ID   MDTA_XENBS              Reviewed;         413 AA.
AC   D3V7P2;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=XBJ1_2730;
OS   Xenorhabdus bovienii (strain SS-2004).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406818;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS-2004;
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C., de Leon L.,
RA   Drace K., Du Z., Givaudan A., Herbert Tran E.E., Jewell K.A., Knack J.J.,
RA   Krasomil-Osterfeld K.C., Kukor R., Lanois A., Latreille P.,
RA   Leimgruber N.K., Lipke C.M., Liu R., Lu X., Martens E.C., Marri P.R.,
RA   Medigue C., Menard M.L., Miller N.M., Morales-Soto N., Norton S.,
RA   Ogier J.C., Orchard S.S., Park D., Park Y., Qurollo B.A., Sugar D.R.,
RA   Richards G.R., Rouy Z., Slominski B., Slominski K., Snyder H., Tjaden B.C.,
RA   van der Hoeven R., Welch R.D., Wheeler C., Xiang B., Barbazuk B.,
RA   Gaudriault S., Goodner B., Slater S.C., Forst S., Goldman B.S.,
RA   Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and photorhabdus:
RT   convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:E27909-E27909(2011).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; FN667741; CBJ81854.1; -; Genomic_DNA.
DR   RefSeq; WP_012989140.1; NC_013892.1.
DR   AlphaFoldDB; D3V7P2; -.
DR   SMR; D3V7P2; -.
DR   STRING; 406818.XBJ1_2730; -.
DR   EnsemblBacteria; CBJ81854; CBJ81854; XBJ1_2730.
DR   GeneID; 8832346; -.
DR   KEGG; xbo:XBJ1_2730; -.
DR   PATRIC; fig|406818.4.peg.2464; -.
DR   eggNOG; COG0845; Bacteria.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   Proteomes; UP000002045; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome; Signal;
KW   Transport.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           26..413
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_0000414049"
FT   REGION          394..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   413 AA;  45402 MW;  D3A9C811501A3C65 CRC64;
     MKNKRRTYFF QFAVLAVVIA TAYFAWNYFK ASTISEEKSA QASKSLQDLK YLLQPPVQVA
     TAKIQSVPHY LGGLGTVQAA NTVTVTSLVA GQLTALHFDE GQFVKQGDLL AEIDPRSFQI
     QLAKVQGQYA KDQATLANSR QDLVRYQQLA KNKSISQQDL DKQISTVRQY EALLKADQSS
     IDDARLQLTY SRITAPISGR VGLKKIDVGN YISAGGGTPL VIITQVDPID VLFALPENDI
     SAVLKAQKNN KDVVVTAWDR NNQQQLAQGK LLSIDNLIDV TTGTIKMKAR FDNQNNVLFP
     NQFVNIQIKV NTLENAIVIP NAALQMSSEG HYVWKVDKEN KVNKRKVTIG LQNAQLVVIS
     KGLATGDRVV TDGTDALTEG TGITIVKPLK SESANTYDQM DKSKPSNSKV ENT