ID   MDTA_YERE8              Reviewed;         443 AA.
AC   A1JKX1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=YE1109;
OS   Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS   8081).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=393305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 13174 / 8081;
RX   PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA   Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA   Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA   Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA   Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA   Prentice M.B.;
RT   "The complete genome sequence and comparative genome analysis of the high
RT   pathogenicity Yersinia enterocolitica strain 8081.";
RL   PLoS Genet. 2:2039-2051(2006).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; AM286415; CAL11205.1; -; Genomic_DNA.
DR   RefSeq; WP_011815802.1; NC_008800.1.
DR   RefSeq; YP_001005439.1; NC_008800.1.
DR   AlphaFoldDB; A1JKX1; -.
DR   SMR; A1JKX1; -.
DR   STRING; 393305.YE1109; -.
DR   EnsemblBacteria; CAL11205; CAL11205; YE1109.
DR   KEGG; yen:YE1109; -.
DR   PATRIC; fig|393305.7.peg.1210; -.
DR   eggNOG; COG0845; Bacteria.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   Proteomes; UP000000642; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Repeat; Signal; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           25..443
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_0000302619"
FT   REGION          36..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        429..443
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   443 AA;  47221 MW;  1B65B14D016AA85A CRC64;
     MKAQSKRTSR LLILLGIAVA IIVAVFVWRH FSATPDGSTG AQQHAVGNNP ARAGGRRNMP
     MPPVQAATAT EQAVPRYLTG LGTVIAANTV TVTSQVDGQL MAIHFTEGQQ VNAGDLLVEI
     DPRPYQVQLT QAQGQLAKDQ ATLDNARRDL ARYQKLAKTG LISQQDLDTQ ASLVRQSEGS
     VKADQGAIDS AKLQLTYSRI TAPISGKVGL KQVDVGNYIT SGTTTPIVVI TQTHPVDVVF
     TLPESDIPAI MQAQKNAAKN NTTVPVEAWD RTNKQMLAQG YLLSIDNQID TTTGTIKLKA
     RFANEDDVLF PNQFVNARIK VDLLQNAVVV PTAAVQMGNE GSFVWTLNDE NKVSKHLVTT
     GIQDSKQVVI SAGLDAGQRV VTDGIDRLTE GLQVEVVTPR SADTTPTDAA EKPATAEKAT
     HRRGEKSATG ASAGSTTTAA EKS