ID   MDTA_YERPB              Reviewed;         444 AA.
AC   B2K9L9;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=YPTS_2919;
OS   Yersinia pseudotuberculosis serotype IB (strain PB1/+).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=502801;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB1/+;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C.,
RA   Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.;
RT   "Complete sequence of Yersinia pseudotuberculosis PB1/+.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; CP001048; ACC89876.1; -; Genomic_DNA.
DR   RefSeq; WP_011192781.1; NZ_CP009780.1.
DR   AlphaFoldDB; B2K9L9; -.
DR   SMR; B2K9L9; -.
DR   GeneID; 66844764; -.
DR   KEGG; ypb:YPTS_2919; -.
DR   PATRIC; fig|502801.10.peg.2348; -.
DR   OMA; GQLMAIH; -.
DR   BioCyc; YPSE502801:YPTS_RS14700-MON; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Repeat; Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           21..444
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_1000145645"
FT   REGION          37..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          399..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  47591 MW;  C3303C0F56C60AE6 CRC64;
     MKSQSKRTSR LFVFVGVVVA IIIAVLSWRY FGTGSDNNTS GAQQSARGQD TSHGGRRNTP
     LAPVQAATAT EQEVPRYLTG LGTVIAANTV TVTSRVDGEL MALHFTEGQQ VKAGDLLAEI
     DPRPYEVQLT QAQGQLAKDQ ATLDNARRDL ARYQKLSKTG LISQQELDTQ SSLVRQSEGS
     VKADQGAIDS AKLQLTYSRI TAPISGRVGL KQVDVGNYIT SGTATPIVVI TQTHPVDVVF
     TLPESDIPAI MQAQKNAEKT HAIVPVEAWD RTNKQMLAQG YLLSIDNQID TTTGTIKLKA
     RFNNEDDVLF PNQFVNARIK VDLLQNAVVV PTAAVQMGSE GNFVWTLDDA NRVSKHLVTT
     GIQDSQQVVI DAGLNAGQRV VTDGIDRLTE GVQVEVVTPR SANTDTNPAS AEKAAAEAEG
     STPHQGRGRP ANAPARSTTA AEKS