ID   MDTA_SALHS              Reviewed;         413 AA.
AC   B4T9U0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=SeHA_C2356;
OS   Salmonella heidelberg (strain SL476).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=454169;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL476;
RX   PubMed=21602358; DOI=10.1128/jb.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; CP001120; ACF69645.1; -; Genomic_DNA.
DR   RefSeq; WP_000678817.1; NC_011083.1.
DR   AlphaFoldDB; B4T9U0; -.
DR   SMR; B4T9U0; -.
DR   KEGG; seh:SeHA_C2356; -.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   Proteomes; UP000001866; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Repeat; Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           21..413
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_1000145642"
FT   REGION          31..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..413
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   413 AA;  44072 MW;  BE847D7E67A9458C CRC64;
     MKGSNTFRWA IAIGVVVAAA AFWFWHSRSE SPTAAPGVAA QAPHTAAAGR RGMRDGPLAP
     VQAATATTQA VPRYLSGLGT VTAANTVTVR SRVDGQLIAL HFQEGQQVNA GDLLAQIDPS
     QFKVALAQAQ GQLAKDNATL ANARRDLARY QQLAKTNLVS RQELDAQQAL VNETQGTIKA
     DEANVASAQL QLDWSRITAP VSGRVGLKQV DVGNQISSSD TAGIVVITQT HPIDLIFTLP
     ESDIATVVQA QKAGKTLVVE AWDRTNSHKL SEGVLLSLDN QIDPTTGTIK IKARFTNQDD
     TLFPNQFVNA RMLVDTEQNA VVVPAAAVQM GNEGHFVWVL NDENNVSKMR VKIGIQDNQN
     VVISAGLSAG DRVVTDGIDR LTEGAKVEVV EPQTTMADEK SPSRHEGQKG ARA