ID   MDTA_YERP3              Reviewed;         444 AA.
AC   A7FG18;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422};
GN   OrderedLocusNames=YpsIP31758_1215;
OS   Yersinia pseudotuberculosis serotype O:1b (strain IP 31758).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=349747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP 31758;
RX   PubMed=17784789; DOI=10.1371/journal.pgen.0030142;
RA   Eppinger M., Rosovitz M.J., Fricke W.F., Rasko D.A., Kokorina G.,
RA   Fayolle C., Lindler L.E., Carniel E., Ravel J.;
RT   "The complete genome sequence of Yersinia pseudotuberculosis IP31758, the
RT   causative agent of Far East scarlet-like fever.";
RL   PLoS Genet. 3:1508-1523(2007).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; CP000720; ABS45971.1; -; Genomic_DNA.
DR   RefSeq; WP_012104821.1; NC_009708.1.
DR   AlphaFoldDB; A7FG18; -.
DR   SMR; A7FG18; -.
DR   EnsemblBacteria; ABS45971; ABS45971; YpsIP31758_1215.
DR   KEGG; ypi:YpsIP31758_1215; -.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   Proteomes; UP000002412; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Repeat; Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           21..444
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_1000068500"
FT   REGION          37..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  47472 MW;  B1C7BDF9112E06B6 CRC64;
     MKSQSKRTSR LFVFVGGVVA IIIAVLSWRY FGTGSDNNTS GAQQSARGQD TSHGGRRNTP
     LAPVQAATAT EQEVPRYLTG LGTVIAANTV TVTSRVDGEL MALHFTEGQQ VKAGDLLAEI
     DPRPYEVQLT QAQGQLAKDQ ATLDNARRDL ARYQKLSKTG LISQQELDTQ SSLVRQSEGS
     VKADQGAIDS AKLQLTYSRI TAPISGRVGL KQVDVGNYIT SGTATPIVVI TQTHPVDVVF
     TLPESDIPAI IQAQKNAEKT HAIVPVEAWD RTNKQMLAQG YLLSIDNQID TTTGTIKLKA
     RFNNEDDVLF PNQFVNARIK VDLLQNAVVV PTAAVQMGSE GNFVWTLDDA NKVSKHLVTT
     GIQNSQQVVI DAGLNAGQRV VTDGIDRLTE GVQVEVVTPR SANTDANPAS AEKAAAEAEG
     STPHQGRGRP ANAPARSTTA AEKS