ID   MDTA_SALTY              Reviewed;         413 AA.
AC   Q8ZNQ3;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=STM2126;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE006468; AAL21030.1; -; Genomic_DNA.
DR   RefSeq; NP_461071.1; NC_003197.2.
DR   RefSeq; WP_000678822.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZNQ3; -.
DR   SMR; Q8ZNQ3; -.
DR   STRING; 99287.STM2126; -.
DR   PaxDb; Q8ZNQ3; -.
DR   EnsemblBacteria; AAL21030; AAL21030; STM2126.
DR   GeneID; 1253647; -.
DR   KEGG; stm:STM2126; -.
DR   PATRIC; fig|99287.12.peg.2251; -.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   PhylomeDB; Q8ZNQ3; -.
DR   BioCyc; SENT99287:STM2126-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:1990281; C:efflux pump complex; IDA:AgBase.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015562; F:efflux transmembrane transporter activity; IDA:AgBase.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Signal;
KW   Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           21..413
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_0000018705"
FT   REGION          31..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          391..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..413
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   413 AA;  44051 MW;  9EE8A8E981442D8C CRC64;
     MKGSNTFRWA IAIGVVVAAA AFWFWHSRSE SPTAAPGVAA QAPHTASAGR RGMRDGPLAP
     VQAATATTQA VPRYLSGLGT VTAANTVTVR SRVDGQLIAL HFQEGQQVNA GDLLAQIDPS
     QFKVALAQAQ GQLAKDNATL ANARRDLARY QQLAKTNLVS RQELDAQQAL VNETQGTIKA
     DEANVASAQL QLDWSRITAP VSGRVGLKQV DVGNQISSSD TAGIVVITQT HPIDLIFTLP
     ESDIATVVQA QKAGKALVVE AWDRTNSHKL SEGVLLSLDN QIDPTTGTIK IKARFTNQDD
     TLFPNQFVNA RMLVDTEQNA VVVPAAAVQM GNEGHFVWVL NDENNVSKKR VKIGIQDNRN
     VVISAGLSAG DRVVTDGIDR LTEGAKVEVV EPQTTVADEK SPSRHEGQKG ARA