ID   MDTA_SALPC              Reviewed;         413 AA.
AC   C0Q1F4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=SPC_1592;
OS   Salmonella paratyphi C (strain RKS4594).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=476213;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RKS4594;
RX   PubMed=19229335; DOI=10.1371/journal.pone.0004510;
RA   Liu W.-Q., Feng Y., Wang Y., Zou Q.-H., Chen F., Guo J.-T., Peng Y.-H.,
RA   Jin Y., Li Y.-G., Hu S.-N., Johnston R.N., Liu G.-R., Liu S.-L.;
RT   "Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis
RT   and pathogenic convergence with Salmonella typhi.";
RL   PLoS ONE 4:E4510-E4510(2009).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; CP000857; ACN45740.1; -; Genomic_DNA.
DR   RefSeq; WP_000678815.1; NC_012125.1.
DR   AlphaFoldDB; C0Q1F4; -.
DR   SMR; C0Q1F4; -.
DR   EnsemblBacteria; ACN45740; ACN45740; SPC_1592.
DR   KEGG; sei:SPC_1592; -.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   Proteomes; UP000001599; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Repeat; Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           21..413
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_1000184862"
FT   REGION          31..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          391..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..413
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   413 AA;  44097 MW;  EB22DE7BC20947C7 CRC64;
     MKGSNTFRWA IAIGVVVAAA AFWFWHSRSE SPTAAPGVAA QAPHTAAAGR RGMRDGPLAP
     VQAATATTQA VPRYLSGLGT VTAANTVTVR SRVDGQLIAL HFQEGQQVNA GDLLAQIDPS
     QFKVALAQAQ GQLAKDNATL ANARRDLARY QQLAKTNLVS RQELDAQQAL VNETQGTIKA
     DEANVASAQL QLDWSRITAP VSGRVGLKQV DVGNQISSSD TAGIVVITQT HPIDLIFTLP
     ESDIATVVQA QKAGKTLVVE AWDRTNSHKL SEGVLLSLDN QIDPTTGTIK IKARFTNQDD
     TLFPNQFVNA RMLVDTEQNA VVVPAAAVQM GNEGHFVWVL NDENNVSKKR VKIGIQDNRN
     VVISAGLSAG DRVVTDGIDR LTEGAKVEVV EPQTTMADEK SPSRHEGQKG ARA