TIKLKARFPQ
     QESTLFPNQF VNIRLYVTTL EKAVVIPNAA LQMGNEGHFV WVVDEENKVS KLAVEVASQN
     ADKVVIASGL SANQRVVTDG VDRLTQGAKV EIVTPLAPKA KTTDPVVAEK A