ID   MDTA_SHIFL              Reviewed;         350 AA.
AC   Q83KI5;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Putative multidrug resistance protein MdtA;
DE   AltName: Full=Multidrug transporter MdtA;
GN   Name=mdtA; OrderedLocusNames=SF2139, S2264;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000305}.
CC   -!- CAUTION: This sequence is shorter in the N-terminal part than sequences
CC       from orthologs. It is not possible to make it longer. {ECO:0000305}.
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DR   EMBL; AE005674; AAN43674.1; -; Genomic_DNA.
DR   EMBL; AE014073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_707967.1; NC_004337.2.
DR   AlphaFoldDB; Q83KI5; -.
DR   SMR; Q83KI5; -.
DR   STRING; 198214.SF2139; -.
DR   EnsemblBacteria; AAN43674; AAN43674; SF2139.
DR   GeneID; 1024632; -.
DR   KEGG; sfl:SF2139; -.
DR   PATRIC; fig|198214.7.peg.2553; -.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   OrthoDB; 1432684at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transport.
FT   CHAIN           1..350
FT                   /note="Putative multidrug resistance protein MdtA"
FT                   /id="PRO_0000201882"
FT   REGION          327..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   350 AA;  37682 MW;  93E59FA2FEF2DF14 CRC64;
     MLDNLIGARY LTGLGTITAA NTVTVRSRVD GQLMALHFQE GQQVKAGDLL AEIDPSQFKV
     ALAQTQGQLA KDKATLANAR RDLARYQQLA KTNLVSRQEL DAQQALVSET EGTIKADEAS
     VASAQLQLDW SRITAPVDGR VGLKQVDVGN QISSGDTTGI VVITQTHPID LVFTLPESDI
     ATVVQAQKAG KPLMVEAWDR TNSKKLSEGT LLSLDNQIDA TTGTIKVKAR FNNQDDALFP
     NQFVNARMLV DTEQNAVVIP TAALQMGNEG HFVWVLNSEN KVSKHLVTPG IQDSQKVVIR
     AGISAGDRVV TDGIDRLTEG AKVEVVEAQS ATTPEEKATS REYAKKGARS